ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 27, 2025
Piezoelectricity
is
reported
to
be
able
promote
bone
scaffolds
with
excellent
osteogenic
performance.
Herein,
barium
titanate/β-tricalcium
phosphate
(BTO/β-TCP)
piezoelectric
composite
were
3D
printed,
and
their
performances
investigated
in
detail.
The
fabrication
of
BTO/β-TCP
employed
cutting-edge
DLP
printing
technology.
scaffolds,
featuring
a
triply
periodic
minimal
surface
(TPMS)
design
porosity
60%,
offered
unique
structural
framework.
A
comprehensive
assessment
the
composition,
properties,
mechanical
characteristics
was
conducted.
Notably,
an
increase
BTO
volume
fraction
from
50
80
vol
%
within
led
reduction
compressive
strength,
decreasing
2.47
1.74
MPa.
However,
this
variation
accompanied
by
substantial
enhancement
constant
d33,
soaring
1.4
pC/N
21.6
pC/N.
Utilizing
mouse
osteoblasts
(MC3T3-E1)
live/dead
cell
staining
assay,
under
influence
external
ultrasound,
demonstrated
commendable
biocompatibility
these
ceramic
scaffolds.
Furthermore,
thorough
analyses
alkaline
phosphatase
(ALP)
activity
polymerase
chain
reaction
(PCR)
findings
provided
compelling
evidence
scaffolds'
superior
underpinning
effectiveness
at
cellular
protein
gene
levels.
In
conclusion,
study
offers
groundbreaking
strategy
for
employment
implant
applications,
harnessing
blend
biocompatibility,
piezoelectricity,
potential.
Advanced Healthcare Materials,
Год журнала:
2022,
Номер
12(9)
Опубликована: Дек. 13, 2022
Bone
tissue
engineering
(BTE)
is
a
topic
of
interest
for
the
last
decade,
and
advances
in
materials,
processing
techniques,
understanding
bone
healing
pathways
have
opened
new
avenues
research.
The
dual
responsibility
BTE
scaffolds
providing
load-bearing
capability
interaction
with
local
extracellular
matrix
to
promote
challenge
synthetic
scaffolds.
This
article
describes
usage
multi-materials
hierarchical
structures
mimic
structure
natural
tissues
function
as
bioactive
first
part
this
literature
review
physiology
responses
interactions
at
different
stages
repair.
following
section
reviews
available
on
biomaterials
used
followed
by
some
multi-material
approaches.
next
discusses
impact
scaffold's
structural
features
necessity
distribution
scaffold
structure.
Finally,
highlights
emerging
trends
developments
that
can
inspire
strategies
truly
develop
generation
Advanced Materials,
Год журнала:
2023,
Номер
36(34)
Опубликована: Сен. 22, 2023
Additive
manufacturing
(AM),
which
is
based
on
the
principle
of
layer-by-layer
shaping
and
stacking
discrete
materials,
has
shown
significant
benefits
in
fabrication
complicated
implants
for
tissue
engineering
(TE).
However,
many
native
tissues
exhibit
anisotropic
heterogenous
constructs
with
diverse
components
functions.
Consequently,
replication
biomimetic
using
conventional
AM
processes
a
single
material
challenging.
Multimaterial
3D
4D
bioprinting
(with
time
as
fourth
dimension)
emerged
promising
solution
constructing
multifunctional
that
can
mimic
host
microenvironment
better
than
single-material
alternatives.
Notably,
4D-printed
multimaterial
architectures
provide
time-dependent
programmable
dynamic
promote
cell
activity
regeneration
response
to
external
stimuli.
This
paper
first
presents
typical
design
strategies
TE
applications.
Subsequently,
latest
are
discussed,
along
their
advantages
challenges.
In
particular,
potential
smart
highlighted.
