Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
11
Опубликована: Янв. 19, 2024
There
has
been
increasing
attention
to
produce
porous
scaffolds
that
mimic
human
bone
properties
for
enhancement
of
tissue
ingrowth,
regeneration,
and
integration.
Additive
manufacturing
(AM)
technologies,
i.e.,
three
dimensional
(3D)
printing,
have
played
a
substantial
role
in
engineering
clinical
applications
owing
their
high
level
design
fabrication
flexibility.
To
this
end,
review
article
attempts
provide
detailed
overview
on
the
main
considerations
such
as
permeability,
adhesion,
vascularisation,
interfacial
features
interplay
affect
regeneration
osseointegration.
Physiology
was
initially
explained
followed
by
analysing
impacts
porosity,
pore
size,
permeability
surface
chemistry
defects.
Importantly,
major
3D
printing
methods
employed
substitutes
were
also
discussed.
Advancements
MA
technologies
allowed
production
with
complex
geometries
polymers,
composites
metals
well-tailored
architectural,
mechanical,
mass
transport
features.
In
way,
particular
devoted
reviewing
printed
triply
periodic
minimal
(TPMS)
hierarchical
structure
bones.
overall,
enlighten
pathway
patient-specific
3D-printed
substitutions
osseointegration
capacity
repairing
large
Advanced Functional Materials,
Год журнала:
2021,
Номер
31(21)
Опубликована: Март 8, 2021
Abstract
Bone
tissue
engineering
(BTE)
is
a
rapidly
growing
field
aiming
to
create
biofunctional
that
can
integrate
and
degrade
in
vivo
treat
diseased
or
damaged
tissue.
It
has
become
evident
scaffold
fabrication
techniques
are
very
important
dictating
the
final
structural,
mechanical
properties,
biological
response
of
implanted
biomaterials.
A
comprehensive
review
current
accomplishments
on
techniques,
their
structure,
function
properties
for
BTE
provided
herein.
Different
types
biomaterials
ranging
from
inorganic
natural
synthetic
polymers
related
composites
processing
presented.
Emergent
scaffolding
such
as
electrospinning,
freeze‐drying,
bioprinting,
decellularization
also
discussed.
Strategies
improve
vascularization
potential
immunomodulation,
which
considered
grand
challenge
scaffolding,
Advanced Healthcare Materials,
Год журнала:
2022,
Номер
12(9)
Опубликована: Дек. 13, 2022
Bone
tissue
engineering
(BTE)
is
a
topic
of
interest
for
the
last
decade,
and
advances
in
materials,
processing
techniques,
understanding
bone
healing
pathways
have
opened
new
avenues
research.
The
dual
responsibility
BTE
scaffolds
providing
load-bearing
capability
interaction
with
local
extracellular
matrix
to
promote
challenge
synthetic
scaffolds.
This
article
describes
usage
multi-materials
hierarchical
structures
mimic
structure
natural
tissues
function
as
bioactive
first
part
this
literature
review
physiology
responses
interactions
at
different
stages
repair.
following
section
reviews
available
on
biomaterials
used
followed
by
some
multi-material
approaches.
next
discusses
impact
scaffold's
structural
features
necessity
distribution
scaffold
structure.
Finally,
highlights
emerging
trends
developments
that
can
inspire
strategies
truly
develop
generation
Advanced Functional Materials,
Год журнала:
2022,
Номер
32(34)
Опубликована: Июнь 24, 2022
Abstract
MXenes
(viz.,
transition
metal
carbides,
carbonitrides,
and
nitrides)
have
emerged
as
a
new
subclass
of
2D
materials.
Due
to
their
outstanding
physicochemical
biological
properties,
gained
much
attention
in
the
biomedical
field
recent
years,
including
drug
delivery
systems,
regenerative
medicine,
biosensing.
Additionally,
incorporation
into
hydrogels
has
garnered
significant
interest
engineering
an
electroactive
mechanical
nanoreinforcer
capable
converting
nonconductive
scaffolds
excellent
conductors
electricity
with
impressive
effect
on
properties
for
organs
tissues
such
cardiac,
skeletal
muscle,
nerve.
