Journal of Dairy Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 1, 2024
Donkey
milk,
rich
in
essential
nutrients,
not
only
can
meet
the
nutritional
needs
of
patients
with
chronic
kidney
disease
(CKD)
accodding
to
National
Kidney
Foundation's
Disease
Outcomes
Quality
Initiative
(KDOQI)
Clinical
Practice
Guideline
for
Nutrition
CKD,
but
also
has
strong
anti-inflammatory
ability.
Inflammation
is
main
driving
force
renal
fibrosis,
directly
determining
function
CKD.
However,
impact
donkey
milk
on
CKD
and
underlying
mechanism
remains
unclear.
We
hypothesized
that
supplementation
could
enhance
ability
thereby
inhibiting
fibrosis
improving
function.
So,
we
investigated
influences
a
6-week
treatment
unilateral
ureteral
ligation
(UUO)
induced
rats.
The
results
demonstrated
level
miR-223-3p
was
decreased
kidneys
rats
compared
normal
activated
miR-223-3p,
expression
inhibitor
kappa
B
kinase
(IKKα)
nuclear
factor
kappa-B
(NF-κB)
protein.
Consequently,
inflammatory
factors
such
as
monocyte
chemotactic
protein-1
(MCP-1)
interleukin-6
(IL-6)
were
suppressed,
leading
reduced
aggregations
macrophages
transforming
growth
β1
(TGF-β1)
expression.
Ultimately,
inhibited,
which
confirmed
by
Collagen
type
I
α
1(Col1-a1)
mRNA,
improved.
These
indicate
may
be
another
potential
therapeutic
target
Moreover,
contribution
alleviating
response
obvious,
indicating
new
functional
food
promote
health.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2024,
Номер
14
Опубликована: Апрель 25, 2024
The
Nuclear
factor
erythroid
2-related
2
(Nrf2)/heme
oxygenase-1
(HO-1)
signaling
pathway
has
been
extensively
studied
for
its
role
in
regulating
antioxidant
and
antiviral
responses.
Equid
herpesvirus
type
8
(EqHV-8)
poses
a
significant
threat
to
the
equine
industry,
primarily
manifesting
as
respiratory
disease,
abortions,
neurological
disorders
horses
donkeys.
Oxidative
stress
is
considered
key
associated
with
pathogenesis
of
EqHV-8
infection.
Unfortunately,
there
currently
dearth
therapeutic
interventions
available
effective
control
EqHV-8.
Rutin
well
documented
potential.
In
current
study
we
focused
on
evaluation
potential
agent
against
MQRInvestigar,
Год журнала:
2024,
Номер
8(3), С. 2250 - 2271
Опубликована: Авг. 2, 2024
La
tasa
de
filtración
glomerular
y
la
cistatina
C
son
marcadores
importantes
que
se
utilizaron
para
evaluar
función
detectar
daño
renal,
generalmente
causado
por
diversos
factores
como
hipertensión
diabetes.
El
estudio
tuvo
objetivo
demostrar
renal:
causa
estadificación
en
población
mundial,
empleó
una
metodología
documental,
exploratoria
nivel
explicativo.
Entre
los
resultados
destacó
el
renal
podía
ser
varios
factores,
edad
género,
presión
arterial
elevada,
diabetes
mellitus,
hemorragias
dilataciones;
modificación
dieta
enfermedades
renales
colaboración
epidemiología
enfermedad
crónica,
ecuación
Schwartz
las
ecuaciones
Cockcroft-Gault
Jelliffe
modificada
fueron
más
utilizadas
medir
glomerular;
niveles
normales
oscilaron
entre
0.6
1.3,
sin
embargo,
estos
podían
elevarse
hasta
4
mg/L
ante
algún
acontecimiento
patológico;
mayoría
participantes
mostraron
tener
normal
o
aumentada,
otra
minoría
mostró
estar
G2
proporción
pequeña
G4
G5.
Se
concluyó
condiciones
crónicas
emergieron
contribuyentes
renal;
evaluación
a
través
varias
ofreció
herramienta
valiosa
comprender
diversa
mundial.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(18), С. 9826 - 9826
Опубликована: Сен. 11, 2024
Itaconic
acid
(IA)
is
recognized
for
its
potential
application
in
treating
intestinal
diseases
owing
to
the
anti-inflammatory
and
antioxidant
properties.
Perfluorooctanoic
(PFOA)
can
accumulate
animals
result
oxidative
inflammatory
damages
multi-tissue
organ,
particularly
tract.
This
study
aimed
explore
whether
IA
could
mitigate
damage
induced
by
PFOA
exposure
laying
hens
elucidate
underlying
mechanisms.
The
results
showed
that
improved
capacity
of
alleviated
PFOA,
as
evidenced
elevated
activities
T-SOD,
GSH-Px,
CAT,
decreased
MDA
content
both
jejunum
serum.
Furthermore,
morphological
structural
integrity,
notably
attenuating
PFOA-induced
villus
shedding,
length
reduction,
microvillus
thinning.
also
upregulated
mRNA
expression
