Journal of Functional Foods, Год журнала: 2024, Номер 124, С. 106650 - 106650
Опубликована: Дек. 26, 2024
Язык: Английский
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160719 - 160719
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
Biomolecules, Год журнала: 2025, Номер 15(4), С. 502 - 502
Опубликована: Март 30, 2025
Depression is a multifactorial psychiatric condition with complex pathophysiology, increasingly linked to neuroinflammatory processes. The present review explores the role of neuroinflammation in depression, focusing on glial cell activation, cytokine signaling, blood-brain barrier dysfunction, and disruptions neurotransmitter systems. article highlights how inflammatory mediators influence brain regions implicated mood regulation, such as hippocampus, amygdala, prefrontal cortex. further discusses involvement hypothalamic-pituitary-adrenal (HPA) axis, oxidative stress, kynurenine pathway, providing mechanistic insights into chronic inflammation may underlie emotional cognitive symptoms depression. bidirectional relationship between depressive emphasized, along peripheral immune responses systemic stress. By integrating molecular, cellular, neuroendocrine perspectives, this supports growing field immunopsychiatry lays foundation for novel diagnostic biomarkers anti-inflammatory treatment approaches Further research holds promise developing more effective personalized interventions individuals suffering from
Язык: Английский
Процитировано
1
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Апрель 29, 2025
Ginsenoside Re (Re) was proved effective in improving depressive-like behaviors. However, the potential antidepressant mechanism of remains unrevealed. In this study, we investigated whether PINK1-mediated mitophagy and NLRP3 inflammasomes were linked to chronic unpredictable mild stress (CUMS) mice lipopolysaccharide (LPS)-stimulated astrocytes. RNA sequencing bioinformatics analyses performed discover targets pathways associated with Re. PTEN-induced putative kinase 1 (PINK1) knockdown conducted clarify role The outcomes showed that ameliorated behaviors, activated mitophagy, inhibited inflammasome activation. PINK1 attenuated effect promotion decline activation caused by reversed knockdown. conclusion, promoting exert its effect.
Язык: Английский
Процитировано
0
Frontiers in Chemistry, Год журнала: 2025, Номер 13
Опубликована: Май 30, 2025
Depression is a psychological disorder with significant global impact. It widely hypothesized that this associated neuroinflammation, which disrupts neural homeostasis through various pathways. This study aims to investigate the effective compounds and mechanisms of Black Ginseng under forest (BG) in combating neuroinflammation. Utilizing methods such as UPLC-QE Orbitrap-MS, network pharmacology, molecular docking, cell biology, efficacy BG was demonstrated, its active components were identified. Cell viability apoptosis assessed using Trans well migration assays flow cytometry. The mRNA expression target genes confirmed real-time quantitative PCR (RT-qPCR), elucidating anti-neuroinflammatory mechanism. results indicated exhibited more pronounced effect on ameliorating neuroinflammatory conditions compared (FG). main found research development, including Ginsenoside F1, Rk1, Rg3, etc. Among these, F1 emerged most potent component for treating evidenced by reduced apoptosis. demonstrates can modulate PI3K-Akt signaling pathway, leading reduction levels AKT1, MAPK1, PIK3CA, EGFR, other mRNAs. These findings suggest promising natural antidepressant, providing both theoretical experimental foundations development new antidepressants based components.
Язык: Английский
Процитировано
0
Journal of Functional Foods, Год журнала: 2024, Номер 124, С. 106650 - 106650
Опубликована: Дек. 26, 2024
Язык: Английский
Процитировано
0