Transcranial alternating current stimulation for neuropsychiatric disorders: a systematic review of treatment parameters and outcomes DOI Creative Commons

Fatemeh Gholamali Nezhad,

Josh Martin, Vanessa K. Tassone

и другие.

Frontiers in Psychiatry, Год журнала: 2024, Номер 15

Опубликована: Авг. 14, 2024

Background Transcranial alternating current stimulation (tACS) alters cortical excitability with low-intensity and thereby modulates aberrant brain oscillations. Despite the recent increase in studies investigating feasibility efficacy of tACS treating neuropsychiatric disorders, its mechanisms, as well optimal parameters, are not fully understood. Objectives This systematic review aimed to compile human research on for disorders delineate typical treatment parameters these conditions evaluate outcomes. Methods A search published unpublished registered clinical trials was conducted through OVID (MEDLINE, PsycINFO, Embase), ClinicalTrials.gov, International Clinical Trials Registry Platform. Studies utilizing treat a trial setting were included. Results In total, 783 373 screened; 53 70 Published demonstrated low risk bias, assessed by Joanna Briggs Institute Critical Appraisal Tools. Neurocognitive, psychotic, depressive most common treated tACS. Both (58.5%) (52%) commonly utilized gamma frequency bands typically administered at an intensity 2 mA peak-to-peak, once daily 20 or fewer sessions. Although targeted locations montages varied across based outcome measures specific pathophysiology dorsolateral prefrontal cortex (DLPFC) target both (30.2%) (25.6%). Across that results measures, resulted enhanced symptoms and/or improvements overall psychopathology neurocognitive (all 11 studies), psychotic (11 out 14 (7 8 studies) disorders. Additionally, 17 reported alterations power spectrum electroencephalogram around entrained band following Conclusion Behavioral cognitive have been positively impacted The consistent changes gamma-tACS over DLPFC. However, paucity neuroimaging each condition highlights necessity replication employing biomarker- mechanism-centric approaches.

Язык: Английский

Parvalbumin interneuron cell-to-network plasticity: mechanisms and therapeutic avenues DOI Creative Commons
Michael D. Hadler, Henrik Alle,

Jörg R. P. Geiger

и другие.

Trends in Pharmacological Sciences, Год журнала: 2024, Номер 45(7), С. 586 - 601

Опубликована: Май 18, 2024

Alzheimer's disease (AD) and schizophrenia (SCZ) represent two major neuropathological conditions with a high burden. Despite their distinct etiologies, patients suffering from AD or SCZ share common burden of disrupted memory functions unattended by current therapies. Recent preclinical analyses highlight cell-type-specific contributions parvalbumin interneurons (PVIs), particularly the plasticity cellular excitability, towards intact neuronal network function (cell-to-network plasticity) performance. Here we argue that deficits PVI cell-to-network may underlie in SCZ, explore therapeutic avenues: targeting PVI-specific neuromodulation, including neuropeptides, recruitment synchrony gamma frequency range (40 Hz) external stimulation. We finally propose these approaches be merged under consideration recent insights into human brain physiology.

Язык: Английский

Процитировано

6
Effects of Transcranial Alternating Current Stimulation on Measures of Cognition and Symptom Scores in Chinese Patients with Schizophrenia DOI Creative Commons
Xinyi Cao, Yong Liu, Yong Lü

и другие.

Journal of Psychiatric Research, Год журнала: 2025, Номер 183, С. 10 - 15

Опубликована: Янв. 30, 2025

Язык: Английский

Процитировано

0
Therapeutic efficacy of transcranial direct current stimulation in treating auditory hallucinations in schizophrenia: A meta-analysis DOI

S Zou,

Jin-Nan Shi

World Journal of Psychiatry, Год журнала: 2025, Номер 15(3)

Опубликована: Фев. 26, 2025

Schizophrenia is a chronic psychiatric condition with complex symptomatology, including debilitating auditory hallucinations. Transcranial direct current stimulation (tDCS) has been explored as an adjunctive treatment to alleviate such symptoms. To evaluate the therapeutic efficacy of tDCS in schizophrenia. Adhering PRISMA guidelines, we systematically searched PubMed, Embase, Web Science, and Cochrane Library on September 19, 2023, for randomized controlled trials examining schizophrenia, no language or time restrictions. We included studies that compared control reported clinically relevant outcomes. Data extraction quality assessments were performed by independent evaluators using Collaboration's risk bias tool. Statistical heterogeneity was evaluated, random-effects model applied due moderate (I 2 = 41.3%). Nine comprising 425 participants (tDCS group: 219, 206) included. The meta-analysis demonstrated significant reduction hallucination scores following (weighted mean difference: -2.18, 95% confidence interval: -4.0 -0.29, P < 0.01). Sensitivity analysis confirmed robustness results, influence from individual studies. Additionally, publication not detected, supporting reliability generalizability findings. These results underscore intervention hallucinations significantly reduces suggesting its potential effective managing this disabling symptom. findings highlight practical significance clinical settings, particularly patients treatment-resistant

Язык: Английский

Процитировано

0
Efficacy and Safety of Bilateral Deep Brain Stimulation (DBS) for Severe Alzheimer's Disease: A Comparative Analysis of Fornix Versus Basal Ganglia of Meynert DOI Creative Commons
Junpeng Xu, Bin Liu,

Guosong Shang

и другие.

