Effects of exercise or metformin on myokine concentrations in patients with breast and colorectal cancer: A phase II multi‐centre factorial randomized trial

Journal of Cachexia Sarcopenia and Muscle, Год журнала: 2024, Номер 15(4), С. 1520 - 1527

Опубликована: Июнь 18, 2024

Physical activity and metformin pharmacotherapy are associated with improved clinical outcomes in breast colorectal cancer survivors. Myokines cytokines secreted from skeletal muscle that may mediate these associations.

Язык: Английский

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Unlocking the potential of exercise: harnessing myokines to delay musculoskeletal aging and improve cognitive health

Frontiers in Physiology, Год журнала: 2024, Номер 15

Опубликована: Сен. 2, 2024

Objectives This review aims to summarize the common physiological mechanisms associated with both mild cognitive impairment (MCI) and musculoskeletal aging while also examining relevant literature on how exercise regulation influences levels of shared myokines in these conditions. Methods The search was conducted via databases such as PubMed (including MEDLINE), EMBASE, Cochrane Library Systematic Reviews. searches were limited full-text articles published English, most recent 16 July 2024. inclusion criteria for this focused role delaying enhancing health. Newcastle‒Ottawa Scale (NOS) utilized assess quality nonrandomized studies, only those studies moderate high scores, per criteria, included final analysis. Data analysis performed through narrative synthesis. Results primary outcome study evaluation myokine expression, which IL-6, IGF-1, BDNF, CTSB, irisin, LIF. A total involving 633 older adults met criteria. current modalities primarily consisted resistance training moderate-to high-intensity cardiovascular exercise. types interventions treadmill training, elastic band aquatic Nordic walking training. results indicated that could delay enhance functions brain. Additionally, different intensities exhibited varying effects expression. Conclusion Current evidence suggests mediates secretion specific myokines, including LIF, establish self-regulatory circuits between brain muscle. interaction enhances function improves skeletal muscle function. Future research should focus elucidating exact govern release correlation intensity distinct processes by influence

Язык: Английский

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Effects of short- and long-term exercise training on cancer cells in vitro: Insights into the mechanistic associations

Journal of sport and health science/Journal of Sport and Health Science, Год журнала: 2024, Номер 14, С. 100994 - 100994

Опубликована: Окт. 5, 2024

Exercise is a therapeutic approach in cancer treatment, providing several benefits. Moreover, exercise associated with reduced risk for developing range of cancers and their recurrence, as well improving survival, even though the underlying mechanisms remain unclear. Preclinical clinical evidence shows that acute effects single session can suppress growth various cell lines vitro. This suppression potentially due to altered concentrations hormones (e.g., insulin) cytokines tumor necrosis factor alpha interleukin 6) after exercise. These factors, known be involved tumorigenesis, may explain why incidence, mortality. However, short- (<8 weeks) long-term (≥8 programs on cells have been reported mixed results. Although more research needed, it appears interventions incorporating both diet seem greater inhibitory apparently healthy subjects patients. speculative, these suppressive driven by changes body weight composition reduction low-grade inflammation often sedentary behavior, low muscle mass, excess fat mass Taken together, such could alter systemic levels circulating leading less favorable environment tumorigenesis. While regular establish cancer-suppressive environment, each bout provides further "dose" anticancer medicine. Therefore, integrating play significant role management, highlighting need future investigations this promising area research.

Язык: Английский

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MG53 Deficiency Mediated Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease Via Impairing Mitochondrial Dynamics

Опубликована: Янв. 1, 2025

Язык: Английский

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The mediating role of behavioral systems in linking physical activity and anxiety symptoms in college students

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 25, 2025

Data show that the detection rate of anxiety symptoms among college students has risen from 16.6 to 34.8% over past 10 years, and are gradually becoming a high prevalence group for symptoms.This study aims investigate relationship between physical activity, behavioral inhibition activation, in students. Specifically, it seeks identify mediating role individual subcomponents activation association activity symptoms. A total 5125 were recruited participate study. Participants completed Physical Activity Rating Scale-3, Behavioral Inhibition/Activation System Scale, Generalized Anxiety Disorder-7 (GAD-7) scale. ANOVA, linear regression analysis structural equation modelling used analyse data each variable (physical symptoms, BIS/BAS) analysed. Anxious demonstrated significantly lower scores reward responsiveness, drive, fun seeking, while exhibiting higher inhibition. Additionally, these engaged at intensities, shorter times, with reduced frequency, overall less exercise (all p < 0.001). Furthermore, significant negative correlation was observed levels (r= − 0.145, 0.001), weak identified system 0.020, = 0.156). Conversely, positively correlated responsiveness (r 0.062, drive 0.122, seeking 0.067, inhibition, predictors university Among male students, intensity (Beta= 0.088, 0.001) 0.255, showed strongest correlations levels, female time (Beta 0.084, 0.291, most highly correlated. had direct effect 84.37% on reducing 0.286, 15.63% mediated by 0.053, The effects stronger females (29.92%, Beta= 0.076, compared males (15.76%, 0.061, Factor loadings indicated (male: 1.81, female: 2.71) 1.01, 1.04) more effective alleviating particularly dimensions uncontrollable worrying (1.07), worry too much (1.03), trouble relaxing (1.00), nervousness (1.00). exerts influence anxiety, its anxiolytic partially system. This is pronounced student population.

