Exploring
innovations
in
geriatric
oncology,
this
article
focuses
on
recent
developments
palliative
care
for
elderly
cancer
patients.It
highlights
the
importance
of
personalized
approaches
and
integration
innovative
practices
such
as
telemedicine
complementary
therapies,
aimed
at
improving
patients'
quality
life.Current
challenges,
including
equitable
access
effective
implementation
care,
are
discussed,
concluding
with
need
ongoing
adaptation
enhancement
oncology.
Nutrients,
Год журнала:
2023,
Номер
15(17), С. 3821 - 3821
Опубликована: Авг. 31, 2023
Lycopene
is
a
compound
of
colored
origin
that
shows
strong
antioxidant
activity.
The
positive
effect
lycopene
the
result
its
pleiotropic
effect.
ability
to
neutralize
free
radicals
via
one
foundations
pro-health
effect,
including
inhibit
development
many
civilization
diseases.
Therefore,
this
study
focuses
on
importance
in
inhibiting
diseases
such
as
cardiovascular
diseases,
within
nervous
system,
diabetes,
liver
and
ulcerative
colitis.
According
research
mentioned,
supplementation
has
significant
promise
for
treatment
illnesses
marked
by
chronic
inflammation
oxidative
stress.
However,
majority
supporting
data
lycopene′s
health
benefits
comes
from
experimental
research,
whereas
evidence
clinical
studies
both
scarcer
less
certain
any
benefits.
Research
humans
still
required
establish
effectiveness.
Frontiers in Veterinary Science,
Год журнала:
2024,
Номер
11
Опубликована: Март 18, 2024
Lycopene
is
a
kind
of
natural
carotenoid
that
could
achieve
antioxidant,
anti-cancer,
lipid-lowering
and
immune-improving
effects
by
up-regulating
or
down-regulating
genes
related
to
immunity.
Furthermore,
lycopene
natural,
pollution-free,
has
no
toxic
side
effects.
The
application
in
animal
production
shown
it
improve
livestock
performance,
slaughter
immunity,
antioxidant
capacity,
intestinal
health,
meat
quality.
Therefore,
as
new
type
feed
additive,
broader
prospects
many
antibiotic-forbidden
environments.
This
article
serves
reference
for
the
use
health
additive
going
over
its
physical
chemical
characteristics,
lipid-lowering,
production.
Environmental Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 14, 2025
Air
pollution
is
a
leading
contributor
to
the
global
disease
burden.
However,
complex
nature
of
chemicals
which
humans
are
exposed
through
inhalation
has
obscured
identification
key
compounds
responsible
for
diseases.
Here,
we
develop
network
topology-based
framework
identify
toxic
in
airborne
chemical
exposome.
Using
cardiovascular
diseases
(CVDs)
as
model
disease,
found
that
modules
various
closely
linked
CVDs.
The
proximity
compound
target
can
indicate
extent
toxicity
induced
by
compounds.
By
integrating
mass
spectrometry-based
external
exposure
concentrations
and
machine
learning-predicted
internal
concentrations,
established
comprehensive
linkage
connecting
disease-related
risk
These
findings
were
subsequently
validated
using
data
on
regional
scale.
This
work
provides
an
effective
strategy
identifying
within
environmental
exposomes
establishes
new
paradigm
understanding
pathogenicity
air
pollution.
Phytotherapy Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 24, 2025
ABSTRACT
The
human
body
gets
exposed
to
a
variety
of
toxins
intentionally
or
unintentionally
on
regular
basis
from
sources
such
as
air,
water,
food,
and
soil.
Certain
can
be
synthetic,
while
some
are
biological.
affect
the
various
parts
by
activating
numerous
pro‐inflammatory
markers,
like
oxidative
stresses,
that
tend
disturb
normal
function
organs
ultimately.
Nowadays,
people
use
different
types
herbal
treatments,
viz.,
drinks
contain
spices
for
detoxification
their
bodies.
One
example
is
turmeric,
most
commonly
available
spice
in
kitchen
used
across
all
kinds
households.
Turmeric
contains
curcumin,
which
natural
polyphenol.
Curcumin
medicinal
compound
with
biological
activities,
antioxidant,
antineoplastic,
anti‐inflammatory,
antibacterial.
