Heliyon, Journal Year: 2024, Volume and Issue: 11(1), P. e41353 - e41353
Published: Dec. 19, 2024
Language: Английский
Research, Journal Year: 2025, Volume and Issue: 8
Published: Jan. 1, 2025
The intricate relationship between cancer, circadian rhythms, and aging is increasingly recognized as a critical factor in understanding the mechanisms underlying tumorigenesis cancer progression. Aging well-established primary risk for while disruptions rhythms are intricately associated with progression of various tumors. Moreover, itself disrupts leading to physiological changes that may accelerate development. Despite these connections, specific interplay processes their collective impact on remains inadequately explored literature. In this review, we systematically explore influence We discuss how core genes tumor prognosis, highlighting shared hallmarks such genomic instability, cellular senescence, chronic inflammation. Furthermore, examine aging, focusing crosstalk contributes tumorigenesis, proliferation, apoptosis, well metabolism stability. By elucidating common pathways linking review provides new insights into pathophysiology identifies potential therapeutic strategies. propose targeting regulation could pave way novel treatments, including chronotherapy antiaging interventions, which offer important benefits clinical management cancer.
Language: Английский
Citations
2
Cellular Signalling, Journal Year: 2025, Volume and Issue: 127, P. 111605 - 111605
Published: Jan. 20, 2025
Language: Английский
Citations
1
Biomarker Research, Journal Year: 2025, Volume and Issue: 13(1)
Published: Jan. 23, 2025
Abstract Background Myelodysplastic neoplasms (MDS) are heterogeneous hematopoietic disorders characterized by ineffective hematopoiesis and genome instability. Mobilization of transposable elements (TEs) is an important source instability leading to oncogenesis, whereas small PIWI-interacting RNAs (piRNAs) act as cellular suppressors TEs. However, the roles TEs piRNAs in MDS remain unclear. Methods In this study, we examined TE piRNA expression through parallel RNA sequencing CD34+ stem cells from patients. Results Comparative analysis between control samples revealed several significantly dysregulated molecules. significant differences were observed lower-risk (LR-MDS) higher-risk (HR-MDS) samples. HR-MDS, found inverse correlation decreased levels increased these associated with patient outcomes. Importantly, upregulation PIWIL2 , which encodes a key factor pathway, independently predicted poor prognosis patients, underscoring its potential valuable disease marker. Furthermore, pathway data that dysregulation TE‒piRNA axis linked suppression processes related energy metabolism, cell cycle, immune response, suggesting disruptions affect activity. Conclusions Our findings demonstrate HR-MDS highlighting their role progression indicating level promising molecular marker for prognosis. Graphical
Language: Английский
Citations
1
Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2024, Volume and Issue: 253, P. 116543 - 116543
Published: Oct. 28, 2024
Language: Английский
Citations
5
Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 207 - 207
Published: Feb. 3, 2025
Breast cancer is the most common malignancy affecting women, manifesting as a heterogeneous disease with diverse molecular characteristics and clinical presentations. Recent studies have elucidated role of epigenetic modifications in pathogenesis breast cancer, including drug resistance efflux characteristics, offering potential new diagnostic prognostic markers, treatment efficacy predictors, therapeutic agents. Key include DNA cytosine methylation covalent modification histone proteins. Unlike genetic mutations, reprogramming landscape epigenome promising targeted therapy for reversal resistance. Epidrugs, which target modifications, can provide novel options by reversing acquired to treatment. Currently, approach involves combination therapies consisting epidrugs immune checkpoint inhibitors. This review examines aberrant regulation initiation progression, focusing on related estrogen signaling, resistance, epithelial–mesenchymal transition (EMT). It existing drugs treating agents that modify DNA, inhibitors acetyltransferases, deacetylases, methyltransferases, demethyltransferases. also delves into ongoing combining other addresses upcoming obstacles this field.
Language: Английский
Citations
0
Bioengineering, Journal Year: 2025, Volume and Issue: 12(4), P. 341 - 341
Published: March 26, 2025
Cancer treatment has historically depended on conventional methods like chemotherapy, radiation, and surgery; however, these strategies frequently present considerable limitations, including toxicity, resistance, negative impacts healthy tissues. In addressing challenges, drug-free cancer therapies have developed as viable alternatives, utilizing advanced physical biological to specifically target tumor cells while reducing damage normal This review examines several strategies, such high-intensity focused energy beams, nanosecond pulsed electric fields, photothermal therapy well the use of inorganic nanoparticles promote selective apoptosis. We also investigate significance targeting microenvironment, precision medicine, immunotherapy in progression personalized therapies. Although approaches demonstrate significant promise, challenges scalability, safety, regulatory obstacles must be resolved for clinical application. paper presents an overview current research therapies, emphasizing recent advancements, underlying scientific principles, steps required implementation.
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: April 4, 2025
Introduction: Gastric cancer (GC) exhibits high invasiveness, delayed diagnosis, and poor prognosis. Chronic atrophic gastritis (CAG), an initial stage within the Correa cascade, induces gastric mucosal inflammation atrophy, promoting genetic epigenetic alterations. MicroRNAs (miRNAs) dysregulation has been implicated in tumorigenesis, yet their specific roles CAG progression to GC remain unclear. Methods: Using clinical data from GEO database, we identified miRNAs differentially expressed mucosa serum samples patients. Murine models were established through administration of N-methyl-N-nitrosourea (MNU) high-salt diet (HSD). In vitro functional assays evaluated proliferation migration after miRNA modulation cell lines. MiRNA target validation involved luciferase reporter assays. Results: MiR-3613-5p expression was significantly elevated patients, tissues tumor tissues, human demonstrated increased miR-3613-5p following MNU HSD-induced CAG. Functionally, overexpression promoted vitro, whereas silencing alleviated pathological alterations (atrophy, hyperplasia, inflammatory infiltration) vivo. Mechanistically, inhibited Aquaporin 4 (AQP4) by directly targeting its 3'UTR. Discussion: Our findings provide first evidence that facilitates toward via negative regulation AQP4. These results highlight as a promising biomarker therapeutic target, suggesting antagomiR-3613-5p potential novel strategy prevent carcinogenesis.
Language: Английский
Citations
0
Medical Oncology, Journal Year: 2025, Volume and Issue: 42(5)
Published: April 9, 2025
Language: Английский
Citations
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: April 9, 2025
Language: Английский
Citations
0
Journal of Thrombosis and Thrombolysis, Journal Year: 2025, Volume and Issue: unknown
Published: April 21, 2025
Abstract miR-27a-3p targets several proteins on the coagulation cascade. The potential effect of direct oral anticoagulants (DOACs) treatment expression and their broader regulative anticoagulation is unknown. Fifty-nine atrial fibrillation patients treated with rivaroxaban ( n = 19), apixaban 27) or dabigatran 13), were included in study. was analyzed at baseline after 7 days DOAC therapy by using a predesigned TaqMan assay. Relative quantitation calculated compared pooled population different sample groups. did not alter (0.80 fold-change, p 0.486, population; 0.839 0.706, rivaroxaban; 0.921 0.800, apixaban; 0.733 0.540, dabigatran). differ between controls bleeding cases (0.833 0.588, baseline). Female had trend towards increased (1.564 0.177) reduced (0.683 0.243) to male patients. Despite regulatory role cascade, DOACs its expression. However, additional studies ethnic groups are necessary fully elucidate effect, if any, Graphical
Language: Английский
Citations
0