Furthermore,
this
review
provides
insights
into
how
facilitate
realization
next-generation
Advanced Materials,
Год журнала:
2024,
Номер
36(30)
Опубликована: Апрель 20, 2024
Abstract
Addressing
large
bone
defects
remains
a
significant
challenge
owing
to
the
inherent
limitations
in
self‐healing
capabilities,
resulting
prolonged
recovery
and
suboptimal
regeneration.
Although
current
clinical
solutions
are
available,
they
have
notable
shortcomings,
necessitating
more
efficacious
approaches
Organoids
derived
from
stem
cells
show
great
potential
this
field;
however,
development
of
organoids
has
been
hindered
by
specific
demands,
including
need
for
robust
mechanical
support
provided
scaffolds
hybrid
extracellular
matrices
(ECM).
In
context,
bioprinting
technologies
emerged
as
powerful
means
replicating
complex
architecture
tissue.
The
research
focused
on
fabrication
highly
intricate
ECM
analog
using
novel
bioink
composed
gelatin
methacrylate/alginate
methacrylate/hydroxyapatite
(GelMA/AlgMA/HAP).
Bioprinted
facilitate
long‐term
cultivation
progressive
maturation
extensive
bioprinted
organoids,
foster
multicellular
differentiation,
offer
valuable
insights
into
initial
stages
formation.
intrinsic
self‐mineralizing
quality
closely
emulates
properties
natural
bone,
empowering
with
enhanced
repair
both
vitro
vivo
applications.
This
trailblazing
investigation
propels
field
tissue
engineering
holds
promise
its
translation
practical
Advanced Materials,
Год журнала:
2024,
Номер
36(34)
Опубликована: Июнь 11, 2024
The
repair
and
functional
reconstruction
of
bone
defects
resulting
from
severe
trauma,
surgical
resection,
degenerative
disease,
congenital
malformation
pose
significant
clinical
challenges.
Bone
tissue
engineering
(BTE)
holds
immense
potential
in
treating
these
defects,
without
incurring
prevalent
complications
associated
with
conventional
autologous
or
allogeneic
grafts.
3D
printing
technology
enables
control
over
architectural
structures
at
multiple
length
scales
has
been
extensively
employed
to
process
biomimetic
scaffolds
for
BTE.
In
contrast
inert
grafts,
next-generation
smart
possess
a
remarkable
ability
mimic
the
dynamic
nature
native
extracellular
matrix
(ECM),
thereby
facilitating
regeneration.
Additionally,
they
can
generate
tailored
controllable
therapeutic
effects,
such
as
antibacterial
antitumor
properties,
response
exogenous
and/or
endogenous
stimuli.
This
review
provides
comprehensive
assessment
progress
3D-printed
BTE
applications.
It
begins
an
introduction
physiology,
followed
by
overview
technologies
utilized
scaffolds.
Notable
advances
various
stimuli-responsive
strategies,
efficacy,
applications
are
discussed.
Finally,
highlights
existing
challenges
development
implementation
scaffolds,
well
emerging
this
field.
Bioactive Materials,
Год журнала:
2024,
Номер
40, С. 597 - 623
Опубликована: Авг. 15, 2024
Tissue
engineering
technology
has
advanced
rapidly
in
recent
years,
offering
opportunities
to
construct
biologically
active
tissues
or
organ
substitutes
repair
even
enhance
the
functions
of
diseased
and
organs.
Tissue-engineered
scaffolds
rebuild
extracellular
microenvironment
by
mimicking
matrix.
Fibrin-based
possess
numerous
advantages,
including
hemostasis,
high
biocompatibility,
good
degradability.
Fibrin
provide
an
initial
matrix
that
facilitates
cell
migration,
differentiation,
proliferation,
adhesion,
also
play
a
critical
role
cell-matrix
interactions.
are
now
widely
recognized
as
key
component
tissue
engineering,
where
they
can
facilitate
defect
repair.
This
review
introduces
properties
fibrin,
its
composition,
structure,
biology.
