Bone Tissue Engineering Scaffolds: Function of Multi‐Material Hierarchically Structured Scaffolds

Advanced Healthcare Materials, Год журнала: 2022, Номер 12(9)

Опубликована: Дек. 13, 2022

Bone tissue engineering (BTE) is a topic of interest for the last decade, and advances in materials, processing techniques, understanding bone healing pathways have opened new avenues research. The dual responsibility BTE scaffolds providing load-bearing capability interaction with local extracellular matrix to promote challenge synthetic scaffolds. This article describes usage multi-materials hierarchical structures mimic structure natural tissues function as bioactive first part this literature review physiology responses interactions at different stages repair. following section reviews available on biomaterials used followed by some multi-material approaches. next discusses impact scaffold's structural features necessity distribution scaffold structure. Finally, highlights emerging trends developments that can inspire strategies truly develop generation

Язык: Английский

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Multimaterial 3D and 4D Bioprinting of Heterogenous Constructs for Tissue Engineering

Advanced Materials, Год журнала: 2023, Номер 36(34)

Опубликована: Сен. 22, 2023

Additive manufacturing (AM), which is based on the principle of layer-by-layer shaping and stacking discrete materials, has shown significant benefits in fabrication complicated implants for tissue engineering (TE). However, many native tissues exhibit anisotropic heterogenous constructs with diverse components functions. Consequently, replication biomimetic using conventional AM processes a single material challenging. Multimaterial 3D 4D bioprinting (with time as fourth dimension) emerged promising solution constructing multifunctional that can mimic host microenvironment better than single-material alternatives. Notably, 4D-printed multimaterial architectures provide time-dependent programmable dynamic promote cell activity regeneration response to external stimuli. This paper first presents typical design strategies TE applications. Subsequently, latest are discussed, along their advantages challenges. In particular, potential smart highlighted. Furthermore, this review provides insights into how facilitate realization next-generation

Язык: Английский

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Engineering Large‐Scale Self‐Mineralizing Bone Organoids with Bone Matrix‐Inspired Hydroxyapatite Hybrid Bioinks

Advanced Materials, Год журнала: 2024, Номер 36(30)

Опубликована: Апрель 20, 2024

Abstract Addressing large bone defects remains a significant challenge owing to the inherent limitations in self‐healing capabilities, resulting prolonged recovery and suboptimal regeneration. Although current clinical solutions are available, they have notable shortcomings, necessitating more efficacious approaches Organoids derived from stem cells show great potential this field; however, development of organoids has been hindered by specific demands, including need for robust mechanical support provided scaffolds hybrid extracellular matrices (ECM). In context, bioprinting technologies emerged as powerful means replicating complex architecture tissue. The research focused on fabrication highly intricate ECM analog using novel bioink composed gelatin methacrylate/alginate methacrylate/hydroxyapatite (GelMA/AlgMA/HAP). Bioprinted facilitate long‐term cultivation progressive maturation extensive bioprinted organoids, foster multicellular differentiation, offer valuable insights into initial stages formation. intrinsic self‐mineralizing quality closely emulates properties natural bone, empowering with enhanced repair both vitro vivo applications. This trailblazing investigation propels field tissue engineering holds promise its translation practical

Язык: Английский

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Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration

Advanced Materials, Год журнала: 2024, Номер 36(34)

Опубликована: Июнь 11, 2024

The repair and functional reconstruction of bone defects resulting from severe trauma, surgical resection, degenerative disease, congenital malformation pose significant clinical challenges. Bone tissue engineering (BTE) holds immense potential in treating these defects, without incurring prevalent complications associated with conventional autologous or allogeneic grafts. 3D printing technology enables control over architectural structures at multiple length scales has been extensively employed to process biomimetic scaffolds for BTE. In contrast inert grafts, next-generation smart possess a remarkable ability mimic the dynamic nature native extracellular matrix (ECM), thereby facilitating regeneration. Additionally, they can generate tailored controllable therapeutic effects, such as antibacterial antitumor properties, response exogenous and/or endogenous stimuli. This review provides comprehensive assessment progress 3D-printed BTE applications. It begins an introduction physiology, followed by overview technologies utilized scaffolds. Notable advances various stimuli-responsive strategies, efficacy, applications are discussed. Finally, highlights existing challenges development implementation scaffolds, well emerging this field.

