Cited by The Relation Between Vitamin D and Traumatic Brain Injury: Possible Mechanisms and Effect on the Severity and Progression

Effect of Regular Aerobic Exercise on Cognitive Function, Depression Level and Regulative Role of Neurotrophic Factor: A Prospective Cohort Study in the Young and the Middle-Aged Sample DOI

Lingming Kong,

Liqin Miu,

Yao Wen-wei

и другие.

Risk Management and Healthcare Policy, Год журнала: 2024, Номер Volume 17, С. 935 - 943

Опубликована: Апрель 1, 2024

Mild cognitive impairment (MCI) and depressive disorder (DD), which are associated with unhealthy lifestyles, prevalent worldwide. This study aimed to investigate the effects of regular aerobic exercise on function, depression, regulatory role neurotrophic growth factors for providing scientific basis in preventing MCI DD healthy individuals. Eighty members fitness center 80 community residents were recruited, who administered by Repeatable Battery Assessment Neuropsychological Status (RBANS) Patient Health Questionnaire (PHQ-9). Brain-derived factor (BDNF) glial cell-line-derived (GDNF) peripheral blood detected enzyme-linked immunosorbent assay (ELISA). The RBANS other scores, except visuospatial abilities, higher PHQ-9 scores lower group than control group. concentrations BDNF GDNF those its positively negatively correlated levels. Finally, multiple regression analysis showed that BDNF, as a predictor RBANS, could explain 59.90% variance was 12.30% variance. Regular can improve function symptoms increasing

Язык: Английский

Процитировано

Ginsenoside Re Prevents Depression-like Behaviors via Inhibition of Inflammation, Oxidative Stress, and Activating BDNF/TrkB/ERK/CREB Signaling: An In Vivo and In Vitro Study DOI

Hongyu Chen,

Mengmeng Dong,

Huihan He

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(36), С. 19838 - 19851

Опубликована: Авг. 26, 2024

Depression is a widespread disease, with high mortality and recurrence rates. Recent studies have shown that elevated cytokine levels are implicated in the molecular mechanisms of depression. Oxidative stress contributes to stimulation production. Growing evidence suggests ginsenoside Re (Gs-Re) exerts neuroprotective effect on hippocampus by suppressing oxidative inflammation. However, mechanism Gs-Re treatment depression remain understudied. This study aimed evaluate antidepressant-like effects possible underlying mechanisms. In this article, was studied both vitro (H

Язык: Английский

Процитировано

Struggling Can Also Show on the Inside: Current Knowledge of the Impact of Childhood Maltreatment on Biomarkers in Mood Disorderss DOI

Maj Vinberg, Roger S. McIntyre, Annamaria Giraldi

и другие.

Neuropsychiatric Disease and Treatment, Год журнала: 2024, Номер Volume 20, С. 583 - 595

Опубликована: Март 1, 2024

Abstract: The link between childhood maltreatment and mood disorders is complex involves multiple bio-psycho-social factors that affect molecular pathways. present narrative review aims to clarify the current understanding of impact on biomarkers in patients with their first-degree relatives. Neurotransmitters, such as serotonin, dopamine, norepinephrine, hormones (eg stress hormone cortisol), play a crucial role regulating emotion. Childhood can alter levels functioning these neurotransmitters brain; further, lead structural connectivity changes brain, hence contributing development moderating illness presentation modifying response treatments. information, therefore, appears mandatory treatment planning critical factor therapeutic algorithms. Further research needed fully understand pathways develop new modalities for individuals who have experienced effective preventive interventions at risk developing disorders. Keywords: biomarkers, maltreatment, disorders, biosignatures, biotype

Язык: Английский

Процитировано

Effects and safety of Ginkgo biloba on depression: a systematic review and meta-analysis DOI

Jingya Lin,

Xiaojing Sun,

Lingli Yang

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Март 18, 2024

Background: Because depression is a major factor contributing to the global disease burden, we tried analyze effects and safety of Ginkgo biloba (GKB) on patients with depression. Methods: We conducted literature search for articles published between January 2002 May 2022 in seven online databases (PubMed, Scopus, Embase, Google Scholar, Web Sciences, Cochrane Library, China National Knowledge Infrastructure). A systematic review meta-analysis were performed compare GKB depression, including subjective objective indicators evaluation. Results: In total, 21 eligible nine among 2074 included. Several outcomes showed difference, group had better results than control group, Hamilton Depression Scale (HAMD), after taking 4 weeks (MD = −2.86, 95%CI [−4.27, −1.46], p < 0.01), 6 (mean difference (MD) −3.36, [−4.05, −2.67], 8 −4.58, 95% CI [−6.11, −3.05], modified Barthel index (MBI) 14.86, [12.07, 17.64], Edinburgh-Scandinavian stroke scale (MESSS) −4.57, [−6.34, −2.79], brain-derived neurotrophic (BDNF) 16.35, [7.34, 25.36], 5-hydroxytryptamine (5-HT) 4.57, [3.08, 6.05], clinical efficacy (risk ratio, RR 1.24, [1.17, 1.32], 0.01). However, there no differences adverse events controls. Conclusion: conclusion, main finding was that treated MBI, MESSS, BDNF, 5-HT, HAMD values weeks, group. might reduce risk or depressive symptoms safe efficacy. Systematic Review Registration: identifier (INPLASY2023100052)

Язык: Английский

Процитировано

The Relation Between Vitamin D and Traumatic Brain Injury: Possible Mechanisms and Effect on the Severity and Progression DOI

Nada Ibrahim Hendi, M. Ben Khaled, Nour Shaheen

и другие.

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано