bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 27, 2024
Neonatal
pain
is
a
significant
clinical
issue
but
the
mechanisms
by
which
produced
early
in
life
are
poorly
understood.
Our
recent
work
has
linked
transcription
factor
serum
response
downstream
of
local
growth
hormone
(GH)
signaling
to
incision-related
hypersensitivity
neonates.
However,
it
remains
unclear
if
similar
contribute
inflammatory
We
found
that
GH
treatment
inhibited
neonatal
myalgia
appeared
do
so
through
unique
signal
transducer
and
activator
(STAT)
dependent
pathway
within
sensory
neurons.
The
STAT1
regulate
peripheral
inflammation
itself
modulation
monocyte
chemoattractant
protein
1
(MCP1)
release
from
Data
suggests
upregulation,
signaling,
contributes
nociception
during
muscle
novel
neuroimmune
loop
involving
cytokine
primary
afferents.
Results
could
uncover
new
ways
treat
Cell,
Journal Year:
2024,
Volume and Issue:
187(15), P. 4043 - 4060.e30
Published: June 14, 2024
Inflammation-induced
neurodegeneration
is
a
defining
feature
of
multiple
sclerosis
(MS),
yet
the
underlying
mechanisms
remain
unclear.
By
dissecting
neuronal
inflammatory
stress
response,
we
discovered
that
neurons
in
MS
and
its
mouse
model
induce
stimulator
interferon
genes
(STING).
However,
activation
STING
requires
detachment
from
stromal
interaction
molecule
1
(STIM1),
process
triggered
by
glutamate
excitotoxicity.
This
initiates
non-canonical
signaling,
which
leads
to
autophagic
degradation
glutathione
peroxidase
4
(GPX4),
essential
for
redox
homeostasis
thereby
inducing
ferroptosis.
Both
genetic
pharmacological
interventions
target
protect
against
inflammation-induced
neurodegeneration.
Our
findings
position
as
central
regulator
detrimental
integrating
inflammation
with
signaling
cause
cell
death,
present
it
tractable
treating
MS.
PLoS Pathogens,
Journal Year:
2024,
Volume and Issue:
20(5), P. e1011820 - e1011820
Published: May 8, 2024
The
production
of
IFN-γ
is
crucial
for
control
multiple
enteric
infections,
but
its
impact
on
intestinal
epithelial
cells
(IEC)
not
well
understood.
Cryptosporidium
parasites
exclusively
infect
and
the
ability
interferons
to
activate
transcription
factor
STAT1
in
IEC
required
parasite
clearance.
Here,
use
single
cell
RNA
sequencing
profile
during
infection
revealed
an
increased
proportion
mid-villus
enterocytes
induction
IFN-γ-dependent
gene
signatures
that
was
comparable
between
uninfected
infected
cells.
These
analyses
were
complemented
by
vivo
studies,
which
demonstrated
expression
receptor
control.
Unexpectedly,
treatment
Ifng
-/-
mice
with
showed
response
this
cytokine
correlates
a
delayed
reduction
burden
did
affect
development.
data
sets
provide
insight
into
suggest
model
signalling
important
.
Brain Behavior and Immunity,
Journal Year:
2023,
Volume and Issue:
115, P. 458 - 469
Published: Nov. 3, 2023
The
gut
microbiome
consists
of
trillions
bacteria,
fungi,
and
viruses
that
inhabit
the
digestive
tract.
These
communities
are
sensitive
to
disruption
from
environmental
exposures
ranging
diet
changes
illness.
Disruption
community
lactic
acid
producing
Lactobaccillacea,
has
been
well
documented
in
mood
disorders
stress
exposure.
In
fact,
oral
supplement
with
many
Lactobacillus
species
can
ameliorate
these
effects,
preventing
depression-
anxiety-like
behavior.
Here,
we
utilize
a
gnotobiotic
mouse
colonized
Altered
Schaedler
Flora
remove
two
native
Lactobaccillacea:
L.
intestinalis
murinus.
Using
this
microbial
community,
found
themselves,
not
disrupted
protective
stressors.
Further,
determine
Lactobaccillacea
maintaining
homeostatic
IFNγ
levels
which
mediating
behavioral
circuit
level
responses.
By
utilizing
Flora,
have
gained
new
insight
into
how
probiotics
influence
behavior
provide
novel
methods
study
potential
therapies
treat
disorders.
Frontiers in Psychiatry,
Journal Year:
2024,
Volume and Issue:
15
Published: April 25, 2024
Autism
spectrum
disorder
(ASD)
is
a
neurodevelopmental
that
encompasses
range
of
symptoms
including
difficulties
in
verbal
communication,
social
interaction,
limited
interests,
and
repetitive
behaviors.
Neuroplasticity
refers
to
the
structural
functional
changes
occur
nervous
system
adapt
respond
external
environment.
In
simpler
terms,
it
brain's
ability
learn
new
environments.
However,
individuals
with
ASD
exhibit
abnormal
neuroplasticity,
which
impacts
information
processing,
sensory
cognition,
leading
manifestation
corresponding
symptoms.
This
paper
aims
review
current
research
progress
on
focusing
genetics,
environment,
neural
pathways,
neuroinflammation,
immunity.
The
findings
will
provide
theoretical
foundation
insights
for
intervention
treatment
pediatric
fields
related
ASD.
Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: June 10, 2024
Neuropathic
pain
(NP)
is
characterized
by
its
complex
and
multifactorial
nature
limited
responses
to
opioid
therapy;
NP
associated
with
risks
of
drug
resistance,
addiction,
difficulty
in
treatment
cessation,
psychological
disorders.
Emerging
research
on
gut
microbiota
their
metabolites
has
demonstrated
effectiveness
alleviating
augmenting
opioid-based
management,
concurrently
mitigating
the
adverse
effects
opioids.
This
review
addresses
following
key
points:
(1)
current
advances
challenges
using
opioids
treat
NP,
(2)
reciprocal
benefits
(3)
interaction
between
microbiota,
as
well
NP.
Through
various
intricate
mechanisms,
influences
onset
progression
ultimately
enhancing
efficacy
management
These
insights
pave
way
for
further
pragmatic
clinical
research,
management.