In
addition,
modification
cross-linking
modes
fibrin
discussed,
along
with
various
forms
commonly
used
engineering.
We
describe
biofunctionalization
fibrin.
provides
detailed
overview
use
applications
skin,
bone,
nervous
tissues,
novel
insights
into
future
research
directions
for
clinical
treatment.
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(8), С. 5082 - 5106
Опубликована: Июль 15, 2024
In
view
of
their
exceptional
approach,
excellent
inherent
biocompatibility
and
biodegradability
properties,
interaction
with
the
local
extracellular
matrix,
protein-based
polymers
have
received
attention
in
bone
tissue
engineering,
which
is
a
multidisciplinary
field
that
repairs
regenerates
fractured
bones.
Bone
multihierarchical
complex
structure,
it
performs
several
essential
biofunctions,
including
maintaining
mineral
balance
structural
support
protecting
soft
organs.
Protein-based
gained
interest
developing
ideal
scaffolds
as
emerging
biomaterials
for
healing
regeneration,
challenging
to
design
substitutes
perfect
biomaterials.
Several
polymers,
collagen,
keratin,
gelatin,
serum
albumin,
etc.,
are
potential
materials
due
cytocompatibility,
controlled
biodegradability,
high
biofunctionalization,
tunable
mechanical
characteristics.
While
numerous
studies
indicated
encouraging
possibilities
proteins
BTE,
there
still
major
challenges
concerning
stability
physiological
conditions,
continuous
release
growth
factors
bioactive
molecules.
Robust
derived
from
can
be
used
replace
broken
or
diseased
biocompatible
substitute;
proteins,
being
biopolymers,
provide
engineering.
Herein,
recent
developments
protein
cutting-edge
engineering
addressed
this
review
within
3–5
years,
focus
on
significant
future
perspectives.
The
first
section
discusses
fundamentals
anatomy
scaffolds,
second
describes
fabrication
techniques
scaffolds.
third
highlights
importance
applications
BTE.
Hence,
development
state-of-the-art
has
been
discussed,
highlighting
Biomaterials Science,
Год журнала:
2024,
Номер
12(5), С. 1079 - 1114
Опубликована: Янв. 1, 2024
Hydrogels,
formed
from
crosslinked
hydrophilic
macromolecules,
provide
a
three-dimensional
microenvironment
that
mimics
the
extracellular
matrix.
They
served
as
scaffold
materials
in
regenerative
medicine
with
an
ever-growing
demand.
However,
hydrogels
composed
of
only
organic
components
may
not
fully
meet
performance
and
functionalization
requirements
for
various
tissue
defects.
Composite
hydrogels,
containing
inorganic
components,
have
attracted
tremendous
attention
due
to
their
unique
compositions
properties.
Rigid
particles,
rods,
fibers,
ACS Omega,
Год журнала:
2025,
Номер
10(1), С. 230 - 238
Опубликована: Янв. 1, 2025
In
bone
tissue
engineering,
a
suitable
scaffold
is
the
key.
Due
to
their
similar
composition
tissue,
special
structure,
good
mechanical
properties,
and
osteogenic
acellular
fish
scale
scaffolds
are
potential
for
engineering.
At
present,
decellularization
scheme
mostly
uses
combination
of
sodium
dodecyl
sulfate
ethylenediamine
tetraacetic
acid
(EDTA),
but
this
method
has
problems.
We
optimized
using
combined
Triton
X-100,
EDTA,
nuclease.
study,
optimal
was
screened
with
respect
effect,
extracellular
matrix
structure
retention,
cell
biocompatibility,
differentiation
ability.
The
results
showed
that
as
follows:
native
scales
were
incubated
in
0.1%
EDTA
24
h,
then
cellular
components
removed
1%
X-100
4
days,
followed
by
nuclease
digestion
h.
On
basis,
we
proposed
novel
more
scheme,
prepared
may
have
great