Phytoestrogens as Potential Anti-Osteoporosis Nutraceuticals: Major Sources and Mechanism(s) of Action

The Journal of Steroid Biochemistry and Molecular Biology, Год журнала: 2025, Номер unknown, С. 106740 - 106740

Опубликована: Март 1, 2025

Язык: Английский

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Qixian granule inhibits ferroptosis in vascular endothelial cells by modulating TRPML1 in the lysosome to prevent postmenopausal atherosclerosis

Journal of Ethnopharmacology, Год журнала: 2024, Номер 328, С. 118076 - 118076

Опубликована: Март 22, 2024

Язык: Английский

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Polymethoxylated flavonoids in citrus fruits: absorption, metabolism, and anticancer mechanisms against breast cancer

PeerJ, Год журнала: 2024, Номер 11, С. e16711 - e16711

Опубликована: Янв. 3, 2024

Polymethoxylated flavonoids (PMFs) are a subclass of found in citrus fruits that have shown multifunctional biological activities and potential anticancer effects against breast cancer. We studied the absorption, metabolism, species source, toxicity, anti-cancer mechanisms, molecular targets PMFs to better utilize their activity discuss absorption metabolism body, including methylation, demethylation, hydroxylation processes. The mechanisms cancer were also reviewed, estrogen activity, cytochrome P-450 enzyme system, arylhydrocarbon receptor (AhR) inhibition, along with various effects. Although may be advantageous prevention treatment for cancer, there is lack clinical evidence data support efficacy. Despite promise, still long way go before can applied clinically.

Язык: Английский

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Microbial Metabolism of the Soy Isoflavones Daidzein and Genistein in Postmenopausal Women: Human Intervention Study Reveals New Metabotypes

Nutrients, Год журнала: 2023, Номер 15(10), С. 2352 - 2352

Опубликована: Май 17, 2023

Background: Soy isoflavones belong to the group of phytoestrogens and are associated with beneficial health effects but also discussed have adverse effects. Isoflavones intensively metabolized by gut microbiota leading metabolites altered estrogenic potency. The population is classified into different isoflavone metabotypes based on individual metabolite profiles. So far, this classification was capacity metabolize daidzein did not reflect genistein metabolism. We investigated microbial profile considering genistein. Methods: were quantified in urine postmenopausal women receiving a soy extract for 12 weeks. Based these data, clustered metabotypes. Further, potency estimated. Results: excreted urinary amounts metabolites, profiles could be calculated, resulting 5 applying hierarchical cluster analysis. differed part strongly regarding their estimated

Язык: Английский

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Bioisosteric heterocyclic analogues of natural bioactive flavonoids by scaffold-hopping approaches: State-of-the-art and perspectives in medicinal chemistry

Bioorganic & Medicinal Chemistry, Год журнала: 2024, Номер 109, С. 117791 - 117791

Опубликована: Июнь 9, 2024

The flavonoid family is a set of well-known bioactive natural molecules, with wide range potential therapeutic applications. Despite the promising results obtained in preliminary vitro/vivo studies, their pharmacokinetic and pharmacodynamic profiles are severely compromised by chemical instability. To address this issue, scaffold-hopping approach strategy for structural optimization leads to discover more potent analogues. In scenario, Perspective provides critical analysis on how replacement chromon-4-one core other bioisosteric nitrogen/sulphur heterocycles might affect chemical, pharmaceutical biological properties resulting new entities. investigated derivatives were classified basis activity indications. For each session, target(s), specific mechanism action, if available, key pharmacophoric moieties highlighted, as revealed X-ray crystal structures silico structure-based studies. Biological data, examined: particular focus was given improvements observed heterocyclic analogues compared flavonoids. This overview advantages compounds great interest medicinal chemistry community better exploit vast these molecules identify molecules.

Язык: Английский

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Dietary flavonoid intake is associated with a lower risk of depressive symptoms in US adults: Data from NHANES 2007–2008, 2009–2010, and 2017–2018

Journal of Affective Disorders, Год журнала: 2023, Номер 345, С. 293 - 299

Опубликована: Окт. 27, 2023

Depressive symptoms is an important public health problem. The aim of the present study to examine association dietary flavonoid intake with risk depressive symptoms.In this study, we conducted assessment investigate potential between and symptoms. Our analysis was based on a nationally representative sample 9674 adults who participated in 2007-2010 2017-2018 National Health Nutrition Examination Surveys. Flavonoid measured using 24-hour recall method, while evaluated Patient Questionnaire-9. To relationship symptoms, employed logistic regression, subgroup restricted cubic spline models.Following multivariate adjustment, found negative total flavonoids, anthocyanidins, flavanones, flavones, isoflavones In analysis, inversely associated among women whereas no man. Additionally, non-linear observed statistical significance (P for nonlinearity <0.001).The cross-sectional design, which precludes establishment causality. Furthermore, data relied self-reported measures.In moderate flavonoids intake, but not high lower odds suggesting U-shaped association.

