Cancers,
Год журнала:
2024,
Номер
16(14), С. 2580 - 2580
Опубликована: Июль 18, 2024
Curcumin,
a
polyphenolic
compound
derived
from
Curcuma
longa,
exhibits
significant
therapeutic
potential
in
cancer
management.
This
review
explores
curcumin’s
mechanisms
of
action,
the
challenges
related
to
its
bioavailability,
and
enhancement
through
modern
technology
approaches.
Curcumin
demonstrates
strong
antioxidant
anti-inflammatory
properties,
contributing
ability
neutralize
free
radicals
inhibit
inflammatory
mediators.
Its
anticancer
effects
are
mediated
by
inducing
apoptosis,
inhibiting
cell
proliferation,
interfering
with
tumor
growth
pathways
various
colon,
pancreatic,
breast
cancers.
However,
clinical
application
is
limited
poor
bioavailability
due
rapid
metabolism
low
absorption.
Novel
delivery
systems,
such
as
curcumin-loaded
hydrogels
nanoparticles,
have
shown
promise
improving
curcumin
efficacy.
Additionally,
photodynamic
therapy
has
emerged
complementary
approach,
where
light
exposure
enhances
modulating
molecular
crucial
for
survival.
Studies
highlight
that
combining
concentrations
visible
irradiation
significantly
boosts
antitumor
efficacy
compared
alone.
The
interaction
cytochromes
or
drug
transporters
may
play
role
altering
pharmacokinetics
conventional
medications,
which
necessitates
careful
consideration
settings.
Future
research
should
focus
on
optimizing
understanding
fully
harness
treatment.
Pharmaceutics,
Год журнала:
2023,
Номер
15(2), С. 639 - 639
Опубликована: Фев. 14, 2023
Cancer
continues
to
cause
an
alarming
number
of
deaths
globally,
and
its
burden
on
the
health
system
is
significant.
Though
different
conventional
therapeutic
procedures
are
exploited
for
cancer
treatment,
prevalence
death
rates
remain
elevated.
These,
therefore,
insinuate
that
novel
more
efficient
treatment
needed
cancer.
Curcumin,
a
bioactive,
natural,
phenolic
compound
isolated
from
rhizome
herbaceous
plant
turmeric,
receiving
great
interest
exciting
broad
pharmacological
properties.
Curcumin
presents
anticancer
capacities
can
be
utilized
as
photosensitizing
drug
in
photodynamic
therapy
(PDT).
Nonetheless,
curcumin′s
poor
bioavailability
related
pharmacokinetics
limit
clinical
utility
treatment.
This
review
looks
at
physical
chemical
properties,
bioavailability,
safety
curcumin,
while
focusing
curcumin
agent
photosensitizer
PDT.
The
possible
mechanisms
cellular
targets
PDT
highlighted.
Furthermore,
recent
improvements
curcumin’s
using
nanoformulations
delivery
systems
presented.
Nanomaterials,
Год журнала:
2024,
Номер
14(8), С. 672 - 672
Опубликована: Апрель 12, 2024
Curcumin,
an
organic
phenolic
molecule
that
is
extracted
from
the
rhizomes
of
Curcuma
longa
Linn,
has
undergone
extensive
evaluation
for
its
diverse
biological
activities
in
both
animals
and
humans.
Despite
favorable
characteristics,
curcumin
encounters
various
formulation
challenges
stability
issues
can
be
effectively
addressed
through
application
nanotechnology.
Nano-based
techniques
specifically
focused
on
enhancing
solubility,
bioavailability,
therapeutic
efficacy
while
mitigating
toxicity,
have
been
explored
curcumin.
This
review
systematically
presents
information
improvement
curcumin’s
beneficial
properties
when
incorporated,
either
individually
or
conjunction
with
other
drugs,
into
nanosystems
such
as
liposomes,
nanoemulsions,
polymeric
micelles,
dendrimers,
nanoparticles,
solid-lipid
nanostructured
lipid
carriers.
Additionally,
examines
ongoing
clinical
trials
recently
granted
patents,
offering
a
thorough
overview
dynamic
landscape
delivery.
