The Use of SGLT-2 Inhibitors and GLP-1RA in Frail Older People with Diabetes: A Personalised Approach Is Required

Metabolites, Journal Year: 2025, Volume and Issue: 15(1), P. 49 - 49

Published: Jan. 14, 2025

Background: Frailty is an increasingly recognised complication of diabetes in older people and should be taken into consideration management plans, including the use new therapies sodium glucose cotransporter-2 (SGLT-2) inhibitors glucagon like peptide-1 receptor agonists (GLP-1RA). The frailty syndrome appears to span across a spectrum, from sarcopenic obese phenotype at one end, characterised by obesity, insulin resistance, prevalent cardiovascular risk factors, anorexic malnourished other significant weight loss, reduced less factors. Therefore, may not suitable for every frail individual with diabetes. Objectives: To review characteristics who benefit SGLT-2 or GLP-1RA. Methods: A narrative studies investigating benefits GLP-1RA Results: current evidence indirect, literature suggests that are effective proportional severity frailty. However, patients described benefited such therapy appeared either overweight obese, have higher prevalence unfavourable metabolism factors as dyslipidaemia, gout, hypertension compared non-frail subjects. They also established disease individuals. In absolute terms, their baseline meant they most therapy. this group fulfil criteria phenotype, which likely due metabolic profile phenotype. There no suggest underrepresented totally excluded these studies, living care homes. This intolerant its associated inducing further dehydration, hypotension. Conclusions: Clinicians consider early normal weight, overweight, avoid those subjects ae underweight, anorexic, malnourished.

Language: Английский

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Association of iodized salt intake with the risk of physical frailty in patients with type 2 diabetes

The journal of nutrition health & aging, Journal Year: 2025, Volume and Issue: 29(6), P. 100543 - 100543

Published: March 26, 2025

Language: Английский

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Letter to the editor on: “Joint effects of physical frailty and traditional cardiovascular risk factor control on cardiovascular disease in patients with diabetes”

The journal of nutrition health & aging, Journal Year: 2024, Volume and Issue: 28(10), P. 100360 - 100360

Published: Sept. 7, 2024

Language: Английский

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