Язык: Английский

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An overview of selective laser sintering 3D printing technology for biomedical and sports device applications: Processes, materials, and applications

Optics & Laser Technology, Год журнала: 2023, Номер 171, С. 110459 - 110459

Опубликована: Дек. 21, 2023

Язык: Английский

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Bone tissue engineering scaffold materials: Fundamentals, advances, and challenges

Chinese Chemical Letters, Год журнала: 2023, Номер 35(2), С. 109197 - 109197

Опубликована: Окт. 14, 2023

Язык: Английский

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Developing fibrin-based biomaterials/scaffolds in tissue engineering

Bioactive Materials, Год журнала: 2024, Номер 40, С. 597 - 623

Опубликована: Авг. 15, 2024

Tissue engineering technology has advanced rapidly in recent years, offering opportunities to construct biologically active tissues or organ substitutes repair even enhance the functions of diseased and organs. Tissue-engineered scaffolds rebuild extracellular microenvironment by mimicking matrix. Fibrin-based possess numerous advantages, including hemostasis, high biocompatibility, good degradability. Fibrin provide an initial matrix that facilitates cell migration, differentiation, proliferation, adhesion, also play a critical role cell-matrix interactions. are now widely recognized as key component tissue engineering, where they can facilitate defect repair. This review introduces properties fibrin, its composition, structure, biology. In addition, modification cross-linking modes fibrin discussed, along with various forms commonly used engineering. We describe biofunctionalization fibrin. provides detailed overview use applications skin, bone, nervous tissues, novel insights into future research directions for clinical treatment.

Язык: Английский

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Current Perspectives of Protein in Bone Tissue Engineering: Bone Structure, Ideal Scaffolds, Fabrication Techniques, Applications, Scopes, and Future Advances

ACS Applied Bio Materials, Год журнала: 2024, Номер 7(8), С. 5082 - 5106

Опубликована: Июль 15, 2024

In view of their exceptional approach, excellent inherent biocompatibility and biodegradability properties, interaction with the local extracellular matrix, protein-based polymers have received attention in bone tissue engineering, which is a multidisciplinary field that repairs regenerates fractured bones. Bone multihierarchical complex structure, it performs several essential biofunctions, including maintaining mineral balance structural support protecting soft organs. Protein-based gained interest developing ideal scaffolds as emerging biomaterials for healing regeneration, challenging to design substitutes perfect biomaterials. Several polymers, collagen, keratin, gelatin, serum albumin, etc., are potential materials due cytocompatibility, controlled biodegradability, high biofunctionalization, tunable mechanical characteristics. While numerous studies indicated encouraging possibilities proteins BTE, there still major challenges concerning stability physiological conditions, continuous release growth factors bioactive molecules. Robust derived from can be used replace broken or diseased biocompatible substitute; proteins, being biopolymers, provide engineering. Herein, recent developments protein cutting-edge engineering addressed this review within 3–5 years, focus on significant future perspectives. The first section discusses fundamentals anatomy scaffolds, second describes fabrication techniques scaffolds. third highlights importance applications BTE. Hence, development state-of-the-art has been discussed, highlighting

Язык: Английский

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Organic–inorganic composite hydrogels: compositions, properties, and applications in regenerative medicine

Biomaterials Science, Год журнала: 2024, Номер 12(5), С. 1079 - 1114

Опубликована: Янв. 1, 2024

Hydrogels, formed from crosslinked hydrophilic macromolecules, provide a three-dimensional microenvironment that mimics the extracellular matrix. They served as scaffold materials in regenerative medicine with an ever-growing demand. However, hydrogels composed of only organic components may not fully meet performance and functionalization requirements for various tissue defects. Composite hydrogels, containing inorganic components, have attracted tremendous attention due to their unique compositions properties. Rigid particles, rods, fibers,

Язык: Английский

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Novel Decellularization Scheme for Preparing Acellular Fish Scale Scaffolds for Bone Tissue Engineering

ACS Omega, Год журнала: 2025, Номер 10(1), С. 230 - 238

Опубликована: Янв. 1, 2025

In bone tissue engineering, a suitable scaffold is the key. Due to their similar composition tissue, special structure, good mechanical properties, and osteogenic acellular fish scale scaffolds are potential for engineering. At present, decellularization scheme mostly uses combination of sodium dodecyl sulfate ethylenediamine tetraacetic acid (EDTA), but this method has problems. We optimized using combined Triton X-100, EDTA, nuclease. study, optimal was screened with respect effect, extracellular matrix structure retention, cell biocompatibility, differentiation ability. The results showed that as follows: native scales were incubated in 0.1% EDTA 24 h, then cellular components removed 1% X-100 4 days, followed by nuclease digestion h. On basis, we proposed novel more scheme, prepared may have great

Язык: Английский

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