Journal of Biosafety and Biosecurity, Год журнала: 2024, Номер 6(4), С. 265 - 270
Опубликована: Ноя. 7, 2024
Язык: Английский
Viruses, Год журнала: 2024, Номер 16(2), С. 184 - 184
Опубликована: Янв. 25, 2024
Over the last three years, pandemic of COVID-19 has had a significant impact on people’s lives and global economy. The incessant emergence variant strains compounded challenges associated with management COVID-19. As predominant from late 2021 to present, Omicron its sublineages, through continuous evolution, have demonstrated iterative viral fitness. comprehensive elucidation biological implications that catalyzed this evolution remains incomplete. In accordance extant research evidence, we provide review subvariants Omicron, delineating alterations in immune evasion, cellular infectivity, cross-species transmission potential. This seeks clarify underpinnings biology within SARS-CoV-2, thereby providing foundation for strategic considerations post-pandemic era
Язык: Английский
Процитировано
23
Infectious Disease Modelling, Год журнала: 2024, Номер 9(3), С. 728 - 743
Опубликована: Апрель 22, 2024
The structure of age groups and social contacts the total population influenced infection scales hospital-bed requirements, especially severe infections deaths during global prevalence COVID-19. Before end year 2022, Chinese government implemented national vaccination had built herd immunity cross country, announced Twenty Measures (November 11) Ten New (December 7) for further modifications dynamic zero-COVID polity on mainland. With nation-wide modified measures background, Fuzhou COVID-19 large wave 19, 2022–February 9, 2023) led by Omicron BA.5.2 variant was recorded prevailed three months in Fujian Province. A multi-age susceptible-exposed-infected-hospitalized-recovered (SEIHR) model with proposed this study. main object to evaluate impacts population. idea Least Squares method governed perform data fittings four against surveillance from Provincial Center Disease Control Prevention (Fujian CDC). next generation matrix used compute basic reproduction number specific group. tendencies effective were plotted using Epiestim R package SEIHR in-depth discussions. sensitivity analysis index partial rank correlation coefficients values (PRCC values) operated reveal differences parameters. epidemiological features such as number, extensively discussed Firstly, method, R0 estimated 1.57 parameter wave. Given group k, R0k (age k k), (an infected population) R^0k k) also estimated, which explorations revealed that relationship R0k>R0k>R^0k valid. Then, fluctuating Rt demonstrated two approaches (the model) wave, high-risk (G4 group) mainly contributed scale due high susceptibility risks diseases. Further, PRCC played vital roles, while numerical simulation showed varied changes groups. results study claimed out concerned local highest This verified partition population, groups, among important contributors scale. less adequate hospital beds profitable control spread To avoid emergence medical runs new future, policymakers suggested decline when limited.
Язык: Английский
Процитировано
6
Water, Год журнала: 2024, Номер 16(9), С. 1220 - 1220
Опубликована: Апрель 25, 2024
Background: Wastewater-based epidemiology (WBE) has become crucial for early microbial outbreak detection and public health surveillance globally, underscored by the COVID-19 pandemic. However, despite advancements in sampling analyses, interpreting results estimating infection rates pose challenges. Enhancements sewer system engineering, understanding wastewater environment, addressing impact of environment on accuracy are needed. Objective: This scoping review aims to identify engineering knowledge gaps WBE guide future study designs. Design: Research “wastewater-based epidemiology” involving “engineering”, published between 2015 2023, was extracted from Scopus database. Results: examines elements influencing WBE’s precision reliability, especially identifying measuring SARS-CoV-2 RNA. It identifies significant effects analytical practices, wastewater’s composition performance. Conclusions: calls further investigation into economical evaluation methods these factors enhance data normalization interpretation, utilizing existing treatment plant used control, which could be a cost-effective approach over more expensive population biomarkers. approach, aside SARS-CoV-2, holds potential application broader number types diseases, as well consumption habits.
Язык: Английский
Процитировано
6
Applied Mathematical Modelling, Год журнала: 2025, Номер unknown, С. 116152 - 116152
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Journal of Medical Virology, Год журнала: 2024, Номер 96(2)
Опубликована: Фев. 1, 2024
Abstract A state‐wide prospective longitudinal investigation of the genomic surveillance omicron B.1.1.529 SARS‐CoV‐2 variant and its sublineages in Tamil Nadu, India, was conducted between December 2021 March 2023. The study aimed to elucidate their mutational patterns genetic interrelationship Indian population. identified several unique mutations at different time‐points, which likely could attribute changing disease characteristics, transmission, pathogenicity attributes variants. found that is highly competent mutating potentials, it continues evolve general population, escaping from natural as well vaccine‐induced immune responses. Our findings suggest continuous viral variants global scenario warranted undertake intervention measures against potentially precarious evolution.