Язык: Английский

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Insight into the Potential Mechanisms of Endocrine Disruption by Dietary Phytoestrogens in the Context of the Etiopathogenesis of Endometriosis

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(15), С. 12195 - 12195

Опубликована: Июль 30, 2023

Phytoestrogens (PEs) are estrogen-like nonsteroidal compounds derived from plants (e.g., nuts, seeds, fruits, and vegetables) fungi that structurally similar to 17β-estradiol. PEs bind all types of estrogen receptors, including ERα ERβ nuclear a membrane-bound receptor known as the G protein-coupled (GPER). As endocrine-disrupting chemicals (EDCs) with pro- or antiestrogenic properties, can potentially disrupt hormonal regulation homeostasis, resulting in developmental reproductive abnormalities. However, lack diet does not result development deficiency symptoms. To properly assess benefits risks associated use PE-rich diet, it is necessary distinguish between endocrine disruption (endocrine-mediated adverse effects) nonspecific effects on system. Endometriosis an estrogen-dependent disease unknown etiopathogenesis, which tissue lining uterus (the endometrium) grows outside subsequent complications being manifested local inflammatory reactions. affects 10–15% women age chronic pelvic pain, dysmenorrhea, dyspareunia, infertility. In this review, endocrine-disruptive actions reviewed context endometriosis determine whether has positive negative effect risk course endometriosis.

Язык: Английский

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Alpinumisoflavone Activates Disruption of Calcium Homeostasis, Mitochondria and Autophagosome to Suppress Development of Endometriosis

Antioxidants, Год журнала: 2023, Номер 12(7), С. 1324 - 1324

Опубликована: Июнь 22, 2023

Alpinumisoflavone is an isoflavonoid extracted from the Cudrania tricuspidate fruit and Genista pichisermolliana. It has various physiological functions, such as anti-inflammation, anti-proliferation, apoptosis, in malignant tumors. However, effect of alpinumisoflavone still not known chronic diseases other benign reproductive diseases, endometriosis. In this study, we examined cell death effects on endometriosis lines, End1/E6E7 VK2/E6E7. Results indicated that inhibited migration proliferation led to cycle arrest, depolarization mitochondria membrane potential, disruption calcium homeostasis lines. cellular normal uterine epithelial cells was changed by alpinumisoflavone. The alteration Ca2+ levels estimated fluo-4 AM-stained VK2/E6E7 after treatment with or without inhibitor, 2-aminoethoxydiphenyl borate (2-APB). results a combination inhibitor reduced accumulation cytosol cells. Additionally, decreased oxidative phosphorylation (OXPHOS) endometriotic Moreover, protein expression analysis revealed inactivated AKT signaling pathways, whereas it increased MAPK, ER stress, autophagy regulatory proteins summary, our suggested could be promising effective management agent adjuvant therapy for disease

Язык: Английский

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Bavachin Rejuvenates Sensitivity of Colistin against Colistin-Resistant Gram-Negative Bacteria

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 2349 - 2349

Опубликована: Фев. 16, 2024

The emergence of plasmid-mediated colistin resistance threatens the efficacy as a last-resort antibiotic used to treat infection caused by Gram-negative bacteria (GNB). Given shortage new antibiotics, discovery adjuvants existing antibiotics is promising strategy combat infections multidrug-resistant (MDR) GNB. This study was designed investigate potential synergistic antibacterial activity bavachin, bioactive compound extracted from Psoralea Fructus, combined with against MDR Herein, in vitro and therapeutic bavachin vivo were evaluated. mechanism detected fluorescent probe transcript levels mcr-1. Bavachin showed an excellent GNB, FICI ≤ 0.5. In contrast alone, combination therapy dramatically increased survival rate Galleria mellonella mice vivo. Moreover, significantly reduced amount bacterial biofilm formation, improved membrane disruption inhibited mcr-1 transcription. These findings show that adjuvant colistin, which may provide colistin-resistant lower doses colistin.

Язык: Английский

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Antidepressant- and Anxiolytic-like Effects of Pomegranate: Is It Acting by Common or Well-Known Mechanisms of Action?

Plants, Год журнала: 2024, Номер 13(16), С. 2205 - 2205

Опубликована: Авг. 9, 2024

The pharmacological effects of pomegranates have been described considering metabolic aspects such as hypoglycemic and hypolipidemic activities. pomegranate extract has activity on the central nervous system (CNS) a natural antidepressant anxiolytic. chemical composition is complex since bioactive compounds are multiple secondary metabolites that identified in extracts derived from peel, seed, flowers, leaves, or their combination; so, it not easy to identify an individual compound responsible for its observed properties. From this point view, present review analyzes crude fractions possible mechanisms action concerning antidepressant- anxiolytic-like animal models. Serotonin receptors, estrogen peroxisome proliferator-activated receptor gamma (PPARγ), monoamine oxidase enzymes, well potent antioxidant neuroplasticity properties, mediators involved behaviors after treatment. CNS experimental models associated with specific stress level suggest could simultaneously modulate response by activating several targets. For review, scientific evidence was gathered integrate pathway be pomegranate's effects. Furthermore, potential benefits discussed comorbid conditions anxiety depression, perimenopause transition pain.

Язык: Английский

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