Chemical composition of leaf essential oil of Schinopsis lorentzii and its inhibitory effects against key enzymes relevant to type-2 diabetes: an emphasis on GC-MS chemical profiling and molecular docking studies
Journal of Essential Oil Bearing Plants,
Год журнала:
2024,
Номер
27(3), С. 731 - 743
Опубликована: Май 3, 2024
AbstractSchinopsis
lorentzii
(Griseb.)
Engler
is
an
aromatic
plant
belonging
to
Anacardiaceae
family,
and
grown
in
Argentina,
Paraguay,
Brazil,
Bolivia.
It
a
rich
source
of
essential
oils
tannins
as
well
commercially
available
vegetable-processed
leather
tanning
antiparasitic
agent.
This
study
was
designed
explore
the
chemical
composition
oil
isolated
from
S.
leaves
elaborate
on
their
significance
natural
anti-diabetic,
combined
with
molecular-docking
studies.
The
leaf
chemically
analysed
using
gas
chromatography-mass
spectrometry
(GC-MS)
method
investigated
for
inhibitory
effects
against
α-amylase
α-glucosidase.
Molecular-modelling
via
Molecular
Operating
Environment-Docking
(MOE-Dock)
program
used
evaluate
binding
interactions
major
components
above-mentioned
targets.
GC-MS
analysis
revealed
predominance
β-caryophyllene
(21.63±0.36%),
γ-terpinene
(13.53±0.74%),
α-pinene
(13.38±0.65%),
terpinen-4-ol
(12.55±1.56%).
tested
expressed
remarkable
effect
IC50
value
2.27±0.19
μg/mL,
comparable
acarbose
(IC50
=
0.52±0.18
μg/mL)
standard
drug.
Similarly,
it
significantly
inhibited
α-glucosidase
0.84±0.03
μg/mL),
compared
0.38±0.02μg/mL).
in-silico
molecular
docking
favorable
affinities
β-caryophyllene,
sabinene
variable
degrees
Thus,
this
demonstrated
valuable
scientific
data
potential
candidate
development
antidiabetic
formulations.Keywords:
Antidiabeticα-AmylaseCaryophylleneα-GlucosidaseSchinopsis
Язык: Английский
Therapeutic Potential of Terpenoids in Cancer Treatment: Targeting Mitochondrial Pathways
Cancer Reports,
Год журнала:
2024,
Номер
7(9)
Опубликована: Сен. 1, 2024
ABSTRACT
Background
In
recent
decades,
natural
compounds
have
been
considered
a
significant
source
of
new
antitumor
medicines
due
to
their
unique
advantages.
Several
in
vitro
and
vivo
studies
focused
on
the
effect
terpenoids
apoptosis
mediated
by
mitochondria
malignant
cells.
Recent
findings
this
review
article,
we
six
extensively
studied
terpenoids,
including
sesquiterpenes
(dihydroartemisinin
parthenolide),
diterpenes
(oridonin
triptolide),
triterpenes
(betulinic
acid
oleanolic
acid),
efficacy
targeting
induce
cell
death.
Terpenoid‐induced
mitochondria‐related
death
includes
apoptosis,
pyroptosis,
necroptosis,
ferroptosis,
autophagy,
necrosis
caused
mitochondrial
permeability
transition.
Apoptosis
autophagy
interact
meaningful
ways.
addition,
view
several
disadvantages
such
as
low
stability
bioavailability,
advances
research
combination
chemotherapy
chemical
modification
were
surveyed.
Conclusion
This
article
deepens
our
understanding
association
between
death,
presenting
hypothetical
basis
for
use
anticancer
management.
Язык: Английский
Nutritional composition, phytochemical profile, and health benefits of Hylocereus Undatus (pitaya): A comprehensive review
eFood,
Год журнала:
2024,
Номер
5(5)
Опубликована: Окт. 1, 2024
Abstract
Hylocereus
undatus
,
occasionally
referred
to
as
the
dragon
fruit
or
white‐fleshed
pitaya,
is
a
rich
in
nutrients
appreciated
because
of
its
colorful
look
and
health
benefits.
It
inexpensive
calories
but
packed
with
minerals
like
iron,
magnesium,
calcium
addition
essential
vitamin
C
B
vitamins.
Similarly
dietary
fiber,
particularly
promotes
gut
wellness
improves
digestion,
pitaya.
additionally
contains
antioxidants,
such
phenolic
compounds,
flavonoids,
betalains,
which
help
scavenging
free
radicals
reducing
detrimental
effects
oxidative
stress
on
human
body.
The
substantial
amount
betalains
phytochemical
composition
notable
it
contributes
plant's
anti‐inflammatory
antioxidant
properties.
There
has
been
an
association
among
these
phytochemicals
decreased
likelihood
contracting
long‐term
conditions
diabetes,
cancer,
cardiovascular
disease.
Omega‐3
fatty
acids
omega‐6
acids,
particular,
that
reduce
cholesterol
levels
while
improving
blood
circulation,
are
plentiful
fruit's
seeds
beneficial
heart
wellness.
objective
this
review
highlight
nutritional
profile,
benefits
detail.
