Scientific Reports,
Год журнала:
2023,
Номер
13(1)
Опубликована: Июль 14, 2023
The
present
study
attempts
to
treat
S.
aureus-induced
soft
skin
infections
using
a
combinatorial
therapy
with
an
antibiotic,
Ciprofloxacin
(CIP),
and
efflux
pump
inhibitor
5-Nitro-2-(3-phenylpropoxy)
pyridine
(5-NPPP)
through
smart
hydrogel
delivery
system.
aims
reduce
the
increasing
rates
of
antimicrobial
resistance;
therefore,
molecule
is
synthesized
delivered
along
antibiotic
re-sensitize
pathogen
towards
antibiotics
infections.
CIP-loaded
polyvinyl
alcohol
(PVA)
hydrogels
at
varying
concentrations
were
fabricated
optimized
by
chemical
cross-linking
process,
which
exhibited
sustained
drug
release
for
5
days.
compound
5-NPPP
loaded
provided
linear
2
days,
necessitating
need
development
polymeric
nanoparticles
alter
pattern.
Eudragit
RSPO
prepared
modified
nanoprecipitation-solvent
evaporation
method,
showed
optimum
average
particle
size
230-280
nm
>
90%
entrapment
efficiency.
PVA
provide
predetermined
synergistic
effect.
selected
7%
dual
drugs
evaluated
Balb/c
mice
models
induced
aureus
results
in
vivo
studies
evidence
that
non-toxic
reduced
bacterial
load
causing
re-sensitization
antibiotics,
could
initiate
re-epithelization.
research
concluded
CIP
be
ideal
promising
system
treating
JACS Au,
Год журнала:
2024,
Номер
4(10), С. 3744 - 3758
Опубликована: Окт. 3, 2024
Eutectogels,
a
rising
category
of
soft
materials,
have
recently
garnered
significant
attention
owing
to
their
remarkable
potential
in
various
domains.
This
innovative
class
materials
consists
eutectic
solvent
immobilized
three-dimensional
network
structure.
The
use
eco-friendly
and
cost-effective
solvents
further
emphasizes
the
appeal
these
multiple
applications.
Eutectogels
exhibit
key
characteristics
most
solvents,
including
environmental
friendliness,
facile
preparation,
low
vapor
pressure,
good
ionic
conductivity.
Moreover,
they
can
be
tailored
display
functionalities
such
as
self-healing
capability,
adhesiveness,
antibacterial
properties,
which
are
facilitated
by
incorporating
specific
combinations
mixture
constituents.
perspective
article
delves
into
current
landscape
challenges
associated
with
eutectogels,
particularly
focusing
on
applications
CO
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials,
Год журнала:
2024,
Номер
158, С. 106674 - 106674
Saudi Pharmaceutical Journal,
Год журнала:
2023,
Номер
31(10), С. 101749 - 101749
Опубликована: Авг. 18, 2023
Wound
healing
is
the
complex
physiological
process
of
replacing
damaged
cells
or
tissue
layers.
The
neem
(Azadirachta
Indica)
has
a
variety
biological
activities,
which
may
hasten
rate
at
wound
mechanism
occurs.
Silk
fibroin
biomaterial
that
reported
for
its
regeneration
activity.
So,
present
study
was
designed
to
assess
effectiveness
hydrogel
comprising
and
silk
biomaterials
treatment
wounds.Topical
hydrogels
(N-HG)
with
without
(N-SFB-HG)
were
prepared
using
extract,
fibroin,
guar
gum,
act
by
entrapping
components
forming
gel.
Evaluation
tests
such
as
Fourier
transform
infrared
spectroscopy
(FT-IR),
visual
emergence,
pH,
rheological
behavior,
spreading
capacity,
drug
content,
skin
irritation,
anti-microbial
action,
in
vivo
activity,
stability
carried
out.The
FT-IR
results
showed
no
chemical
interaction
between
constituents.
formed
had
pH
values
5.87
±
0.3
N-HG
5.76
0.2
N-SFB-HG.
preferred
topical
gel
viscosity
observed
(54.2
3.2cPs)
N-SFB-HG
(59.9
4.8cPs)
formulations.
formulated
sterile
did
not
irritate
skin.
investigation
reveal
N-SF-HG
speeds
up
injured
area
faster
when
compared
control
treated
groups.These
support
efficacy
formulation,
including
fibroin.
Therefore,
neem-silk
formulation
therapeutically
viable
choice
that,
following
necessary
clinical
research,
might
be
utilized
novel
formulations
managing
chronic
wounds.
Drug Design Development and Therapy,
Год журнала:
2025,
Номер
Volume 19, С. 599 - 626
Опубликована: Янв. 1, 2025
Silk
protein,
as
a
natural
polymer
material
with
unique
structures
and
properties,
exhibits
tremendous
potential
in
the
biomedical
field.
Given
limited
production
restricted
properties
of
silk
proteins,
molecular
biotechnology
has
been
extensively
applied
protein
genetic
engineering
to
produce
novel
proteins
specific
properties.
This
review
outlines
roles
major
model
organisms,
such
silkworms
spiders,
production,
provides
detailed
introduction
applications
gene
editing
technologies
(eg,
CRISPR-Cas9),
transgenic
expression
technologies,
synthetic
biology
techniques
engineering.
By
analyzing
factors
influencing
expression,
this
further
elaborates
on
innovative
drug
delivery
systems,
tissue
regenerative
medicine
skin,
bone,
cartilage,
vascular
repair),
well
antibacterial
immune
strategies.
Notably,
modified
expressed
by
demonstrate
significant
advantages
enhancing
bioavailability
promoting
cell
proliferation
differentiation.
In
conclusion,
engineering,
through
continuous
innovations
biotechnology,
provided
an
effective
pathway
for
high-performance
materials.