Язык: Английский
Процитировано
3
Infectious Disease Modelling, Год журнала: 2024, Номер 9(3), С. 689 - 700
Опубликована: Март 30, 2024
The complex interactions were performed among non-pharmaceutical interventions, vaccinations, and hosts for all epidemics in mainland China during the spread of COVID-19. Specially, small-scale epidemic city described by SVEIR model was less found current studies. with control established to analyze dynamical epidemiological features two Jinzhou City led Omicron variants before after Twenty Measures. In this study, total population (N) divided into five compartments: susceptible (S), vaccinated (V), exposed (E), infected (I), recovered (R). By surveillance data model, three methods (maximum likelihood method, exponential growth rate next generation matrix method) governed estimate basic reproduction number, results showed that an increasing tendency number from BA.5.2 BA.2.12.1. Meanwhile, effective investigated data, wave 1 reached peak on November 4 controlled 3 days later, 2 28 5 later. Moreover, impacts interventions (awareness delay, intensity) discussed extensively, variations infection scales variant EG.5 also discussed. Furthermore, investigations peaks dynamic zero-COVID policy operated control. public medical requirements Liaoning Province analyzed using without control, which provided a possible perspective evolution future.
Язык: Английский
Процитировано
3
Journal of Biosafety and Biosecurity, Год журнала: 2024, Номер 6(2), С. 67 - 75
Опубликована: Апрель 15, 2024
The epidemiological characteristics and distributions of two epidemics in Fujian Province Southeast China were attributed to the complex interactions among variant, host, non-pharmaceutical interventions (NPIs). All reported cases Putian epidemic (September 8–October 2, 2021, Delta variant B.1.617.2) Fuzhou (October 22–November 18, 2022, Omicron BA.5.2) classified by sex, age group, occupation, location this study. Using surveillance data from Provincial Center for Disease Control Prevention, we established a virus-oriented SVEIR (Susceptible–Vaccinated–Exposed–Infected–Recovered) model investigate dynamic evolution features these variants effects NPIs. optimal simulations carried out with scenario investigations. investigations showed that NPIs significantly reduced transmission risk infection scales COVID-19, was more infectious than variant. Moreover, revealed increasing tendencies Omicron, such as basic reproduction number, rate, percentage high-risk cases, growth rate. Decreasing also identified, average recovery period, awareness delay, symptomatic cases. This study highlighted played critical roles successfully containing epidemics. Such are strongly recommended public health policymakers.
Язык: Английский
Процитировано
3
PLoS ONE, Год журнала: 2024, Номер 19(7), С. e0306554 - e0306554
Опубликована: Июль 5, 2024
The differences of SARS-CoV-2 variants brought the changes transmission characteristics and clinical manifestations during prevalence COVID-19. In order to explore evolution mechanisms impacts variant evolution, classic SIR (Susceptible-Infected-Recovered) compartment model was modified a generalized SVEIR (Susceptible-Vaccinated-Exposed-Infected-Recovered) with age-group varying in this study. By using least squares method, optimal fittings against surveillance data from Fujian Provincial Center for Disease Control Prevention were performed five epidemics Province. main epidemiological such as basic reproduction number, effective sensitivity analysis, cross-variant scenario investigations extensively investigated dynamic zero-COVID policy. study results showed that infectivities became fast wild strain Delta variant, further Omicron variant. Meanwhile, average incubation periods shortened, infection scales quickly enhanced. Further, risk estimations new without implements non-pharmaceutical interventions, based on dominant XBB.1.9.1 EG.5. suggested interventions necessary Chinese mainland controlling severe infections deaths, also regular monitors still workable aggressive emergency risks future.
Язык: Английский
Процитировано
2
Infectious Disease Modelling, Год журнала: 2024, Номер 10(1), С. 207 - 228
Опубликована: Окт. 10, 2024
As of May 2024, the main strains COVID-19 caused hundreds millions infection cases and deaths worldwide. In this study, we consider epidemics with in Chinese mainland. We study complex interactions among hosts, non-pharmaceutical interventions, vaccinations for by a differential equation model called SVEIR. The disease transmission incorporates two protection awareness susceptible population. Results show that plays crucial role against population, vaccines are effective circulation earlier strains, but ineffective emerging strains. By using next generation matrix method, basic reproduction number SVEIR is firstly obtained. Our analysis Hurwitz criterion LaSalle's invariance principle shows free-equilibrium point locally globally asymptotically stable when threshold value below one. existences endemic equilibrium points also established, global asymptotic stabilities analyzed Lyapunov function method. Further, confirmed to satisfy competitive exclusion, which strain larger dominant. Numerically, surveillance data Omicron XBB split cubic spline interpolation fitting curves plotted least-squares method from MATLAB. results indicate dominates study. Moreover, sensitivity key parameters performed PRCC. numerical simulations imply combination control strategy positively impacts on scale than what separate does, time producing public creates less scale, further increment reduces scale. Therefore, policymakers local government suggested concern changes public.
Язык: Английский
Процитировано
0
Journal of Biosafety and Biosecurity, Год журнала: 2024, Номер 6(4), С. 265 - 270
Опубликована: Ноя. 7, 2024
Язык: Английский
Процитировано
0