Researchers
are
currently
exploring
nanocarriers
crucial
features
surface
modification,
substantial
loading
capacity,
biodegradability,
compatibility,
autonomous
targeting
specificity
selectivity.
Nevertheless,
utilization
delivery
still
initial
phases,
regulatory
approval
pending
persistent
safety
concerns
surrounding
their
use.
ACS Sustainable Chemistry & Engineering,
Год журнала:
2024,
Номер
12(3), С. 1207 - 1220
Опубликована: Янв. 10, 2024
Photoactivated
pesticides
(PPs)
have
photodynamic
antimicrobial
activities
and
show
good
environmental
compatibility
slow
resistance
development.
However,
the
disadvantages
of
easy
aggregation,
short
duration,
low
efficiency
seriously
restrict
efficient
application
PPs.
Hollow
mesoporous
copper
sulfide
nanoparticles
(HMCuS
NPs)
with
unique
optical
properties
activity
under
light
irradiation,
which
are
considered
smart
drug
delivery
carriers
due
to
their
water
dispersivity
high
encapsulation
surface
area.
Herein,
novel
acid-responsive
photoactivated
pesticide
nanocapsules
(PPs@HMCuS-CTS
were
established
by
electrostatically
coating
HMCuS
NPs
loaded
PPs
(curcumin
physcion)
chitosan
(CTS).
The
results
showed
that
obtained
had
desirable
(PDI0.25)
release
properties.
PPs@HMCuS-CTS
irradiation
was
more
than
1.47
times
those
alone
mixture
synergistic
activity.
Rainfastness,
safety
assessment,
genotoxicity
evaluation
demonstrated
deposited
1.28
on
plant
foliage
without
any
damage
crop.
Therefore,
based
potential
be
an
safe
system.
LWT,
Год журнала:
2021,
Номер
153, С. 112480 - 112480
Опубликована: Сен. 17, 2021
The
use
of
curcumin
in
the
food
industry
is
constrained
by
its
poor
aqueous
dispersibility
and
instability.
Previous
studies
have
shown
that
stable
nanoparticles
can
be
prepared
using
a
pH-driven
method.
In
this
study,
nanoencapsulation
soybean
protein
isolate
(SPI)
was
achieved
effect
final
pH
on
SPI
SPI-curcumin
(SPI-Cur)
nanocomposites
determined
analyzing
encapsulation
efficiency
stability.
had
high
for
stable,
especially
at
7
8.
formation
mechanisms
SPI-Cur
were
further
molecular
docking
multispectral
analyses.
results
showed
hydrogen
bond
acceptors
(O−)
under
alkaline
media
interacted
with
donor
groups
(N–H)
amino
acids
to
form
bonds.
Throughout
process,
hydrophobic
interactions
promoted
nanocomposites,
strong
static
fluorescence
quenching
SPI.
Furthermore,
CD
spectroscopy
demonstrated
method
altered
secondary
structure
This
study
provides
evidence
interaction
mechanism
between
different
stages
indicates
used
as
delivery
system
nutraceuticals.
Bioactive Materials,
Год журнала:
2022,
Номер
24, С. 1 - 19
Опубликована: Дек. 9, 2022
Smart
biomaterials
can
sense
and
react
to
physiological
or
external
environmental
stimuli
(e.g.,
mechanical,
chemical,
electrical,
magnetic
signals).
The
last
decades
have
seen
exponential
growth
in
the
use
development
of
smart
dental
for
antimicrobial
applications
dentistry.
These
biomaterial
systems
offer
improved
efficacy
controllable
bio-functionalities
prevent
infections
extend
longevity
devices.
This
review
article
presents
current
state-of-the-art
design,
evaluation,
advantages,
limitations
bioactive
stimuli-responsive
autonomous
materials
applications.
First,
importance
classification
are
discussed.
Second,
categories
bioresponsive
antibacterial
systematically
itemized
based
on
different
stimuli,
including
pH,
enzymes,
light,
field,
vibrations.
For
each
category,
their
mechanism,
applications,
examples
Finally,
we
examined
obstacles
required
develop
clinically
relevant
these
appealing
technologies.
