Psilocybin therapy for females with anorexia nervosa: a phase 1, open-label feasibility study

Nature Medicine, Journal Year: 2023, Volume and Issue: 29(8), P. 1947 - 1953

Published: July 24, 2023

Abstract Anorexia nervosa (AN) is a deadly illness with no proven treatments to reverse core symptoms and medications approved by the US Food Drug Administration. Novel are urgently needed improve clinical outcomes. In this open-label feasibility study, 10 adult female participants (mean body mass index 19.7 kg m − 2 ; s.d. 3.7) who met Diagnostic Statistical Manual of Mental Disorders , Fifth Edition (DSM-5) criteria for AN or pAN (partial remission) were recruited study conducted at an academic research institute. Participants received single 25-mg dose synthetic psilocybin in conjunction psychological support. The primary aim was assess safety, tolerability post-treatment incidences occurrences adverse events (AEs) clinically significant changes electrocardiogram (ECG), laboratory tests, vital signs suicidality. No observed ECG, Two developed asymptomatic hypoglycemia post-treatment, which resolved within 24 h. other values. All AEs mild transient nature. Participants’ qualitative perceptions suggest that treatment acceptable most participants. Results therapy safe, tolerable AN, promising finding given physiological dangers problems engagement. ClinicalTrials.gov identifier NCT04661514 .

Language: Английский

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Efficacy and safety of psychedelics for the treatment of mental disorders: A systematic review and meta-analysis

Psychiatry Research, Journal Year: 2024, Volume and Issue: 335, P. 115886 - 115886

Published: March 28, 2024

Language: Английский

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Posttraumatic stress disorder, traumatic events, and longitudinal eating disorder treatment outcomes: A systematic review

International Journal of Eating Disorders, Journal Year: 2023, Volume and Issue: 56(6), P. 1055 - 1074

Published: March 14, 2023

Many individuals diagnosed with an eating disorder (ED) have been exposed to traumatic events, and some of these are posttraumatic stress (PTSD). Although theorized by researchers clinicians, it is unclear whether event exposure or PTSD interferes outcomes from ED treatment. The objective the current study was systematically review literature on events and/or as either predictors moderators psychological treatment in EDs.

Language: Английский

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Eating disorder patients with and without PTSD treated in residential care: discharge and 6-month follow-up results

Journal of Eating Disorders, Journal Year: 2023, Volume and Issue: 11(1)

Published: March 27, 2023

We studied whether provisional posttraumatic stress disorder (PTSD) moderated discharge (DC) and 6-month follow-up (FU) outcomes of multi-modal, integrated eating (ED) residential treatment (RT) based upon principles cognitive processing therapy (CPT).ED patients [N = 609; 96% female; mean age (± SD) 26.0 ± 8.8 years; 22% LGBTQ +] with without PTSD completed validated assessments at admission (ADM), DC FU to measure severity ED, PTSD, major depressive (MDD), state-trait anxiety (STA) symptoms, quality life (EDQOL). tested the course symptom change using mixed models analyses if ED diagnosis, ADM BMI, onset + orientation were significant covariates change. Number days between was used as a weighting measure.Despite sustained improvements RT in total group, group had significantly higher scores on all measures time points (p ≤ .001). Patients (n 261) 348) showed similar from remained statistically improved compared ADM. The only worsening observed MDD yet lower than There no by interactions for any measures. Age covariate EDI-2, PHQ-9, STAI-T, EDQOL such that an earlier associated worse outcome. BMI also EDE-Q, models, outcome.Integrated approaches address comorbidity can be successfully delivered are FU. Improving strategies prevent post-DC recurrence symptoms is important challenging area future work.Posttraumatic common disorders outcomes. However, this has not been extensively admitted levels care, treatment. Using clinical approach (CPT) other evidence-based treatments, we 6 months following 609 [96% PTSD. All admission. measured including those disorder, depression, state trait anxiety, life, every point (admission, discharge, follow-up). depression follow-up. In conclusion, related problems discharge. post-discharge work.

Language: Английский

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The integrated treatment of eating disorders, posttraumatic stress disorder, and psychiatric comorbidity: a commentary on the evolution of principles and guidelines

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: May 12, 2023

Psychiatric comorbidity is the norm in assessment and treatment of eating disorders (EDs), traumatic events lifetime PTSD are often major drivers these challenging complexities. Given that trauma, PTSD, psychiatric significantly influence ED outcomes, it imperative problems be appropriately addressed practice guidelines. The presence associated noted some but not all sets existing guidelines, they mostly do little to address problem other than referring independent guidelines for disorders. This disconnect perpetuates a “silo effect,” which each set complexity comorbidities. Although there several published EDs, likewise, none them specifically + PTSD. result lack integration between providers, leads fragmented, incomplete, uncoordinated ineffective care severely ill patients with situation can inadvertently promote chronicity multimorbidity may particularly relevant treated higher levels care, where prevalence rates concurrent reach as high 50% many more having subthreshold has been progress recognition recommendations treating this common remain undeveloped, when co-occurring disorders, such mood, anxiety, dissociative, substance use, impulse control, obsessive–compulsive, attention-deficit hyperactivity, personality also trauma-related. In commentary, assessing related critically reviewed. An integrated principles used planning trauma-related recommended context intensive therapy. These strategies borrowed from evidence-based approaches. Evidence suggests continuing traditional single-disorder focused, sequential models prioritize integrated, trauma-focused approaches short-sighted perpetuate dangerous multimorbidity. Future would well illness depth.

