The Use of SGLT-2 Inhibitors and GLP-1RA in Frail Older People with Diabetes: A Personalised Approach Is Required
Metabolites,
Год журнала:
2025,
Номер
15(1), С. 49 - 49
Опубликована: Янв. 14, 2025
Background:
Frailty
is
an
increasingly
recognised
complication
of
diabetes
in
older
people
and
should
be
taken
into
consideration
management
plans,
including
the
use
new
therapies
sodium
glucose
cotransporter-2
(SGLT-2)
inhibitors
glucagon
like
peptide-1
receptor
agonists
(GLP-1RA).
The
frailty
syndrome
appears
to
span
across
a
spectrum,
from
sarcopenic
obese
phenotype
at
one
end,
characterised
by
obesity,
insulin
resistance,
prevalent
cardiovascular
risk
factors,
anorexic
malnourished
other
significant
weight
loss,
reduced
less
factors.
Therefore,
may
not
suitable
for
every
frail
individual
with
diabetes.
Objectives:
To
review
characteristics
who
benefit
SGLT-2
or
GLP-1RA.
Methods:
A
narrative
studies
investigating
benefits
GLP-1RA
Results:
current
evidence
indirect,
literature
suggests
that
are
effective
proportional
severity
frailty.
However,
patients
described
benefited
such
therapy
appeared
either
overweight
obese,
have
higher
prevalence
unfavourable
metabolism
factors
as
dyslipidaemia,
gout,
hypertension
compared
non-frail
subjects.
They
also
established
disease
individuals.
In
absolute
terms,
their
baseline
meant
they
most
therapy.
this
group
fulfil
criteria
phenotype,
which
likely
due
metabolic
profile
phenotype.
There
no
suggest
underrepresented
totally
excluded
these
studies,
living
care
homes.
This
intolerant
its
associated
inducing
further
dehydration,
hypotension.
Conclusions:
Clinicians
consider
early
normal
weight,
overweight,
avoid
those
subjects
ae
underweight,
anorexic,
malnourished.
Язык: Английский
Association of iodized salt intake with the risk of physical frailty in patients with type 2 diabetes
The journal of nutrition health & aging,
Год журнала:
2025,
Номер
29(6), С. 100543 - 100543
Опубликована: Март 26, 2025
Язык: Английский
Letter to the editor on: “Joint effects of physical frailty and traditional cardiovascular risk factor control on cardiovascular disease in patients with diabetes”
The journal of nutrition health & aging,
Год журнала:
2024,
Номер
28(10), С. 100360 - 100360
Опубликована: Сен. 7, 2024
Язык: Английский