Inflammation in obsessive–compulsive disorder: A literature review and hypothesis‐based potential of transcranial photobiomodulation

Journal of Neuroscience Research, Journal Year: 2024, Volume and Issue: 102(3)

Published: March 1, 2024

Abstract Obsessive–compulsive disorder (OCD) is a disabling neuropsychiatric that affects about 2%–3% of the global population. Despite availability several treatments, many patients with OCD do not respond adequately, highlighting need for new therapeutic approaches. Recent studies have associated various inflammatory processes pathogenesis OCD, including alterations in peripheral immune cells, cytokine levels, and neuroinflammation. These findings suggest inflammation could be promising target intervention. Transcranial photobiomodulation (t‐PBM) near‐infrared light noninvasive neuromodulation technique has shown potential disorders. However, its efficacy remains to fully explored. This study aimed review literature on detailing associations T‐cell populations, monocytes, NLRP3 inflammasome components, microglial activation, elevated proinflammatory cytokines such as TNF‐α, CRP, IL‐1β, IL‐6. We also examined hypothesis‐based t‐PBM targeting these pathways focusing mechanisms modulation oxidative stress, regulation cell function, reduction deactivation neurotoxic microglia, upregulation BDNF gene expression. Our suggests promising, intervention modulate underlying processes. Future research should focus randomized clinical trials assess t‐PBM's optimal treatment parameters OCD. Biomarker analyses neuroimaging will important understanding relationship between symptom improvement following sessions.

Language: Английский

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Inflammation as a mediator between adverse childhood experiences and adult depression: A meta-analytic structural equation model

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 357, P. 85 - 96

Published: April 25, 2024

Exposure to adverse childhood experiences (ACEs) confers a higher risk of developing depression in adulthood, yet the mediation inflammation remains under debate. To test this model, we conducted systematic review and two-stage structural equation modelling meta-analysis studies reporting correlations between ACEs before age 18, inflammatory markers severity adulthood. Scopus, Pubmed, Medline, PsycInfo, CINAHL were searched up 2 October 2023. Twenty-two data on C-reactive protein (CRP, n = 12,935), interleukin-6 (IL-6, 4108), tumour necrosis factor-α (TNF-α, 2256) composite measures (n 1674) included. Unadjusted models revealed that CRP (β 0.003, 95 % LBCI 0.0002 0.0068), IL-6 0.001 0.006), 0.009, 0.004 0.018) significantly mediated association adult depression. The effects no longer survived after adjusting for BMI; however, serial model BMI sequentially 0.002, 0.0005 0.0046), accounting 14.59 9.94 variance depressive symptoms, respectively. Due cross-sectional nature assessment findings should be approached with caution; results suggest complex interactions psychoneuroimmunological metabolic factors underlie adulthood

Language: Английский

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Five Hypothesized Biological Mechanisms Linking Adverse Childhood Experiences with Anxiety, Depression, and PTSD: A Scoping Review

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106062 - 106062

Published: Feb. 1, 2025

Language: Английский

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Potential Metabolic Sequelae to the Terrorist Attack of October 7th, 2023

Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: 182, P. 452 - 461

Published: Jan. 22, 2025

Language: Английский

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Methylation profile scores of environmental exposures and risk of relapse after a first episode of schizophrenia

European Neuropsychopharmacology, Journal Year: 2025, Volume and Issue: 94, P. 4 - 15

Published: Feb. 16, 2025

Language: Английский

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Unclean cooking fuel use and all health outcomes, a systematic review and meta-analysis

Published: Feb. 26, 2025

Language: Английский

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Differential immune profiles in the context of chronic stress among childhood adversity-exposed adolescents

Brain Behavior and Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Altered Brain Functional Connectivity and Peripheral Transcriptomic Profiles in Major Depressive Disorder With Childhood Maltreatment

Depression and Anxiety, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Background: Childhood maltreatment (CM) is a significant risk factor for major depressive disorder (MDD), yet the underlying biological mechanisms remain unclear. This study aimed to investigate brain functional networks and peripheral transcriptomics in patients with MDD who have history of CM. Methods: Functional imaging data were collected network-based statistics used identify differences among CM (MDD_CM, n = 78), without (MDD_nCM, 61), healthy controls (HC, 126). Additionally, blood transcriptional clustered into co-expression modules, module differential connectivity analysis was utilized assess variations gene network modules groups. Results: The results revealed difference an inferior occipital gyrus-centered three Furthermore, eight differed groups enriched multiple branches related immune responses or metabolic processes. Notably, type I interferon-related signaling pathways demonstrated correlation disrupted MDD_nCM group. Moreover, immune-related found be significantly correlated sleep disturbances MDD_CM patients. Conclusions: Dysregulation transcriptomic alterations associate pathophysiology MDD_CM.

Language: Английский

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Inflammation and Minority Stress: A Moderated Mediation Model of Childhood Adversity and Mental Health in Young Men Who Have Sex with Men

Social Science & Medicine, Journal Year: 2025, Volume and Issue: 376, P. 118119 - 118119

Published: April 23, 2025

Language: Английский

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Epigenetic changes caused by early life stress in the pathogenesis of depression

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177671 - 177671

Published: April 1, 2025

Language: Английский

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