Chitosan- and hyaluronic acid-based nanoarchitectures in phototherapy: Combination cancer chemotherapy, immunotherapy and gene therapy
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
273, С. 132579 - 132579
Опубликована: Май 23, 2024
Язык: Английский
Bee Pollen Phytochemicals and Nutrients as Unequaled Pool of Epigenetic Regulators: Implications for Age-Related Diseases
Foods,
Год журнала:
2025,
Номер
14(3), С. 347 - 347
Опубликована: Янв. 21, 2025
Bee
pollen
is
characterized
by
an
exceptional
diversity
and
abundance
of
micronutrients
bioactive
phytochemicals.
This
richness
remains
very
sparsely
investigated,
but
accumulating
evidence
strongly
supports
a
promising
future
for
bee
in
human
nutrition
medicine.
Epigenetic
regulation
among
the
most
compelling
biomedical
topics
that
remain
completely
untapped
derivative
research.
In
our
current
research,
we
identified
numerous
ubiquitous
compounds
are
consistently
present
this
matrix,
regardless
its
botanical
geographical
origins,
have
been
well
studied
documented
as
epigenetic
regulators
recent
years.
Given
relative
newness
both
research
studies
within
nutritional,
pharmaceutical,
medical
sciences,
review
aims
to
bridge
these
valuable
fields
advance
related
experimental
investigations.
To
best
knowledge,
first
work
has
aimed
comprehensively
investigate
modulatory
potential
compounds.
Our
findings
also
unveiled
several
intriguing
phenomena,
such
dual
effect
same
compound
depending
on
cellular
context
or
some
cross-generational
heritability
traits.
Although
whole
extract
still
lacking,
study
clearly
indicates
avenue
worth
further
We
hope
constitutes
foundational
cornerstone
investigations
Язык: Английский
Glutathione‑degrading enzymes in the complex landscape of tumors (Review)
International Journal of Oncology,
Год журнала:
2024,
Номер
65(1)
Опубликована: Июнь 3, 2024
Glutathione
(GSH)‑degrading
enzymes
are
essential
for
starting
the
first
stages
of
GSH
degradation.
These
include
extracellular
γ‑glutamyl
transpeptidase
(GGT)
and
intracellular
GSH‑specific
γ‑glutamylcyclotransferase
1
(ChaC1)
2.
cellular
activities,
such
as
immune
response,
differentiation,
proliferation,
homeostasis
regulation
programmed
cell
death.
Tumor
tissue
frequently
exhibits
abnormal
expression
GSH‑degrading
enzymes,
which
has
a
key
impact
on
development
spread
malignancies.
The
present
review
summarizes
gene
protein
structure,
catalytic
activity
their
vital
roles
in
tumor
(including
oxidative
endoplasmic
reticulum
stress,
control
death,
promotion
inflammation
tumorigenesis
modulation
drug
resistance
cells)
potential
role
diagnostic
biomarkers
therapeutic
targets.
Язык: Английский
Exploring mechanisms of britannin against colorectal cancer based on experimentally validated network pharmacology
Xiaoli Liu,
Qiuxia Ye,
Mengdi Hao
и другие.
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 13, 2025
Язык: Английский
Therapeutic Potential of Terpenoids in Cancer Treatment: Targeting Mitochondrial Pathways
Cancer Reports,
Год журнала:
2024,
Номер
7(9)
Опубликована: Сен. 1, 2024
ABSTRACT
Background
In
recent
decades,
natural
compounds
have
been
considered
a
significant
source
of
new
antitumor
medicines
due
to
their
unique
advantages.
Several
in
vitro
and
vivo
studies
focused
on
the
effect
terpenoids
apoptosis
mediated
by
mitochondria
malignant
cells.
Recent
findings
this
review
article,
we
six
extensively
studied
terpenoids,
including
sesquiterpenes
(dihydroartemisinin
parthenolide),
diterpenes
(oridonin
triptolide),
triterpenes
(betulinic
acid
oleanolic
acid),
efficacy
targeting
induce
cell
death.
Terpenoid‐induced
mitochondria‐related
death
includes
apoptosis,
pyroptosis,
necroptosis,
ferroptosis,
autophagy,
necrosis
caused
mitochondrial
permeability
transition.
Apoptosis
autophagy
interact
meaningful
ways.
addition,
view
several
disadvantages
such
as
low
stability
bioavailability,
advances
research
combination
chemotherapy
chemical
modification
were
surveyed.
Conclusion
This
article
deepens
our
understanding
association
between
death,
presenting
hypothetical
basis
for
use
anticancer
management.
Язык: Английский
In Vitro Protective Effects of a Standardized Extract of Opuntia ficus-indica (L.) Mill. Cladodes and Olea europaea L. Leaves Against Indomethacin-Induced Intestinal Epithelial Cell Injury
Antioxidants,
Год журнала:
2024,
Номер
13(12), С. 1507 - 1507
Опубликована: Дек. 10, 2024
Nonsteroidal
anti-inflammatory
drugs
(NSAIDs)
can
induce
serious
adverse
effects
in
gastrointestinal
(GI)
mucosa,
increasing
intestinal
permeability
and
leading
to
mitochondrial
dysfunction,
oxidative
stress,
apoptosis
inflammation.
As
proton
pump
inhibitors
are
effective
protecting
against
NSAID-induced
gastropathy
but
not
enteropathy,
current
research
is
focused
on
natural
products
as
protective
substances
for
therapy
prevention
of
injury.
Herein,
through
the
use
an
vitro
model
based
epithelial
cell
(Caco-2)
damage
caused
by
indomethacin
(INDO),
we
examined
activity
a
commercially
available
standardized
extract
(OFI+OE)
from
Opuntia
ficus-indica
(L.)
Mill.
cladodes
Olea
europaea
L.
leaves.
Pre-treatment
with
OFI+OE
prevented
INDO-induced
barrier
damage,
demonstrated
TEER
measurement,
fluorescein
permeability,
tight
junction
protein
expression.
The
showed
positive
stress
correlated
activation
apoptosis,
decreasing
pro-apoptotic
markers
BAX
Caspase-3
anti-apoptotic
factor
Bcl-2.
Moreover,
inhibited
NF-κB
pathway
pro-inflammatory
cascade.
In
conclusion,
these
data
support
strategy
mucosal
demonstrating
its
beneficial
modulation
oxidative,
apoptotic,
inflammatory
pathways.
Язык: Английский