Inflammation in obsessive–compulsive disorder: A literature review and hypothesis‐based potential of transcranial photobiomodulation

Journal of Neuroscience Research, Год журнала: 2024, Номер 102(3)

Опубликована: Март 1, 2024

Abstract Obsessive–compulsive disorder (OCD) is a disabling neuropsychiatric that affects about 2%–3% of the global population. Despite availability several treatments, many patients with OCD do not respond adequately, highlighting need for new therapeutic approaches. Recent studies have associated various inflammatory processes pathogenesis OCD, including alterations in peripheral immune cells, cytokine levels, and neuroinflammation. These findings suggest inflammation could be promising target intervention. Transcranial photobiomodulation (t‐PBM) near‐infrared light noninvasive neuromodulation technique has shown potential disorders. However, its efficacy remains to fully explored. This study aimed review literature on detailing associations T‐cell populations, monocytes, NLRP3 inflammasome components, microglial activation, elevated proinflammatory cytokines such as TNF‐α, CRP, IL‐1β, IL‐6. We also examined hypothesis‐based t‐PBM targeting these pathways focusing mechanisms modulation oxidative stress, regulation cell function, reduction deactivation neurotoxic microglia, upregulation BDNF gene expression. Our suggests promising, intervention modulate underlying processes. Future research should focus randomized clinical trials assess t‐PBM's optimal treatment parameters OCD. Biomarker analyses neuroimaging will important understanding relationship between symptom improvement following sessions.

Язык: Английский

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Inflammation as a mediator between adverse childhood experiences and adult depression: A meta-analytic structural equation model

Journal of Affective Disorders, Год журнала: 2024, Номер 357, С. 85 - 96

Опубликована: Апрель 25, 2024

Exposure to adverse childhood experiences (ACEs) confers a higher risk of developing depression in adulthood, yet the mediation inflammation remains under debate. To test this model, we conducted systematic review and two-stage structural equation modelling meta-analysis studies reporting correlations between ACEs before age 18, inflammatory markers severity adulthood. Scopus, Pubmed, Medline, PsycInfo, CINAHL were searched up 2 October 2023. Twenty-two data on C-reactive protein (CRP, n = 12,935), interleukin-6 (IL-6, 4108), tumour necrosis factor-α (TNF-α, 2256) composite measures (n 1674) included. Unadjusted models revealed that CRP (β 0.003, 95 % LBCI 0.0002 0.0068), IL-6 0.001 0.006), 0.009, 0.004 0.018) significantly mediated association adult depression. The effects no longer survived after adjusting for BMI; however, serial model BMI sequentially 0.002, 0.0005 0.0046), accounting 14.59 9.94 variance depressive symptoms, respectively. Due cross-sectional nature assessment findings should be approached with caution; results suggest complex interactions psychoneuroimmunological metabolic factors underlie adulthood

Язык: Английский

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Five Hypothesized Biological Mechanisms Linking Adverse Childhood Experiences with Anxiety, Depression, and PTSD: A Scoping Review

Neuroscience & Biobehavioral Reviews, Год журнала: 2025, Номер unknown, С. 106062 - 106062

Опубликована: Фев. 1, 2025

Язык: Английский

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Methylation profile scores of environmental exposures and risk of relapse after a first episode of schizophrenia

European Neuropsychopharmacology, Год журнала: 2025, Номер 94, С. 4 - 15

Опубликована: Фев. 16, 2025

Язык: Английский

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Impact of gene-by-trauma interaction in MDD-related multimorbidity clusters

Journal of Affective Disorders, Год журнала: 2024, Номер 359, С. 382 - 391

Опубликована: Май 26, 2024

Major depressive disorder (MDD) is considerably heterogeneous in terms of comorbidities, which may hamper the disentanglement its biological mechanism. In a previous study, we classified lifetime trajectories MDD-related multimorbidities into seven distinct clusters, each characterized by unique genetic and environmental risk-factor profiles. The current objective was to investigate genome-wide gene-by-environment (G × E) interactions with childhood trauma burden, within context these clusters.

Язык: Английский

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Potential Metabolic Sequelae to the Terrorist Attack of October 7th, 2023

Journal of Psychiatric Research, Год журнала: 2025, Номер 182, С. 452 - 461

Опубликована: Янв. 22, 2025

Язык: Английский

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Biological pathways underlying the relationship between childhood maltreatment and Multimorbidity: A Two-Step, multivariable Mendelian randomisation study

Brain Behavior and Immunity, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Unclean cooking fuel use and all health outcomes, a systematic review and meta-analysis

Опубликована: Фев. 26, 2025

Язык: Английский

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Differential immune profiles in the context of chronic stress among childhood adversity-exposed adolescents

Brain Behavior and Immunity, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Rethinking Depression—Beyond Neurotransmitters: An Integrated Psychoneuroendocrineimmunology Framework for Depression’s Pathophysiology and Tailored Treatment

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2759 - 2759

Опубликована: Март 19, 2025

It is known that the effectiveness of drug treatment for depression, ammine deficit based, largely unsatisfactory. In this review, we examine proposal a precision therapy has emerged and received strong push by identification role inflammation in depression. However, psychiatry risks being caught reductionist trap searching molecular switch resets whole system switches off disease. This an illusion since human complex depression systemic variable disorder. study, show inadequacy paradigm, and, at same time, illustrate superiority paradigm centered on psychoneuroendocrineimmunology (PNEI). According to PNEI disease being, caused different sources working together: psychological, biological, behavioral. means knowing biological psychological history subject, identifying relational crisis factors, building personalized treatments targeting those factors with tools medicine psychology, which are not reducible combination drugs psychotherapy. Our presents shift both theoretical practical, enables clinicians assess patients experiencing unified way treat them integrated manner.

Язык: Английский

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