Language: Английский

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Psychedelics in the treatment of eating disorders: Rationale and potential mechanisms

European Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 75, P. 1 - 14

Published: June 21, 2023

Eating disorders are serious illnesses showing high rates of mortality and comorbidity with other mental health problems. Psychedelic-assisted therapy has recently shown potential in the treatment several common comorbidities eating disorders, including mood post-traumatic stress disorder, substance use disorders. The theorized therapeutic mechanisms psychedelic-assisted suggest that it could be beneficial as well. In this review, we summarize preliminary data on efficacy people anorexia nervosa, bulimia binge which include studies case reports ketamine, MDMA, psilocybin, ayahuasca. We then discuss these three both general those relatively specific to find evidence may effective nervosa very little available disorder. Regarding mechanisms, able improve beliefs about body image, normalize reward processing, promote cognitive flexibility, facilitate trauma processing. Just importantly, appears factors relevant many their comorbidities. Lastly, safety concerns associated treatments present recommendations for future research.

Language: Английский

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Minorities’ diminished psychedelic returns

Drug Science Policy and Law, Journal Year: 2023, Volume and Issue: 9

Published: Jan. 1, 2023

Although there is a growing support for the use of psychedelics to improve health marginalized groups, are some critical gaps. First, no empirical studies have examined effects on Black Americans. Second, little research population psychedelics. Third, has tested how cultural set and setting may affect relationship between health. Specifically, could economic inequality or criminal justice system jeopardize people. This study tests race gender differences in multiple aspects lifetime classic psychedelic use, specifically drug arrest history, inequality, psychological distress. project uses pooled data White respondents from National Survey Drug Use Health (2008–2019) ( N = 490,586). The analysis includes series logistic ordinary least square regression models conducted Stata 17. Results demonstrate that people policed more even though they less drugs than Whites. Higher class men likely psychedelics, while does not predict among Finally, women, positive association enhanced by class, negative effect history buffered However, do gain benefits regardless history. suggest systemic deters eliminates all

Language: Английский

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Minorities’ diminished psychedelic returns: Cardio-metabolic health

Drug Science Policy and Law, Journal Year: 2024, Volume and Issue: 10

Published: Jan. 1, 2024

Although there is a growing support for the protective factor of psychedelics to improve mental and physical health, these effects may differ across racial ethnic groups. Race differences remain critically understudied gap in psychedelic literature. Recent empirical research into Minority Diminished Psychedelic Returns suggests that Black Americans gain little health benefits from use. This study tests race association between Lifetime Classic Use multiple indicators cardio-metabolic including cardiovascular disease, hypertension, Body Mass Index. project uses pooled data White adults respondents National Survey Drug Health (NSDUH) (2005 2019) (N = 421,477). The analysis includes series logistic ordinary least square regression models conducted Stata 18. Results demonstrate associated with better health. However, by find no LCPU cardio metabolic people, while positive associations significant white people. Overall, results lend MPDR theory.

Language: Английский

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Diminished psychedelic returns on distress: Marital status and household size

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(3), P. e0293675 - e0293675

Published: March 7, 2024

Although the use of psychedelics to impact health has seen growth, little research tested effects culture conditions on relationship. More specifically, how does marital status and family size affect relationship between health? This study tests Lifetime Classic Psychedelic Use (LCPU), status, household (number people living in a household) levels psychological distress past 30 days. project uses pooled data from National Survey Drug Health (NSDUH) (2010 2018) ( N = 674,521). The Final sample is determined by dependent variable, month (n 158,633). analysis includes series nested logistic regression models conducted Stata 17. Results indicate that LCPU independently associated with better health, but association varies across size. Larger households are higher distress, which then exacerbated among users. Furthermore, three-way interactions reveal negative gets larger psychedelic users who married, divorced, widowed. Overall, results suggest negatively impacts those widowed experiencing worst outcomes.

Language: Английский

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Minorities’ Diminished Psychedelic Returns: Income and Educations Impact on Whites, Blacks, Hispanics, and Asians

Journal of Racial and Ethnic Health Disparities, Journal Year: 2024, Volume and Issue: unknown

Published: May 16, 2024

Abstract Growing evidence suggests that the race and ethnic minority population may experience fewer protective effects of psychedelics on mental health. The diminished psychedelic returns theory proposes racism, manifested in socioeconomic inequality, could partially account for smaller health gains observed. Therefore, it is important to investigate whether inequality reduces impact outcomes populations. Additionally, despite having higher status, remains unclear use among minorities associated with same level benefits as observed non-Hispanic whites. This study utilizes data from National Survey Drug Use ( N = 2008 2019), which involved 458,372 participants aged 18 above. objective examine various (MDMA, psilocybin, DMT, ayahuasca, peyote/mescaline, LSD), well lifetime classic (LCPU), psychological distress past month, taking into factors (education family income) race/ethnic differences (White, Black, Hispanic, Asian). analysis employed a series nested ordinary least-square regression models using Stata 18. results indicate that, after controlling there no association between Black Hispanic distress. However, white lower levels education income, groups does not appear be linked reduced stress. In fact, Asians certain increased

Language: Английский

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