International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
26(1), С. 127 - 127
Опубликована: Дек. 26, 2024
Breast
cancer
(BC)
is
one
of
the
most
prevalent
forms
globally,
and
has
recently
become
leading
cause
cancer-related
mortality
in
women.
BC
a
heterogeneous
disease
comprising
various
histopathological
molecular
subtypes
with
differing
levels
malignancy,
each
patient
an
individual
prognosis.
Etiology
pathogenesis
are
complex
involve
considerable
number
genetic
alterations
dozens
non-coding
RNA
expression.
Non-coding
RNAs
part
abundant
family
single-stranded
molecules
acting
as
key
regulators
DNA
replication,
mRNA
processing
translation,
cell
differentiation,
growth,
overall
genomic
stability.
In
context
breast
cancer,
involved
cycle
control
tumor
migration
invasion,
well
treatment
resistance.
Alterations
expression
may
contribute
to
development
progression
making
them
promising
biomarkers
targets
for
novel
therapeutic
approaches.
Currently,
use
not
yet
been
applied
routine
practice;
however,
their
potential
very
studied.
The
present
review
literature
overview
current
knowledge
its
objective
delineate
function
diverse
classes
particular
emphasis
on
utility
diagnostic
prognostic
markers
or
tools.
The
intricate
relationship
between
cancer,
circadian
rhythms,
and
aging
is
increasingly
recognized
as
a
critical
factor
in
understanding
the
mechanisms
underlying
tumorigenesis
cancer
progression.
Aging
well-established
primary
risk
for
while
disruptions
rhythms
are
intricately
associated
with
progression
of
various
tumors.
Moreover,
itself
disrupts
leading
to
physiological
changes
that
may
accelerate
development.
Despite
these
connections,
specific
interplay
processes
their
collective
impact
on
remains
inadequately
explored
literature.
In
this
review,
we
systematically
explore
influence
We
discuss
how
core
genes
tumor
prognosis,
highlighting
shared
hallmarks
such
genomic
instability,
cellular
senescence,
chronic
inflammation.
Furthermore,
examine
aging,
focusing
crosstalk
contributes
tumorigenesis,
proliferation,
apoptosis,
well
metabolism
stability.
By
elucidating
common
pathways
linking
review
provides
new
insights
into
pathophysiology
identifies
potential
therapeutic
strategies.
propose
targeting
regulation
could
pave
way
novel
treatments,
including
chronotherapy
antiaging
interventions,
which
offer
important
benefits
clinical
management
cancer.
Biomarker Research,
Год журнала:
2025,
Номер
13(1)
Опубликована: Янв. 23, 2025
Abstract
Background
Myelodysplastic
neoplasms
(MDS)
are
heterogeneous
hematopoietic
disorders
characterized
by
ineffective
hematopoiesis
and
genome
instability.
Mobilization
of
transposable
elements
(TEs)
is
an
important
source
instability
leading
to
oncogenesis,
whereas
small
PIWI-interacting
RNAs
(piRNAs)
act
as
cellular
suppressors
TEs.
However,
the
roles
TEs
piRNAs
in
MDS
remain
unclear.
Methods
In
this
study,
we
examined
TE
piRNA
expression
through
parallel
RNA
sequencing
CD34+
stem
cells
from
patients.
Results
Comparative
analysis
between
control
samples
revealed
several
significantly
dysregulated
molecules.
significant
differences
were
observed
lower-risk
(LR-MDS)
higher-risk
(HR-MDS)
samples.
HR-MDS,
found
inverse
correlation
decreased
levels
increased
these
associated
with
patient
outcomes.
Importantly,
upregulation
PIWIL2
,
which
encodes
a
key
factor
pathway,
independently
predicted
poor
prognosis
patients,
underscoring
its
potential
valuable
disease
marker.
Furthermore,
pathway
data
that
dysregulation
TE‒piRNA
axis
linked
suppression
processes
related
energy
metabolism,
cell
cycle,
immune
response,
suggesting
disruptions
affect
activity.
Conclusions
Our
findings
demonstrate
HR-MDS
highlighting
their
role
progression
indicating
level
promising
molecular
marker
for
prognosis.
Graphical
Bioengineering,
Год журнала:
2025,
Номер
12(4), С. 341 - 341
Опубликована: Март 26, 2025
Cancer
treatment
has
historically
depended
on
conventional
methods
like
chemotherapy,
radiation,
and
surgery;
however,
these
strategies
frequently
present
considerable
limitations,
including
toxicity,
resistance,
negative
impacts
healthy
tissues.
In
addressing
challenges,
drug-free
cancer
therapies
have
developed
as
viable
alternatives,
utilizing
advanced
physical
biological
to
specifically
target
tumor
cells
while
reducing
damage
normal
This
review
examines
several
strategies,
such
high-intensity
focused
energy
beams,
nanosecond
pulsed
electric
fields,
photothermal
therapy
well
the
use
of
inorganic
nanoparticles
promote
selective
apoptosis.