Язык: Английский
Botanical Sources, Pharmacokinetics, and Therapeutic Efficacy of Palmatine and Its Derivatives in the Management of Cancer: A Comprehensive Mechanistic Analysis
Journal of Food Biochemistry,
Год журнала:
2024,
Номер
2024(1)
Опубликована: Янв. 1, 2024
Natural
compounds
and
their
derivatives
have
been
identified
as
valuable
sources
of
therapeutic
ingredients
for
cancer
treatment.
The
naturally
occurring
phytochemical
palmatine
(isoquinoline
alkaloid)
is
extracted
from
plant
parts
(rhizomes,
roots,
stems,
stem
barks,
others)
has
protective
effects
including
antioxidant,
anti‐inflammatory,
anticancer.
This
study
aims
to
summarize
the
anticancer
potential
its
in
treatment
numerous
types
with
molecular
mechanisms.
We
also
include
pharmacokinetic
features,
botanical
origin,
toxicological
characteristics
derivatives.
For
this,
data
collected
plausible
different
electronic
databases,
PubMed,
Google
Scholar,
PubChem,
Science
Direct,
Web
Science,
Scopus,
Springer
Link,
Wiley
Online.
findings
demonstrate
that
a
effect
against
variety
cancers,
breast,
colorectal,
gastric,
ovarian,
prostate,
pancreatic,
skin,
hepatocellular
cancer,
mammary
gland
tumors.
They
provoke
properties
various
cell
lines
via
modifying
mechanisms
like
induction
oxidative
stress,
cytotoxicity,
apoptosis,
inhibition
invasion
migration,
arresting
cycle
at
S
phase,
antiproliferative,
antiangiogenic
effects.
It
suggested
may
be
good
option
development
novel
drugs
therapy
future.
Язык: Английский
Promising and challenging phytochemicals targeting LC3 mediated autophagy signaling in cancer therapy
Immunity Inflammation and Disease,
Год журнала:
2024,
Номер
12(10)
Опубликована: Окт. 1, 2024
Abstract
Background
Phytochemicals
possess
a
wide
range
of
anti‐tumor
properties,
including
the
modulation
autophagy
and
regulation
programmed
cell
death.
Autophagy
is
critical
process
in
cellular
homeostasis
its
dysregulation
associated
with
several
pathological
conditions,
such
as
cancer,
neurodegenerative
diseases,
diabetes.
In
plays
dual
role
by
either
promoting
tumor
growth
or
suppressing
it,
depending
on
context.
During
autophagy,
autophagosomes
engulf
cytoplasmic
components
proteins
organelles.
LC3‐II
(microtubule‐associated
protein
1
light
chain
3‐II)
an
established
marker
autophagosome
formation,
making
it
central
to
monitoring
mammals.
Objective
To
explore
regulatory
phytochemicals
LC3‐mediated
their
potential
therapeutic
impact
cancer.
The
review
emphasizes
involvement
promotion
suppression,
particularly
focusing
autophagy‐related
signaling
pathways
like
oxidative
stress
through
NRF2
pathway,
implications
for
genomic
stability
cancer
development.
Methods
focuses
comprehensive
analysis
bioactive
compounds
Curcumin,
Celastrol,
Resveratrol,
Kaempferol,
Naringenin,
Carvacrol,
Farnesol,
Piperine.
Literature
these
was
examined
assess
influence
LC3
expression,
tumor‐related
pathways.
A
systematic
literature
search
conducted
across
databases
PubMed,
Scopus,
Web
Science
from
inception
2023.
Studies
were
selected
prominent
databases,
roles
diagnosis
interventions,
relation
mechanisms.
Results
have
been
shown
modulate
levels
autophagic
flux
cells.
interaction
between
other
stress,
inflammation,
epigenetic
highlights
complex
biology.
For
instance,
Curcumin
Resveratrol
reported
induce
inhibit
type,
influencing
progression
responses.
Conclusion
Targeting
presents
promising
strategy
therapy.
suppression
promotion,
however,
necessitates
careful
consideration
context
which
induced
inhibited.
Future
research
should
aim
delineate
context‐specific
how
can
be
optimized
efficacy.
Novel
strategies
focus
use
fine‐tune
thereby
maximizing
inducing
death
Язык: Английский
Phytochemicals from Cactaceae family for cancer prevention and therapy
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 24, 2024
Cancer
is
a
global
health
issue,
increasingly
prevalent
and
leading
cause
of
mortality.
Despite
extensive
research,
conventional
treatments
remain
aggressive,
often
damaging
healthy
cells,
exhibit
limited
efficacy.
Addressing
drug
resistance
enhancing
treatment
effectiveness
are
critical
challenges
in
advancing
cancer
therapy.
This
review
examines
the
potential
natural
plant
compounds,
particularly
phytochemicals
their
derivatives,
developing
novel
anticancer
agents.
These
metabolites
have
long
history
traditional
medicine,
with
42%
molecules
approved
for
between
1981
2019
being
either
products
or
derivatives.
The
Cactaceae
family,
which
comprises
more
than
1,500
species,
represents
largely
untapped
source
potentially
useful
chemopreventive
Although
3,000
plants
derivatives
contributed
to
chemotherapeutic
development,
cactus
species
received
attention
until
recently.
Emerging
evidence
highlights
fruits,
stems,
cladodes
from
various
species.
provides
comprehensive
current
overview
experimental
studies
on
aiming
pave
way
development
innovative,
therapeutics
contribute
ongoing
battle
against
this
formidable
disease.
Язык: Английский