The
extensive
these
field
have
not
only
expanded
functionality
but
also
offered
new
approaches
address
medical
challenges.
future,
development
will
rely
interdisciplinary
integration
promote
in-depth
research
expansion
industrial
proteins.
Polymers,
Год журнала:
2025,
Номер
17(3), С. 425 - 425
Опубликована: Фев. 6, 2025
Silk
fibroin
(SF)-based
hydrogels
were
prepared
by
the
simple
evaporation
method.
The
outcomes
of
SF-based
assessed
for
consideration
in
terms
practical
and
convenient
use.
Guar
gum
(GG)
sodium
benzoate
(SB)
are
blending
reagents
to
SF
solution
poured
into
petri
dish
make
hydrogels.
After
leaving
mixture
three
days
solidify,
all
peeled
off
characterized.
SF-blend
guar
(SF-GG)
SF-GG-blend
(SF-GG-SB)
could
be
constructed,
but
different
textures
levels
transparency.
SB
affected
solid
texture
resulted
a
higher
water
contact
angle
(WCA)
value
hydrogel
than
SF-GG.
results
from
Fourier
transform
infrared
spectroscopy
(FTIR)
indicated
main
functional
groups
substances
that
contained
Moreover,
some
interactions
between
also
detected.
A
thermogravimetric
analyzer
(TGA)
was
used
determine
decomposition
as
function
temperature.
DTG
thermograms,
which
exhibit
maximum
temperature,
revealed
interaction
forces
SF,
well
their
structure,
reason
thermal
stability
SF-GG-SB
have
tensile
strength
SF-GG
In
conclusion,
appearance,
texture,
hydrophilicity,
stability,
types
concentrations
substances.
This
suggests
properties
designed
adjusted
attain
desirable
fitting
target
applications.
Gels,
Год журнала:
2025,
Номер
11(3), С. 207 - 207
Опубликована: Март 15, 2025
Hydrogels
are
innovative
materials
characterized
by
a
water-swollen,
crosslinked
polymeric
network
capable
of
retaining
substantial
amounts
water
while
maintaining
structural
integrity.
Their
unique
ability
to
swell
or
contract
in
response
environmental
stimuli
makes
them
integral
biomedical
applications,
including
drug
delivery,
tissue
engineering,
and
wound
healing.
Among
these,
“smart”
hydrogels,
sensitive
such
as
pH,
temperature,
light,
showcase
reversible
transitions
between
liquid
semi-solid
states.
Thermoresponsive
exemplified
poly(N-isopropylacrylamide)
(PNIPAM),
particularly
notable
for
their
sensitivity
temperature
changes,
transitioning
near
lower
critical
solution
(LCST)
approximately
32
°C
water.
Structurally,
PNIPAM-based
hydrogels
(PNIPAM-HYDs)
chemically
versatile,
allowing
modifications
that
enhance
biocompatibility
functional
adaptability.
These
properties
enable
application
diverse
therapeutic
areas
cancer
therapy,
phototherapy,
healing,
engineering.
In
this
review,
the
behavior
smart
PNIPAM
explored,
with
an
emphasis
on
synthesis
methods
brief
note
biocompatibility.
Furthermore,
PNIPAM-HYDs
detailed,
along
applications
skin
conditions,
ocular
diseases,
etc.
Various
delivery
routes
patents
highlighting
advancements
also
examined.
Finally,
future
prospects
remain
promising,
ongoing
research
focused
enhancing
stability,
responsiveness,
clinical
applicability.
continued
development
is
expected
revolutionize
technologies,
paving
way
more
efficient
targeted
solutions.
Biomedicines,
Год журнала:
2024,
Номер
12(7), С. 1584 - 1584
Опубликована: Июль 17, 2024
Hyaluronic-acid-
and
silk-fibroin-based
nanofibrous
mats
loaded
with
proanthocyanidins
collagen
peptides
were
fabricated
as
multifunctional
facial
masks
using
electrospinning.
Their
morphology,
hygroscopicity
moisture
retention,
DPPH,
ABTS
free
radical
scavenging
abilities,
cytocompatibility
investigated.
The
results
showed
that
the
dense
uniform,
an
average
diameter
ranging
from
300
to
370
nm.
exhibited
satisfactory
oxidation
resistance,
biocompatibility,
especially
excellent
capacities.
DPPH
activity
was
90%
15
mg/L
nanofibers,
0.005
nanofibers.
protected
fibroblasts
oxidative
stress
damage
induced
by
tert-butyl
hydroperoxide
(t-BHP)
significantly
promoted
their
proliferation.
Compared
traditional
liquid
semi-solid
masks,
prepared
in
this
study
contained
fewer
additives,
which
has
significant
advantages
terms
of
safety.
rapidly
dissolved
within
5
s
after
being
sprayed
water,
facilitated
release
penetration
active
ingredients
for
skincare.
Therefore,
displayed
indicating
promising
translational
potential
providing
a
valuable
reference
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
278, С. 134834 - 134834
Опубликована: Авг. 16, 2024
Silk
fibroin
(SF)
has
received
special
attention
from
the
scientific
community
due
to
its
noteworthy
properties.
Its
unique
chemical
structure
results
in
an
uncommon
combination
of
macroscopically
useful
properties,
yielding
a
strong,
fine
and
flexible
material
which,
addition,
presents
good
biodegradability
better
biocompatibility.
Therefore,
silk
various
formats,
appears
as
ideal
candidate
for
supporting
biomedical
applications.
In
this
review,
we
will
focus
on
hydrogels
obtained
or
with
it,
paying
synthesis
procedures,
characterization
methodologies
Tissue
engineering
drug-delivery
systems
are,
undoubtedly,
two
main
areas
where
find
their
place.
