Women s Health and Reproduction,
Год журнала:
2024,
Номер
61(1)
Опубликована: Янв. 1, 2024
Aim.
To
study
the
controversial
issues
of
diagnosis
and
treatment
chronic
endometritis
(CE)
its
impact
on
fertility,
according
to
foreign
domestic
authors.
Key
points.
Although
immunohistochemical
for
plasma
cells
is
considered
gold
standard
diagnosing
CE,
it
has
limitations.
The
need
achieve
consensus
diagnostic
criteria
cholecystitis
was
noted
in
order
exclude
influence
heterogeneity
studies
assessment
results.
An
integrated
approach
based
knowledge
about
pathogenesis
CE
facilitates
selection
adequate
treatment.
positive
role
antibacterial
therapy
resolving
undoubted.
In
recent
years,
restore
immune
defense
been
widely
discussed.
importance
a
complex
natural
antimicrobial
peptides
cytokines
restoring
fertility
improving
pregnancy
outcomes
already
proven
several
publications.
Physiotherapeutic
methods
continue
be
studied,
most
popular
currently
are
cavitated
solutions,
peloids,
electropulse
magnetic
therapy.
Conclusion.
require
clear
definition.
Treatment
should
include
broad-spectrum
antibiotic
therapy,
immunomodulatory
physiotherapy.
Keywords:
endometritis,
infertility,
recurrent
miscarriage,
antibiotics,
immunomodulators,
peloid
ultrasonic
cavitation,
interference
magnetotherapy,
laser
Journal of Obstetrics and Gynaecology Research,
Год журнала:
2022,
Номер
49(1), С. 243 - 252
Опубликована: Окт. 24, 2022
Abstract
Aim
The
chronic
endometritis
(CE)
prevalence
in
people
experiencing
infertility
is
2.8–56.8%,
pregnancy
rates
patients
with
increase
after
hysterosalpingography
oil‐based
contrast,
but
the
effect
and
mechanism
are
not
clear.
Here,
we
analyzed
effects
of
intrauterine
ethiodized
poppyseed
oil
(EPO)
bathing
on
a
rat
model
CE
possible
underlying
mechanism.
Methods
rats
were
induced
by
lipopolysaccharide
(LPS)
exposure,
subjected
to
EPO
or
phosphate‐buffered
saline
(PBS)
verification.
Serum
uterus
levels
IFN‐γ,
IL‐4,
TNF‐α,
IL‐1β
detected
ELISA
kit,
number
CD138
+
CD68
cells
uterine
IL‐1β,
NF‐κB
P65
expression
immunohistochemistry
bathing.
Results
LPS
exposure
typical
phenotype
phagocyte
infiltration
endometrial
stroma.
Compared
PBS
bathing,
showed
decreases
populations
significant
serum
IFN‐γ
levels,
moreover,
IL‐4
slightly
higher,
IFN‐γ/IL‐4(Th1/Th2‐type
cytokine
ratio)
was
significantly
lower.
Local
endometrium
downregulated,
while
upregulated.
Conclusion
Intrauterine
contrast
alleviated
local
inflammation
downregulating
expression,
reducing
IFN–γ
(Th1),
increasing
(Th2)
endometrium,
regulating
Th1/Th2‐type
trends
toward
Th2.
Seminars in Reproductive Medicine,
Год журнала:
2021,
Номер
39(01/02), С. 013 - 023
Опубликована: Март 1, 2021
Abstract
Fetal
implantation
requires
carefully
orchestrated
involvement
of
the
maternal
immune
system.
Aberrant
function
within
has
been
suggested
as
a
cause
failure.
The
emergence
immunological
theories
miscarriage
led
to
testing
an
adjuvant
treatment
in
assisted
reproductive
technology;
however,
it
remains
controversial,
with
mixed
evidence
both
for
and
benefits
testing.
Literature
on
common
methods
technology
is
reviewed
including
those
peripheral
uterine
natural
killer
cells,
chronic
endometritis,
T-helper
cells
cytokine
ratio.
There
little
consensus
context
recurrent
field
limited
by
lack
uniformity
approach
heterogeneity
pathophysiological
cause.
Nevertheless,
system
heavily
involved
new
era
personalized
medicine
ensures
that
more
defined
will
be
achieved.
Women s Health and Reproduction,
Год журнала:
2024,
Номер
61(1)
Опубликована: Янв. 1, 2024
Aim.
To
study
the
controversial
issues
of
diagnosis
and
treatment
chronic
endometritis
(CE)
its
impact
on
fertility,
according
to
foreign
domestic
authors.
Key
points.
Although
immunohistochemical
for
plasma
cells
is
considered
gold
standard
diagnosing
CE,
it
has
limitations.
The
need
achieve
consensus
diagnostic
criteria
cholecystitis
was
noted
in
order
exclude
influence
heterogeneity
studies
assessment
results.
An
integrated
approach
based
knowledge
about
pathogenesis
CE
facilitates
selection
adequate
treatment.
positive
role
antibacterial
therapy
resolving
undoubted.
In
recent
years,
restore
immune
defense
been
widely
discussed.
importance
a
complex
natural
antimicrobial
peptides
cytokines
restoring
fertility
improving
pregnancy
outcomes
already
proven
several
publications.
Physiotherapeutic
methods
continue
be
studied,
most
popular
currently
are
cavitated
solutions,
peloids,
electropulse
magnetic
therapy.
Conclusion.
require
clear
definition.
Treatment
should
include
broad-spectrum
antibiotic
therapy,
immunomodulatory
physiotherapy.
Keywords:
endometritis,
infertility,
recurrent
miscarriage,
antibiotics,
immunomodulators,
peloid
ultrasonic
cavitation,
interference
magnetotherapy,
laser
