Journal of Herbal Medicine, Год журнала: 2024, Номер unknown, С. 100955 - 100955
Опубликована: Окт. 1, 2024
Язык: Английский
Cells, Год журнала: 2024, Номер 13(13), С. 1098 - 1098
Опубликована: Июнь 25, 2024
Migraine is a debilitating neurological disorder characterized by recurring episodes of throbbing headaches that are frequently accompanied sensory disturbances, nausea, and sensitivity to light sound [...]
Язык: Английский
Процитировано
13
Journal of Neural Transmission, Год журнала: 2024, Номер 131(12), С. 1367 - 1387
Опубликована: Авг. 7, 2024
Millions of individuals around the world are afflicted with Parkinson's disease (PD), a prevalent and incapacitating neurodegenerative disorder. Dr. Reichmann, distinguished professor neurologist, has made substantial advancements in domain PD research, encompassing both fundamental scientific investigations practical applications. His research illuminated etiology treatment PD, as well function energy metabolism premotor symptoms. As precursor to number neurotransmitters neuromodulators that implicated pathophysiology he also investigated application tryptophan (Trp) derivatives disease. principal findings insights summarized synthesized this narrative review article, which emphasizes challenges implications for future research. This aims identify analyze key contributions Reichmann field ultimate goal informing directions domain. By examining Reichmann's work, study seeks provide comprehensive understanding his major how they can be applied advance diagnosis PD. paper explores potential intersection emerging avenues, such investigation Trp its metabolites, particularly kynurenines, could lead new therapeutic strategies managing disorders like
Язык: Английский
Процитировано
9
Nutrients, Год журнала: 2024, Номер 16(16), С. 2721 - 2721
Опубликована: Авг. 15, 2024
Aging-related disorders pose significant challenges due to their complex interplay of physiological and metabolic factors, including inflammation, oxidative stress, mitochondrial dysfunction. Curcumin, a natural compound with potent antioxidant anti-inflammatory properties, has emerged as promising candidate for mitigating these age-related processes. However, gaps in understanding the precise mechanisms curcumin’s effects optimal dosages different conditions necessitate further investigation. This systematic review synthesizes current evidence on potential addressing disorders, emphasizing its impact cognitive function, neurodegeneration, muscle health older adults. By evaluating safety, efficacy, action curcumin supplementation, this aims provide insights into therapeutic promoting healthy aging. A search across three databases using specific keywords yielded 2256 documents, leading selection 15 clinical trials synthesis. Here, we highlight multifaceted agent combating disorders. The findings suggest that could offer effective approach enhancing quality life aging individuals. Further research well-designed are essential validate optimize use personalized medicine approaches conditions.
Язык: Английский
Процитировано
8
Pharmaceuticals, Год журнала: 2024, Номер 17(10), С. 1354 - 1354
Опубликована: Окт. 10, 2024
Metabolic-Associated Fatty Liver Disease (MAFLD) is a clinical-pathological scenario that occurs due to the accumulation of triglycerides in hepatocytes which considered significant cause liver conditions and contributes an increased risk death worldwide. Even though possible causes MAFLD can involve interaction genetics, hormones, nutrition, lifestyle (diet sedentary lifestyle) most influential factor developing this condition. Polyphenols comprise many natural chemical compounds be helpful managing metabolic diseases. Therefore, aim review was investigate impact oxidative stress, inflammation, mitochondrial dysfunction, role polyphenols MAFLD. Some reverse part damage related or among them are anthocyanin, baicalin, catechin, curcumin, chlorogenic acid, didymin, epigallocatechin-3-gallate, luteolin, mangiferin, puerarin, punicalagin, resveratrol, silymarin. These have actions reducing plasma enzymes, body mass index, waist circumference, adipose visceral indices, lipids, glycated hemoglobin, insulin resistance, HOMA index. They also reduce nuclear factor-KB (NF-KB), interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), blood pressure, fat content, steatosis fibrosis. On other hand, they improve HDL-c, adiponectin levels, fibrogenesis markers. results show promising prevention treatment
Язык: Английский
Процитировано
6
Biomedicines, Год журнала: 2024, Номер 12(9), С. 2096 - 2096
Опубликована: Сен. 13, 2024
The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating the mass reduction seen in sarcopenia neuronal function characteristic neurodegeneration. Our limited understanding intricate relationships within this hinders accurate diagnosis effective treatment strategies. This review analyzes interrelated mechanisms contribute to these conditions, with a specific focus on oxidative stress, chronic inflammation, impaired nutrient delivery. aim is understand common pathways involved suggest comprehensive therapeutic approaches. dysfunctions hinder circulation transportation nutrients, resulting characterized by atrophy weakness. dysfunction have negative physical quality life. Neurodegenerative diseases exhibit comparable pathophysiological affect motor functions. Preventive approaches encompass lifestyle adjustments, addressing integrated therapies improving muscular well-being. Better links can refine strategies yield better patient outcomes. study emphasizes complex interplay between dysfunction, degeneration, decline, highlighting necessity for multidisciplinary Advances domain promise improved diagnostic accuracy, more options, enhanced preventive measures, all contributing higher life elderly population.
Язык: Английский
Процитировано
5
Journal of Chromatography Open, Год журнала: 2025, Номер unknown, С. 100209 - 100209
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер 398(1), С. 165 - 177
Опубликована: Авг. 13, 2024
Язык: Английский
Процитировано
4
Prostaglandins & Other Lipid Mediators, Год журнала: 2025, Номер unknown, С. 106992 - 106992
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Revista de Gestão e Secretariado (Management and Administrative Professional Review), Год журнала: 2024, Номер 15(7), С. e3884 - e3884
Опубликована: Июль 15, 2024
O óleo de semente romã (PSO) é reconhecido por seus benefícios em aplicações biomédicas devido à presença compostos como ácido púnico e ursólico, que demonstraram eficácia no combate a processos antitumorais anti-inflamatórios. Sua utilização tem sido explorada tratamento diversos tipos câncer, incluindo mama, bexiga, pele, próstata, cólon visão, destacando-se sua capacidade induzir apoptose bloquear o ciclo celular das células tumorais. Além disso, atividade anti-inflamatória antioxidante torna promissor doenças neurológicas, esclerose múltipla, demência declínio cognitivo. A pesquisa bibliográfica abrangeu um período cinco anos (2019-2024), utilizando plataformas científicas Science Direct PubMed, concentrou-se fornecer levantamento abrangente atualizado sobre as terapêuticas do romã. Os estudos revisados destacaram vasto potencial terapêutico da romã, especialmente aos polifenóis, evidenciando prevenção várias doenças, cognitivo, metabólicas inflamatórias. Após uma rigorosa seleção artigos, apenas 29 foram considerados alta qualidade relevância para discussão final. Esses forneceram base sólida avanços futuros campo biomédico, destacando importância opção promissora diversas terapêuticas.
Процитировано
0
Food Reviews International, Год журнала: 2024, Номер unknown, С. 1 - 23
Опубликована: Сен. 5, 2024
Язык: Английский
Процитировано
0