Psilocybin therapy for females with anorexia nervosa: a phase 1, open-label feasibility study

Nature Medicine, Год журнала: 2023, Номер 29(8), С. 1947 - 1953

Опубликована: Июль 24, 2023

Abstract Anorexia nervosa (AN) is a deadly illness with no proven treatments to reverse core symptoms and medications approved by the US Food Drug Administration. Novel are urgently needed improve clinical outcomes. In this open-label feasibility study, 10 adult female participants (mean body mass index 19.7 kg m − 2 ; s.d. 3.7) who met Diagnostic Statistical Manual of Mental Disorders , Fifth Edition (DSM-5) criteria for AN or pAN (partial remission) were recruited study conducted at an academic research institute. Participants received single 25-mg dose synthetic psilocybin in conjunction psychological support. The primary aim was assess safety, tolerability post-treatment incidences occurrences adverse events (AEs) clinically significant changes electrocardiogram (ECG), laboratory tests, vital signs suicidality. No observed ECG, Two developed asymptomatic hypoglycemia post-treatment, which resolved within 24 h. other values. All AEs mild transient nature. Participants’ qualitative perceptions suggest that treatment acceptable most participants. Results therapy safe, tolerable AN, promising finding given physiological dangers problems engagement. ClinicalTrials.gov identifier NCT04661514 .

Язык: Английский

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Efficacy and safety of psychedelics for the treatment of mental disorders: A systematic review and meta-analysis

Psychiatry Research, Год журнала: 2024, Номер 335, С. 115886 - 115886

Опубликована: Март 28, 2024

Язык: Английский

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Posttraumatic stress disorder, traumatic events, and longitudinal eating disorder treatment outcomes: A systematic review

International Journal of Eating Disorders, Год журнала: 2023, Номер 56(6), С. 1055 - 1074

Опубликована: Март 14, 2023

Many individuals diagnosed with an eating disorder (ED) have been exposed to traumatic events, and some of these are posttraumatic stress (PTSD). Although theorized by researchers clinicians, it is unclear whether event exposure or PTSD interferes outcomes from ED treatment. The objective the current study was systematically review literature on events and/or as either predictors moderators psychological treatment in EDs.

Язык: Английский

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Educational moderation of gender disparities in psychedelic health outcomes

Опубликована: Март 6, 2025

While public interest in psychedelics is rising due to their potential effects on mental health, evidence suggests that these associations vary across demographic groups. Notably, prior research indicates women may experience different outcomes from psychedelic use compared men. Given highly educated tend have superior health general, this study examines whether education modifies the association between Lifetime Classic Psychedelic Use (LCPU) and psychological distress. Using pooled data National Survey of Drug Health (NSDUH) (2008–2019) (n = 458,372), applies nested Ordinary Least Square Regression (OLS) regression models Stata 18. Results three-way interaction terms indicate while LCPU associated with higher distress overall, varies levels. This pattern rather than universally improving depend key social factors such as gender.

Язык: Английский

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The integrated treatment of eating disorders, posttraumatic stress disorder, and psychiatric comorbidity: a commentary on the evolution of principles and guidelines

Frontiers in Psychiatry, Год журнала: 2023, Номер 14

Опубликована: Май 12, 2023

Psychiatric comorbidity is the norm in assessment and treatment of eating disorders (EDs), traumatic events lifetime PTSD are often major drivers these challenging complexities. Given that trauma, PTSD, psychiatric significantly influence ED outcomes, it imperative problems be appropriately addressed practice guidelines. The presence associated noted some but not all sets existing guidelines, they mostly do little to address problem other than referring independent guidelines for disorders. This disconnect perpetuates a “silo effect,” which each set complexity comorbidities. Although there several published EDs, likewise, none them specifically + PTSD. result lack integration between providers, leads fragmented, incomplete, uncoordinated ineffective care severely ill patients with situation can inadvertently promote chronicity multimorbidity may particularly relevant treated higher levels care, where prevalence rates concurrent reach as high 50% many more having subthreshold has been progress recognition recommendations treating this common remain undeveloped, when co-occurring disorders, such mood, anxiety, dissociative, substance use, impulse control, obsessive–compulsive, attention-deficit hyperactivity, personality also trauma-related. In commentary, assessing related critically reviewed. An integrated principles used planning trauma-related recommended context intensive therapy. These strategies borrowed from evidence-based approaches. Evidence suggests continuing traditional single-disorder focused, sequential models prioritize integrated, trauma-focused approaches short-sighted perpetuate dangerous multimorbidity. Future would well illness depth.

