Association between atherogenic index of plasma and infertility: a cross-sectional study based on U.S. women
Lipids in Health and Disease,
Год журнала:
2025,
Номер
24(1)
Опубликована: Фев. 14, 2025
A
wealth
of
evidence
indicates
that
dyslipidemia
is
associated
with
endothelial
dysfunction,
oxidative
stress,
and
inflammation,
each
which
can
impair
reproductive
function
lead
to
infertility.
The
Atherogenic
Index
Plasma
(AIP)
an
innovative
lipid
biomarker
combines
the
triglyceride
high-density
lipoprotein
cholesterol
(HDL-C)
ratio,
providing
a
more
in-depth
evaluation
metabolism.
This
synthesizes
discrete
disruptions
into
single
value,
surpassing
isolated
indicators'
diagnostic
value.
primary
goal
our
study
was
explore
link
between
AIP
incidence
Data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
spanning
2013–2018
were
subjected
cross-sectional
examination.
determined
through
logarithmic
transformation
(base
10)
triglyceride-to-HDL-C
ratio.
To
uncover
connection
infertility,
suite
analytical
techniques
employed,
encompassing
weighted
multiple
logistic
regression,
stratified
analyses,
spline
curve
modeling,
determination
cutoff
values.
Among
1,191
participants,
mean
age
31.89
years,
12.09%
diagnosed
as
infertile.
multivariate-adjusted
odds
ratios
for
infertility
occurrence
across
quartiles
1.00
(reference),
1.96
(95%
CI:
1.10–3.49),
2.62
1.48–4.63),
2.38
1.31–4.32),
respectively.
Subgroup
examinations
suggest
association
remains
robust
not
substantially
altered
by
factors
including
age,
marital
status,
economic
tobacco
use,
alcohol
intake,
body
mass
index.
Curve
fitting
threshold
analyses
have
indicated
positive
nonlinear
relationship
well
relatively
stable
within
range
-0.21
0.22.
Incorporating
assessment
clinical
could
potentially
refine
accuracy
risk
estimation
patients.
Язык: Английский
Dyslipidemia and female reproductive failures: perspectives on lipid metabolism and endometrial immune dysregulation
Seminars in Immunopathology,
Год журнала:
2025,
Номер
47(1)
Опубликована: Фев. 18, 2025
Язык: Английский
PPAR-gamma agonist pioglitazone improves endometrial receptivity, reverses endometrial barrier disruption and promotes ovarian function in thin endometrium rats via modulation PPAR-γ/Wnt5/β-catenin pathway
Journal of Reproductive Immunology,
Год журнала:
2025,
Номер
unknown, С. 104526 - 104526
Опубликована: Март 1, 2025
Язык: Английский