We
also
investigate
significance
targeting
microenvironment,
precision
medicine,
immunotherapy
in
progression
personalized
therapies.
Although
approaches
demonstrate
significant
promise,
challenges
scalability,
safety,
regulatory
obstacles
must
be
resolved
for
clinical
application.
paper
presents
an
overview
current
research
therapies,
emphasizing
recent
advancements,
underlying
scientific
principles,
steps
required
implementation.
Pharmaceuticals,
Год журнала:
2025,
Номер
18(2), С. 207 - 207
Опубликована: Фев. 3, 2025
Breast
cancer
is
the
most
common
malignancy
affecting
women,
manifesting
as
a
heterogeneous
disease
with
diverse
molecular
characteristics
and
clinical
presentations.
Recent
studies
have
elucidated
role
of
epigenetic
modifications
in
pathogenesis
breast
cancer,
including
drug
resistance
efflux
characteristics,
offering
potential
new
diagnostic
prognostic
markers,
treatment
efficacy
predictors,
therapeutic
agents.
Key
include
DNA
cytosine
methylation
covalent
modification
histone
proteins.
Unlike
genetic
mutations,
reprogramming
landscape
epigenome
promising
targeted
therapy
for
reversal
resistance.
Epidrugs,
which
target
modifications,
can
provide
novel
options
by
reversing
acquired
to
treatment.
Currently,
approach
involves
combination
therapies
consisting
epidrugs
immune
checkpoint
inhibitors.
This
review
examines
aberrant
regulation
initiation
progression,
focusing
on
related
estrogen
signaling,
resistance,
epithelial–mesenchymal
transition
(EMT).
It
existing
drugs
treating
agents
that
modify
DNA,
inhibitors
acetyltransferases,
deacetylases,
methyltransferases,
demethyltransferases.
also
delves
into
ongoing
combining
other
addresses
upcoming
obstacles
this
field.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 4, 2025
Introduction:
Gastric
cancer
(GC)
exhibits
high
invasiveness,
delayed
diagnosis,
and
poor
prognosis.
Chronic
atrophic
gastritis
(CAG),
an
initial
stage
within
the
Correa
cascade,
induces
gastric
mucosal
inflammation
atrophy,
promoting
genetic
epigenetic
alterations.
MicroRNAs
(miRNAs)
dysregulation
has
been
implicated
in
tumorigenesis,
yet
their
specific
roles
CAG
progression
to
GC
remain
unclear.
Methods:
Using
clinical
data
from
GEO
database,
we
identified
miRNAs
differentially
expressed
mucosa
serum
samples
patients.
Murine
models
were
established
through
administration
of
N-methyl-N-nitrosourea
(MNU)
high-salt
diet
(HSD).
In
vitro
functional
assays
evaluated
proliferation
migration
after
miRNA
modulation
cell
lines.
MiRNA
target
validation
involved
luciferase
reporter
assays.
Results:
MiR-3613-5p
expression
was
significantly
elevated
patients,
tissues
tumor
tissues,
human
demonstrated
increased
miR-3613-5p
following
MNU
HSD-induced
CAG.
Functionally,
overexpression
promoted
vitro,
whereas
silencing
alleviated
pathological
alterations
(atrophy,
hyperplasia,
inflammatory
infiltration)
vivo.
Mechanistically,
inhibited
Aquaporin
4
(AQP4)
by
directly
targeting
its
3'UTR.
Discussion:
Our
findings
provide
first
evidence
that
facilitates
toward
via
negative
regulation
AQP4.
These
results
highlight
as
a
promising
biomarker
therapeutic
target,
suggesting
antagomiR-3613-5p
potential
novel
strategy
prevent
carcinogenesis.
Journal of Thrombosis and Thrombolysis,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 21, 2025
Abstract
miR-27a-3p
targets
several
proteins
on
the
coagulation
cascade.
The
potential
effect
of
direct
oral
anticoagulants
(DOACs)
treatment
expression
and
their
broader
regulative
anticoagulation
is
unknown.
Fifty-nine
atrial
fibrillation
patients
treated
with
rivaroxaban
(
n
=
19),
apixaban
27)
or
dabigatran
13),
were
included
in
study.
was
analyzed
at
baseline
after
7
days
DOAC
therapy
by
using
a
predesigned
TaqMan
assay.
Relative
quantitation
calculated
compared
pooled
population
different
sample
groups.
did
not
alter
(0.80
fold-change,
p
0.486,
population;
0.839
0.706,
rivaroxaban;
0.921
0.800,
apixaban;
0.733
0.540,
dabigatran).
differ
between
controls
bleeding
cases
(0.833
0.588,
baseline).
Female
had
trend
towards
increased
(1.564
0.177)
reduced
(0.683
0.243)
to
male
patients.
Despite
regulatory
role
cascade,
DOACs
its
expression.
However,
additional
studies
ethnic
groups
are
necessary
fully
elucidate
effect,
if
any,
Graphical
