Mimbar Ilmu,
Год журнала:
2024,
Номер
29(3), С. 401 - 410
Опубликована: Дек. 25, 2024
School
principals
play
a
central
role
in
shaping
the
educational
environment
through
policies
they
implement.
Transformational
leadership
by
school
focuses
on
empowering
teachers,
enhancing
student
motivation,
and
fostering
positive
culture
to
achieve
better
outcomes.
This
study
aims
provide
systematic
literature
review
of
impact
transformational
environment.
The
research
reviews
relevant
articles
published
past
five
years
from
Scopus
ERIC
databases,
using
Preferred
Reporting
Items
for
Systematic
Reviews
Meta-Analysis
(PRISMA)
approach.
findings
this
show
that
majority
junior
high
level,
which
is
considered
critical
transitional
phase
students.
can
improve
teacher
performance
areas
such
as
creativity,
innovation,
self-efficacy,
turn
contribute
learning
Moreover,
successful
strategies
employed
include
creating
conducive
climate,
collaboration
among
strengthening
relationships
with
parents,
culture.
These
conclude
necessity
involving
all
elements
within
create
an
ecosystem
supports
holistic
development
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 21, 2024
Abstract
The
creation
of
functional
hydrogels
with
robust
load‐bearing
capacity
adaptable
to
complex
tissue
regeneration
remains
challenging.
Silk
fibroin
(SF)
is
a
natural
biomaterial
excellent
mechanical
strength
and
cell
adhesion
capacity,
possessing
tremendous
potential
solve
the
aforementioned
dilemma.
biodegradability
biocompatibility
molecular
structure
multiple
modifiable
moieties
provide
opportunities
for
injectability
multifunctionality
hydrogels.
Furthermore,
incorporation
other
polymers
or
active
ingredients
can
improve
basic
properties,
confer
biological
activities
pharmacological
effects,
prerequisites
fulfill
specific
requirements.
Therefore,
SF‐based
are
widely
applied
in
repair
regeneration,
especially
bone,
skin,
nerve,
liver,
myocardium,
cornea,
which
have
effectively
addressed
challenges
scaffolds'
lack
sites,
excessive
degradation,
as
well
efficient,
long‐lasting
antimicrobial
properties.
This
review
outlines
properties
SF,
discusses
types
materials
commonly
used
preparation
their
characteristics,
describes
current
construction
methods
SF
Simultaneously,
recent
advancements
applying
multifunctional
within
tissues
explored,
focus
on
role
repair,
highlighting
mechanism
based
bone
skin.
International Journal of Applied Pharmaceutics,
Год журнала:
2025,
Номер
unknown, С. 250 - 258
Опубликована: Март 7, 2025
Objective:
Disruptions
in
the
wound
healing
process
occur
because
of
two
main
factors
diabetes:
high
blood
sugar
levels
and
chronic
inflammation.
This
study
evaluated
effectiveness
hydrogel
patches
containing
neem
leaf
extract
diabetic
wounds.
Methods:
The
experimental
method
used
a
post-test
control
group
design
that
included
preparation,
phytochemical
screening,
patch
stability
testing,
testing
hyperglycemic
rats
by
observing
size,
histopathology,
TNF-α
TGF-β
cytokine
on
days
7,
14,
21.
Results:
contains
secondary
metabolites
support
anti-inflammatory
wound-healing
activities.
Stability
tests
showed
met
standards
for
organoleptic
properties,
weight
uniformity,
moisture
absorption.
given
NLEHP
(Neem
Leaf
Extract
Hydrogel
Patch)
decrease
area
(0.5±0.1
cm2)
not
significantly
different
from
non-diabetic
with
reduction
(p>0.05)
negative
(1.1±0
(p<0.05).
Histopathological
analysis
skin
thickness
(19.2±1.6
μm)
was
(18.2±0.8
higher
than
(10.7±2.4
significant
increase
(p<0.05)
group,
whereas
groups
non-significant
(p>0.05).
progressively
increased
groups,
unlike
decline
observed
control.