Hence,
this
review
gives
comprehensive
insight
into
promising
potential
curcumin
heavy
metals,
carbon
tetrachloride,
drugs,
alcohol,
acrylamide,
mycotoxins,
nicotine,
plastics.
encompasses
diverse
animal‐based
studies
portraying
curcumin's
role
nullifying
toxic
effects
(especially
liver,
kidney,
testicles,
brain)
enhancing
defensive
signaling
pathways,
improving
antioxidant
enzyme
levels,
inhibiting
markers
activities
so
on.
Furthermore,
also
argues
over
safety
assessment
its
utilization
detoxifying
agent.
Journal of Agricultural and Food Chemistry,
Год журнала:
2023,
Номер
71(44), С. 16727 - 16738
Опубликована: Окт. 23, 2023
Di-(2-ethylhexyl)
phthalate
(DEHP)
is
frequently
used
as
a
plasticizer
in
industrial
and
agricultural
products.
DEHP
can
cause
severe
neurotoxicity,
such
impaired
learning
memory
function.
Lycopene
(LYC)
carotenoid
exerts
excellent
antioxidant
capacity
therapeutic
effects
neurodegenerative
diseases.
However,
whether
LYC
prevent
the
cognitive
impairment
induced
by
specific
mechanisms
are
unclear.
In
present
study,
behavioral
test
results
suggested
that
alleviated
DEHP.
The
histopathological
data
revealed
attenuated
DEHP-induced
disordered
arrangement
of
neurons
CA1
CA3
regions
hippocampus
tissue.
Moreover,
inhibited
occurrence
ferroptosis
via
regulating
iron
metabolism,
inhibiting
lipid
peroxidation,
activating
cysteine
transporter
nuclear
factor
erythroid
2-related
2/heme
oxygenase-1
(NrF2/HO-1)
signaling
pathway.
Overall,
study
contributes
novel
perspectives
into
potential
preventing
phthalate-induced
hippocampus.
Lycopene
is
a
compound
of
colored
origin
that
shows
strong
antioxidant
activity.
The
ability
to
neutralize
free
radicals
by
lycopene
the
basis
its
pro-health
effect,
including
inhibit
development
many
civilization
diseases.
Therefore,
this
study
focuses
on
importance
effect
in
inhibiting
such
diseases
as
cardiovascular
diseases,
etiology
etiology,
within
nervous
system.
Antioxidants,
Год журнала:
2023,
Номер
12(11), С. 1958 - 1958
Опубликована: Ноя. 2, 2023
The
intestinal
tract
is
a
target
organ
for
Deoxynivalenol
(DON)
absorption
and
toxicity.
Mitochondrial
homeostasis
imbalance
the
gut
toxicity
mechanism
of
DON.
Lycopene
(LYC)
has
protective
effects
can
maintain
mitochondrial
in
response
to
various
danger
signals.
purpose
this
study
was
explore
effect
LYC
on
DON-induced
IPEC-J2
cells
damage.
These
results
showed
that
DON
exposure
induced
an
increase
levels
malondialdehyde
reactive
oxygen
species
(ROS)
cells.
impaired
cell
barrier
function
caused
dysfunction
by
inducing
permeability
transition
pore
(MPTP)
opening,
membrane
potential
(MMP)
reducing,
destroying
fission
factors,
fusion
mitophagy
factors
expression.
However,
adding
reduce
toxic
decrease
cellular
oxidative
stress,
functional
damage,
dynamics
imbalance,
processes.
In
conclusion,
maintains
counteract
cells'
Journal of Agricultural and Food Chemistry,
Год журнала:
2023,
Номер
71(50), С. 20034 - 20046
Опубликована: Дек. 6, 2023
Lycopene
(LYC)
exerts
a
strong
neuroprotective
and
antipyroptotic
effects.
This
study
explored
the
effects
mechanisms
of
LYC
on
chronic
stress-induced
hippocampal
microglial
damage
depression-like
behaviors.
The
caspase-1
inhibitor
VX-765
attenuated
restrain
stress
(CRS)-induced
pyroptosis
Moreover,
alleviation
CRS-induced
behaviors
by
was
associated
with
cathepsin
B/NLRP3
pathway.
In
vitro,
Z-YVAD-FMK
alleviated
in
highly
aggressively
proliferating
immortalized
(HAPI)
cells.
Additionally,
corticosterone-induced
HAPI
cell
Furthermore,
B
agonist
pazopanib
promoted
pyroptosis,
whereas
inhibited
pazopanib-induced
via
Similarly,
pyroptosis.
These
results
suggest
that
alleviates
pathway
inhibition.
provides
new
strategy
for
treating
encephalopathy.