However,
many
questions
problems
remain
unresolved
that
need
be
answered
usher
these
materials
toward
true
destiny.
Thus,
this
review
paper
aims
provide
overview
design
applications
MXene‐integrated
composites
applications,
cardiac
tissue
engineering,
wound
healing,
infection
therapy,
cancer
biosensors.
Moreover,
current
challenges
limitations
utilizing
vivo
are
highlighted
discussed,
followed
by
its
prospects
guideline
possible
various
futuristic
applications.
This
article
will
inspire
researchers,
who
search
opportunities,
using
nanomaterial
Polymers,
Год журнала:
2021,
Номер
13(16), С. 2642 - 2642
Опубликована: Авг. 9, 2021
Collagen
type
I
(Col-I)
is
unique
due
to
its
high
biocompatibility
in
human
tissue.
Despite
availability
from
various
sources,
Col-I
naturally
mimics
the
extracellular
matrix
(ECM)
and
generally
makes
up
larger
protein
component
(90%)
vasculature,
skin,
tendon
bone,
other
The
acceptable
physicochemical
properties
of
native
further
enhance
incorporation
fields,
including
pharmaceutical,
cosmeceutical,
regenerative
medicine,
clinical.
This
review
aims
discuss
Col-I,
covering
structure,
sources
availability,
collagen
synthesis,
current
extraction
methods,
characteristics,
applications
biomarkers.
intended
provide
specific
information
on
currently
available,
going
back
five
years.
expected
a
helping
hand
for
researchers
who
are
concerned
about
any
development
collagen-based
products
particularly
therapeutic
fields.
Materials & Design,
Год журнала:
2021,
Номер
210, С. 110066 - 110066
Опубликована: Авг. 23, 2021
Poly
(lactic
acid)
(PLA)
with
good
biodegradability,
biocompatibility
and
processability
has
a
wide
application
prospect
in
bone
tissue
engineering.
However,
PLA
exhibits
very
slow
degradation
rate,
hindering
the
regeneration
of
new
bone.
In
this
study,
mechanisms
scaffold,
including
autocatalysis
non-catalysis,
end-chain
random
chain
breaking,
surface
bulk
degradation,
were
analyzed
systematically,
influence
factors
crystallinity,
molecular
weight,
pH,
so
on,
introduced.
On
basis,
strategies
blending,
copolymerization,
compounding
modification
to
accelerate
summarized,
accelerating
discussed
detailedly.
addition,
rapid
prototyping
technologies
unique
advantages
on
structure
shape
scaffold
The
mechanical
properties
(strength
modulus)
biological
(in
vivo
vitro)
reviewed
discussed.
Finally,
present
problem
research
simultaneous
improvement
was
put
forward,
four-dimensional
printing
(4D
printing)
as
an
advanced
technique
which
might
bring
ideas
improve
extend
mentioned.
Bioactive Materials,
Год журнала:
2022,
Номер
18, С. 383 - 398
Опубликована: Фев. 23, 2022
Bone
defects
caused
by
trauma,
tumor,
congenital
abnormality
and
osteoarthritis,
etc.
have
been
substantially
impacted
the
lives
health
of
human.
Artificial
bone
implants,
like
bioceramic-based
scaffolds,
provide
significant
benefits
over
biological
counterparts
are
critical
for
repair
regeneration.
However,
it
is
highly
probable
that
bacterial
infections
occur
in
surgical
procedures
or
on
scaffolds.
Therefore,
great
significance
to
obtain
scaffolds
with
integrative
antibacterial
osteogenic
functions
treating
implant-associated
infection
promoting
repair.
To
fight
against
problems,
various
strategies
developed
regeneration
also
made
progresses.
This
review
summarizes
recent
progresses
function,
which
include
drug-induced,
ion-mediated,
physical-activated
their
combined
according
specific
mechanism.
Finally,
challenges
opportunities
discussed.