Язык: Английский

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Eating disorder patients with and without PTSD treated in residential care: discharge and 6-month follow-up results

Journal of Eating Disorders, Год журнала: 2023, Номер 11(1)

Опубликована: Март 27, 2023

We studied whether provisional posttraumatic stress disorder (PTSD) moderated discharge (DC) and 6-month follow-up (FU) outcomes of multi-modal, integrated eating (ED) residential treatment (RT) based upon principles cognitive processing therapy (CPT).ED patients [N = 609; 96% female; mean age (± SD) 26.0 ± 8.8 years; 22% LGBTQ +] with without PTSD completed validated assessments at admission (ADM), DC FU to measure severity ED, PTSD, major depressive (MDD), state-trait anxiety (STA) symptoms, quality life (EDQOL). tested the course symptom change using mixed models analyses if ED diagnosis, ADM BMI, onset + orientation were significant covariates change. Number days between was used as a weighting measure.Despite sustained improvements RT in total group, group had significantly higher scores on all measures time points (p ≤ .001). Patients (n 261) 348) showed similar from remained statistically improved compared ADM. The only worsening observed MDD yet lower than There no by interactions for any measures. Age covariate EDI-2, PHQ-9, STAI-T, EDQOL such that an earlier associated worse outcome. BMI also EDE-Q, models, outcome.Integrated approaches address comorbidity can be successfully delivered are FU. Improving strategies prevent post-DC recurrence symptoms is important challenging area future work.Posttraumatic common disorders outcomes. However, this has not been extensively admitted levels care, treatment. Using clinical approach (CPT) other evidence-based treatments, we 6 months following 609 [96% PTSD. All admission. measured including those disorder, depression, state trait anxiety, life, every point (admission, discharge, follow-up). depression follow-up. In conclusion, related problems discharge. post-discharge work.

Язык: Английский

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Psychedelics in the treatment of eating disorders: Rationale and potential mechanisms

European Neuropsychopharmacology, Год журнала: 2023, Номер 75, С. 1 - 14

Опубликована: Июнь 21, 2023

Eating disorders are serious illnesses showing high rates of mortality and comorbidity with other mental health problems. Psychedelic-assisted therapy has recently shown potential in the treatment several common comorbidities eating disorders, including mood post-traumatic stress disorder, substance use disorders. The theorized therapeutic mechanisms psychedelic-assisted suggest that it could be beneficial as well. In this review, we summarize preliminary data on efficacy people anorexia nervosa, bulimia binge which include studies case reports ketamine, MDMA, psilocybin, ayahuasca. We then discuss these three both general those relatively specific to find evidence may effective nervosa very little available disorder. Regarding mechanisms, able improve beliefs about body image, normalize reward processing, promote cognitive flexibility, facilitate trauma processing. Just importantly, appears factors relevant many their comorbidities. Lastly, safety concerns associated treatments present recommendations for future research.

Язык: Английский

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Minorities’ diminished psychedelic returns

Drug Science Policy and Law, Год журнала: 2023, Номер 9

Опубликована: Янв. 1, 2023

Although there is a growing support for the use of psychedelics to improve health marginalized groups, are some critical gaps. First, no empirical studies have examined effects on Black Americans. Second, little research population psychedelics. Third, has tested how cultural set and setting may affect relationship between health. Specifically, could economic inequality or criminal justice system jeopardize people. This study tests race gender differences in multiple aspects lifetime classic psychedelic use, specifically drug arrest history, inequality, psychological distress. project uses pooled data White respondents from National Survey Drug Use Health (2008–2019) ( N = 490,586). The analysis includes series logistic ordinary least square regression models conducted Stata 17. Results demonstrate that people policed more even though they less drugs than Whites. Higher class men likely psychedelics, while does not predict among Finally, women, positive association enhanced by class, negative effect history buffered However, do gain benefits regardless history. suggest systemic deters eliminates all

Язык: Английский

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Minorities’ diminished psychedelic returns: Cardio-metabolic health

Drug Science Policy and Law, Год журнала: 2024, Номер 10

Опубликована: Янв. 1, 2024

Although there is a growing support for the protective factor of psychedelics to improve mental and physical health, these effects may differ across racial ethnic groups. Race differences remain critically understudied gap in psychedelic literature. Recent empirical research into Minority Diminished Psychedelic Returns suggests that Black Americans gain little health benefits from use. This study tests race association between Lifetime Classic Use multiple indicators cardio-metabolic including cardiovascular disease, hypertension, Body Mass Index. project uses pooled data White adults respondents National Survey Drug Health (NSDUH) (2005 2019) (N = 421,477). The analysis includes series logistic ordinary least square regression models conducted Stata 18. Results demonstrate associated with better health. However, by find no LCPU cardio metabolic people, while positive associations significant white people. Overall, results lend MPDR theory.

Язык: Английский

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Diminished psychedelic returns on distress: Marital status and household size

PLoS ONE, Год журнала: 2024, Номер 19(3), С. e0293675 - e0293675

Опубликована: Март 7, 2024

Although the use of psychedelics to impact health has seen growth, little research tested effects culture conditions on relationship. More specifically, how does marital status and family size affect relationship between health? This study tests Lifetime Classic Psychedelic Use (LCPU), status, household (number people living in a household) levels psychological distress past 30 days. project uses pooled data from National Survey Drug Health (NSDUH) (2010 2018) ( N = 674,521). The Final sample is determined by dependent variable, month (n 158,633). analysis includes series nested logistic regression models conducted Stata 17. Results indicate that LCPU independently associated with better health, but association varies across size. Larger households are higher distress, which then exacerbated among users. Furthermore, three-way interactions reveal negative gets larger psychedelic users who married, divorced, widowed. Overall, results suggest negatively impacts those widowed experiencing worst outcomes.

Язык: Английский

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