International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(20), С. 15058 - 15058
Опубликована: Окт. 11, 2023
OPMDs
(oral
potentially
malignant
disorders)
are
a
group
of
disorders
affecting
the
oral
mucosa
that
characterized
by
aberrant
cell
proliferation
and
higher
risk
transformation.
Vitamin
D
(VitD)
its
receptor
(VDR)
have
been
extensively
studied
for
their
potential
contributions
to
prevention
therapeutic
management
various
diseases
neoplastic
conditions,
including
cancer.
Observational
studies
suggest
correlations
between
VitD
deficiency
cancer
risk,
worse
prognosis,
increased
mortality
rates.
Interestingly,
emerging
data
also
link
insufficiency
onset
or
progression
OPMDs.
Understanding
role
VitD–VDR
axis
not
only
in
established
tumors
but
might
thus
enable
early
detection
With
this
article,
we
want
provide
an
overview
current
knowledge
about
investigate
association
ramifications
clinical
Applied Microbiology and Biotechnology,
Год журнала:
2024,
Номер
108(1)
Опубликована: Июль 6, 2024
Abstract
Vitamin
D
deficiencies
are
linked
to
multiple
human
diseases.
Optimizing
its
synthesis,
physicochemical
properties,
and
delivery
systems
while
minimizing
side
effects
is
of
clinical
relevance
great
medical
industrial
interest.
Biotechnological
techniques
may
render
new
modified
forms
vitamin
that
exhibit
improved
absorption,
stability,
or
targeted
physiological
effects.
Novel
derivatives
hold
promise
for
developing
future
therapeutic
approaches
addressing
specific
health
concerns
related
deficiency
impaired
metabolism,
such
as
avoiding
hypercalcemic
Identifying
engineering
key
enzymes
biosynthetic
pathways
involved,
well
efficient
cultures,
therefore
outmost
importance
subject
intense
research.
Moreover,
we
elaborate
on
the
critical
role
microbial
bioconversions
might
play
in
a
la
carte
design,
production
novel,
more
efficient,
safer
analogs.
In
summary,
novelty
this
work
resides
detailed
description
physiological,
medical,
biochemical,
epidemiological
aspects
supplementation
steps
towards
enhanced
simplified
family
bioactives
relying
enzymes.
Key
points
•
Liver
kidney
pathologies
hamper
biosynthesis
Actinomycetes
able
carry
out
1α-
25-hydroxylation
precursors
OPMDs
(Oral
Potentially
Malignant
Disorders)
are
a
group
of
disorders
affecting
the
oral
mucosa
that
characterized
by
aberrant
cell
proliferation
and
higher
risk
malignant
transformation.
Vitamin
D
(VitD)
its
receptor
(VDR)
have
been
extensively
studied
for
their
potential
contributions
to
prevention
therapeutic
management
range
diseases
neoplastic
conditions,
including
cancer.
Observational
studies
suggest
correlations
between
VitD
deficiency
cancer
risk,
worse
prognosis,
increased
mortality
rates.
Interestingly,
emerging
data
also
reveals
link
insufficiency
onset
or
progression
OPMDs.
Understanding
role
VitD-VDR
axis
not
only
in
established
tumors
but
might
thus
enable
early
detection
With
this
article,
we
want
provide
an
overview
current
knowledge
about
VitD,
investigate
association
ramifications
clinical
Quality in Sport,
Год журнала:
2024,
Номер
15, С. 52009 - 52009
Опубликована: Июль 5, 2024
Introduction:
Vitamin
D
plays
a
very
important
role
in
the
human
body.
It
affects
bone
health,
immune
system
function,
and
is
responsible
for
overall
well-being.
deficiency
common
worldwide.
contributes
to
development
of
osteoporosis,
cardiovascular
diseases,
autoimmune
disorders
many
others.
This
article
reviews
current
state
knowledge
about
vitamin
deficiency,
its
causes,
health
consequences,
diagnostic
methods,
treatment
options,
with
particular
focus
on
effectiveness
calcifediol
treating
this
deficiency.
Aim
Study:
The
aim
study
was
summarize
D,
causes
efficacy
calcifediol.
Materials
Methods:
literature
available
PubMed
database
reviewed
using
following
keywords:
"vitamin
deficiency",
"calcifediol
treatment",
metabolism",
"epidemiology
criteria",
"calcifediol".
Conclusions:
an
maintaining
supporting
regulating
various
physiological
processes.
However,
despite
importance,
widespread,
affecting
populations
around
world
due
factors
such
as
limited
sun
exposure,
dietary
habits
certain
conditions.
Calcifediol
has
become
particularly
effective
higher
bioavailability
faster
performance
compared
other
forms,
cholecalciferol.
Bone Reports,
Год журнала:
2024,
Номер
22, С. 101796 - 101796
Опубликована: Июль 27, 2024
Treatment
of
calcium
(Ca)
and
vitamin
D
(VD)
deficiency
(VDD)
is
crucial
for
health,
especially
in
bone
conditions,
such
as
low
mineral
density
(BMD)
osteoporosis.
Despite
updates
clinical
guideline
recommendations,
no
studies
have
evaluated
the
efficacy
safety
administering
2000
IU
cholecalciferol
combined
with
calcium.
Thus,
main
objective
this
study
was
to
evaluate
VD
levels
following
treatment
Ca
600
mg/
real-life
practice.
Nutrients,
Год журнала:
2024,
Номер
16(23), С. 3974 - 3974
Опубликована: Ноя. 21, 2024
There
is
currently
a
growing
awareness
that
nutritional
factors
have
major
impacts
on
the
risk
of
age-associated
chronic
non-communicable
diseases
and
mortality
[...].
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(20), С. 15058 - 15058
Опубликована: Окт. 11, 2023
OPMDs
(oral
potentially
malignant
disorders)
are
a
group
of
disorders
affecting
the
oral
mucosa
that
characterized
by
aberrant
cell
proliferation
and
higher
risk
transformation.
Vitamin
D
(VitD)
its
receptor
(VDR)
have
been
extensively
studied
for
their
potential
contributions
to
prevention
therapeutic
management
various
diseases
neoplastic
conditions,
including
cancer.
Observational
studies
suggest
correlations
between
VitD
deficiency
cancer
risk,
worse
prognosis,
increased
mortality
rates.
Interestingly,
emerging
data
also
link
insufficiency
onset
or
progression
OPMDs.
Understanding
role
VitD–VDR
axis
not
only
in
established
tumors
but
might
thus
enable
early
detection
With
this
article,
we
want
provide
an
overview
current
knowledge
about
investigate
association
ramifications
clinical
