Lifetime history of depression and eating behaviours: a co-twin control study of the TwinsUK registry DOI Creative Commons
Hiba Mutwalli, Moritz Herle, Carol Kan

и другие.

Journal of Affective Disorders, Год журнала: 2025, Номер 382, С. 264 - 273

Опубликована: Апрель 23, 2025

The extent to which depression impacts eating behaviours, and the mechanisms underpinning their relationship are unclear. We aim investigate between diagnosis behaviours. analysed data from 1426 participants of twins UK registry, includes 722 monozygotic (MZ) 702 dizygotic (DZ) twins. Eating behaviours were measured using three-factor questionnaire while antidepressant usage self-reported. Co-twin control design was used model association eating. Sensitivity tests implemented exclude those antidepressants. heritability estimates for 35 41 %. Twins with a history had higher scores on emotional (d = -0.31) constrained -0.18). intraclass correlations revealed covariation in MZ compared DZ A moderate observed lifetime uncontrolled (β 0.61, 95 % CI [0.17; 1.06]), 0.38, [0.22; 0.55]) restrained 0.43, [0.10; 0.77]). After removing antidepressants (n 195), attenuated, indicating potential influence this association. Our findings suggest can be partly explained by pre-existing genetic environmental vulnerabilities. Understanding underlying could guide development effective management strategies, including personalized nutrition plans, integrated mental dietary care, regular monitoring mitigate risk maladaptive disorders.

Язык: Английский

Mechanisms Involved in the Link between Depression, Antidepressant Treatment, and Associated Weight Change DOI Open Access

Tomas Kukucka,

Nikola Ferencová, Zuzana Višňovcová

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(8), С. 4511 - 4511

Опубликована: Апрель 20, 2024

Major depressive disorder is a severe mood associated with marked decrease in quality of life and social functioning, accompanied by risk suicidal behavior. Therefore, seeking out adhering to effective treatment great personal society-wide importance. Weight changes antidepressant therapy are often cited as the reason for withdrawal thus an important topic interest. There indeed exists significant mechanistic overlap between depression, treatment, regulation appetite body weight. The suggested pathomechanisms include abnormal functioning homeostatic (mostly humoral) hedonic dopaminergic) circuits regulation, well causing neuromorphological neurophysiological underlying development disorder. However, this issue still extensively discussed. This review aims summarize mechanisms linked depression context weight change.

Язык: Английский

Процитировано

8
The associations of anxiety, self-efficacy, and family health with obesity-related eating behavior among Chinese adults DOI

Junxu Lin,

Zijuan Ma,

H. Chen

и другие.

Journal of Affective Disorders, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Lifetime history of depression and eating behaviours: a co-twin control study of the TwinsUK registry DOI Creative Commons
Hiba Mutwalli, Moritz Herle, Carol Kan

и другие.

Journal of Affective Disorders, Год журнала: 2025, Номер 382, С. 264 - 273

Опубликована: Апрель 23, 2025

The extent to which depression impacts eating behaviours, and the mechanisms underpinning their relationship are unclear. We aim investigate between diagnosis behaviours. analysed data from 1426 participants of twins UK registry, includes 722 monozygotic (MZ) 702 dizygotic (DZ) twins. Eating behaviours were measured using three-factor questionnaire while antidepressant usage self-reported. Co-twin control design was used model association eating. Sensitivity tests implemented exclude those antidepressants. heritability estimates for 35 41 %. Twins with a history had higher scores on emotional (d = -0.31) constrained -0.18). intraclass correlations revealed covariation in MZ compared DZ A moderate observed lifetime uncontrolled (β 0.61, 95 % CI [0.17; 1.06]), 0.38, [0.22; 0.55]) restrained 0.43, [0.10; 0.77]). After removing antidepressants (n 195), attenuated, indicating potential influence this association. Our findings suggest can be partly explained by pre-existing genetic environmental vulnerabilities. Understanding underlying could guide development effective management strategies, including personalized nutrition plans, integrated mental dietary care, regular monitoring mitigate risk maladaptive disorders.

Язык: Английский

Процитировано

0