Язык: Английский

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The role of irisin in exercise-induced muscle and metabolic health: a narrative review

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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The role of resistance exercise-induced local metabolic stress in mediating systemic health and functional adaptations: could condensed training volume unlock greater benefits beyond time efficiency?

Frontiers in Physiology, Год журнала: 2025, Номер 16

Опубликована: Апрель 17, 2025

The majority of “specialised” exercise configurations (e.g., supersets, drop sets, blood flow restriction) are being assessed as “shortcuts” to hypertrophy and strength improvements. However, these advanced training techniques may also offer significant benefits for systemic health functional outcomes across recreational clinical populations via locally induced metabolic responses. Stress-regulating mechanisms known enhance the body’s resilience by facilitating allostasis, process coordinating adaptive processes in reaction stressors such physical training. Yet, role local stress provoked resistance has not gained much research attention despite its wide potential. Positive effects only linked improved muscular endurance, primary secondary mechanisms, but release myokines, hormones, microRNAs, immune factors, inflammatory substances other endocrine molecules that initiate numerous health-promoting modifications on a level. Resistance strategies maximise accumulation metabolites well defined, although high volume, close proximity failure shorter rests seem be necessity. Additionally, restriction provides potent alternative inducing acidosis, thereby triggering several pathways associated with immunity function even remote muscle tissues. Future is warranted further explore techniques, approaches comparable mental those seen forms high-intensity interval heavy

Язык: Английский

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Effect of 6-week single leg countermovement jump training on force time metrics in elite female youth footballers

Journal of Sports Sciences, Год журнала: 2025, Номер unknown, С. 1 - 11

Опубликована: Апрель 18, 2025

Female football participation has grown exponentially. Unfortunately, females exhibit greater injury risk than male athletes, and experience increased mechanical stress during adolescence. Force plates provide accurate reliable force-time characteristics enabling profiling of benchmarking using a variety jump isometric tasks. The purpose this study was to determine whether test-retest reliability SLCMJ, bilateral countermovement (CMJ), rebound (CMJ-R) mid-thigh pull (IMTP) change with six weeks SLCMJ training. Twenty-eight elite youth female footballers (13.7 ± 1.1 years, 53.27 8.82 kg, 162.20 5.37 cm) completed as part routine strength plyometric training program. did not influence resulted in favourable adaptations indicated through small large changes for SLCMJ. Significant (p < 0.05) yet trivial were observed the CMJ CMJ-R, increases IMTP. results demonstrate that does phase-specific test-rest (i.e. braking propulsion) causes weekly fluctuations leading improvements CMJ, CMJ-R Practitioners can use such information inform design monitor athlete performance.

Язык: Английский

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The Role of Cardiac Troponin and Other Emerging Biomarkers Among Athletes and Beyond: Underlying Mechanisms, Differential Diagnosis, and Guide for Interpretation

Biomolecules, Год журнала: 2024, Номер 14(12), С. 1630 - 1630

Опубликована: Дек. 19, 2024

Cardiovascular (CV) disease remains the leading cause of morbidity and mortality worldwide, highlighting necessity understanding its underlying molecular pathophysiological pathways. Conversely, physical activity (PA) exercise are key strategies in reducing CV event risks. Detecting latent conditions apparently healthy individuals, such as athletes, presents a unique challenge. The early identification treatment disorders vital for long-term health patient survival. Cardiac troponin is currently most commonly used biomarker assessing changes both athletes general population. However, there considerable debate surrounding mechanisms exercise-induced elevations release non-ischemic contexts. Thus, pressing need to identify implement more sensitive specific biomarkers clinical practice. Indeed, research continues explore reliable evaluating effectiveness exercise. It essential analyze current evidence on conditions, post-strenuous exercise, complex biological pathways that influence detection. Furthermore, this study summarizes cytokines exosomes, including their physiological roles relevance various especially athletes. In addition, paper gives special attention mechanisms, potential biomarkers, future perspectives.

Язык: Английский

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Exerkine response to acute exercise: Still much to discover

Journal of sport and health science/Journal of Sport and Health Science, Год журнала: 2024, Номер 13(6), С. 759 - 760

Опубликована: Апрель 12, 2024

• Exerkines mediate, at least partly, the salutary effects of exercise. However, actual responsiveness and time-course profile most these molecules remains unknown. Future research should explore potential factors explaining inter-individual variability in exerkine responses.

Язык: Английский

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