CNS Neuroscience & Therapeutics, Год журнала: 2025, Номер 31(4)

Опубликована: Апрель 1, 2025

ABSTRACT Background Deep brain stimulation (DBS) is a novel therapy for severe Alzheimer's disease (AD). However, there an ongoing debate regarding the optimal target DBS, particularly fornix and basal ganglia of Meynert (NBM). Objective This study aimed to investigate safety efficacy DBS AD compare NBM as potential targets. Methods We conducted prospective, nonrandomized clinical involving 20 patients with (MMSE score 0 10, CDR level 3) from January 2015 August 2022, comprising 12 males eight females, mean age 59.05 ± 6.45 years. All underwent treatment, among which 14 received bilateral implantation, while six implantation in NBM. Electrical commenced 1 month postoperatively. assessed before surgery, followed by evaluations at month, 3 months, 6 months poststimulation. Primary outcome measures focused on changes cognitive function, using MMSE, MoCA, ADAS‐Cog, scales. Secondary encompassed quality life, caregiver burden, neuropsychiatric symptoms, sleep disturbances, evaluated through BI, FAQ, FIM, ZBI, NPI, HAMA, HAMD, PSQI Results tolerated well, no serious adverse effects reported. Early on, significantly improved function life. Long‐term benefits include improvement symptoms disorders alleviation burden. Comparison between targeting revealed significant differences overall scale scores. upon deeper analysis, NBM‐DBS exhibited more pronounced NPI Conclusion therapeutic approach AD, capable improving patients' symptoms. Notably, showed distinct advantages ameliorating providing valuable insights clinically selecting target. Trial Registration ClinicalTrials.gov identifier: NCT03115814

Язык: Английский

Процитировано

0
Transcranial alternating current stimulation for investigating complex oscillatory dynamics and interactions DOI Creative Commons

Samira Barzegar,

Carolina F M Kakies,

Dorina Ciupercӑ

и другие.

International Journal of Psychophysiology, Год журнала: 2025, Номер 212, С. 112579 - 112579

Опубликована: Май 1, 2025

Neural oscillations play a fundamental role in human cognition and behavior. While electroencephalography (EEG) related methods provide precise temporal recordings of these oscillations, they are limited their ability to generate causal conclusions. Transcranial alternating current stimulation (tACS) has emerged as promising non-invasive neurostimulation technique modulate neural which offers insights into functional relation Originally, tACS is applied between two or more electrodes at given frequency. However, recent advances have aimed apply different waveforms target specific oscillatory dynamics. This systematic review evaluates the efficacy non-standard applications designed investigate patterns beyond simple sinusoidal stimulation. We categorized approaches three key domains: (1) phase synchronization techniques, including in-phase, anti-phase, traveling wave stimulation; (2) non-sinusoidal tACS, applies alternative such composite, broadband triangular oscillations; (3) amplitude-modulated interference stimulation, allow for concurrent EEG deeper cortical targeting. number studies evidence added value procedures, other show opposing null findings. Crucially, most currently low, such, goal this highlight both promise limitations providing foundation future research neurostimulation.

Язык: Английский

Процитировано

0
The effect of bilateral high-definition γ-tACS on negative symptoms and mismatch negativity in schizophrenia DOI
Liu Wen, Li Wan,

Yaqun Chen

и другие.

Journal of Psychiatric Research, Год журнала: 2025, Номер 188, С. 43 - 51

Опубликована: Май 23, 2025

Язык: Английский

Процитировано

0
Transcranial alternating current stimulation for neuropsychiatric disorders: a systematic review of treatment parameters and outcomes DOI Creative Commons

Fatemeh Gholamali Nezhad,

Josh Martin, Vanessa K. Tassone

и другие.

Frontiers in Psychiatry, Год журнала: 2024, Номер 15

Опубликована: Авг. 14, 2024

Background Transcranial alternating current stimulation (tACS) alters cortical excitability with low-intensity and thereby modulates aberrant brain oscillations. Despite the recent increase in studies investigating feasibility efficacy of tACS treating neuropsychiatric disorders, its mechanisms, as well optimal parameters, are not fully understood. Objectives This systematic review aimed to compile human research on for disorders delineate typical treatment parameters these conditions evaluate outcomes. Methods A search published unpublished registered clinical trials was conducted through OVID (MEDLINE, PsycINFO, Embase), ClinicalTrials.gov, International Clinical Trials Registry Platform. Studies utilizing treat a trial setting were included. Results In total, 783 373 screened; 53 70 Published demonstrated low risk bias, assessed by Joanna Briggs Institute Critical Appraisal Tools. Neurocognitive, psychotic, depressive most common treated tACS. Both (58.5%) (52%) commonly utilized gamma frequency bands typically administered at an intensity 2 mA peak-to-peak, once daily 20 or fewer sessions. Although targeted locations montages varied across based outcome measures specific pathophysiology dorsolateral prefrontal cortex (DLPFC) target both (30.2%) (25.6%). Across that results measures, resulted enhanced symptoms and/or improvements overall psychopathology neurocognitive (all 11 studies), psychotic (11 out 14 (7 8 studies) disorders. Additionally, 17 reported alterations power spectrum electroencephalogram around entrained band following Conclusion Behavioral cognitive have been positively impacted The consistent changes gamma-tACS over DLPFC. However, paucity neuroimaging each condition highlights necessity replication employing biomarker- mechanism-centric approaches.

Язык: Английский

Процитировано

1