Conclusion:
These
results
indicate
is
an
effective
alternative
therapy.
Ethnobotany Research and Applications,
Год журнала:
2024,
Номер
28
Опубликована: Март 14, 2024
Background:
Dermatological
disorders
(DDs)
are
a
significant
public
health
concern
worldwide
as
they
considerably
affecting
the
quality
of
human
and
problematic
to
cure
due
persistence.
This
study
aimed
census
traditional
medicinal
plants
(TMPs)
used
treat
DDs
in
Tabora
region,
Tanzania.
Methods:
Semi-structured
interviews
were
conducted
collect
information
from
healers
(THs).
The
emphasis
was
on
local
plant
names,
cured
DDs,
parts
used,
preparation,
administration
remedies.
Quantitative
approaches,
including
family
importance
value
(FIV),
species
use
(SUV),
part
(PPV),
Jaccard
index
similarity
(JI),
informant
consensus
factor
(ICF),
calculated
too.
Results:
Sixty-four
TMPs
32
families
recorded
for
treating
14
DDs.
dominant
life
form
Fabaceae
(with
20.3%
all
FIV
3.455)
tree
(50%),
respectively.
preferred
mode
utilisation
route
crushing
(28.1%)
topical
(67.2%),
respectively,
while
leaf
(PPV
=
2.86)
most
utilised
part.
TMP
with
highest
SUV
(0.818)
Bidens
Pilosa
L.
(Asteraceae).
A
number
(42.2%)
wound
healing.
ICF
ringworms
(0.972)
least
sores
(0.924).
maximum
(JI
8.3)
South
Africa.
Conclusion:
exposed
significance
by
THs
region
against
To
offer
an
understanding
each
plant's
anti-infective
role,
investigation
authenticate
therapeutic
potential
is
underway.
suggests
need
create
awareness
among
locals
other
stakeholders
conserving
indigenous
knowledge
country
at
large.
Keywords:
Skin
disorders,
ethnomedicine,
plants,
quantitative
indices,
knowledge,
healing
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Фев. 16, 2024
Abstract
Hemigraphis
alternata
(
H.
),
commonly
known
as
Red
Flame
Ivy,
is
widely
recognized
for
its
wound
healing
capabilities.
However,
the
pharmacologically
active
plant
components
and
their
mechanisms
of
action
in
are
yet
to
be
determined.
This
study
presents
mass
spectrometry-based
global
metabolite
profiling
aqueous
ethanolic
extract
leaves.
The
analysis
identified
2285
metabolites
from
24,203
spectra
obtained
both
positive
negative
polarities.
were
classified
under
ketones,
carboxylic
acids,
primary
aliphatic
amines,
steroids
steroid
derivatives.
We
performed
network
pharmacology
explore
metabolite–protein
interactions
124
human
proteins
targets
metabolites.
Among
these,
several
them
implicated
including
prothrombin
(F2),
alpha-2A
adrenergic
receptor
(ADRA2A)
fibroblast
growth
factor
1
(FGFR1).
Gene
ontology
target
enriched
cellular
functions
related
glucose
metabolic
process,
platelet
activation,
membrane
organization
response
wounding.
Additionally,
pathway
enrichment
revealed
potential
molecular
involved
healing.
Moreover,
in-silico
docking
showed
strong
binding
energy
between
with
protein
(F2
PTPN11).
Furthermore,
key
further
validated
by
multiple
reaction
monitoring-based
targeted
analysis.
Natural Product Research,
Год журнала:
2024,
Номер
unknown, С. 1 - 16
Опубликована: Дек. 3, 2024
Recent
advancements
in
nanogel
formulations
have
significantly
enhanced
the
therapeutic
efficacy
of
herbal
medicines
wound
healing
applications.
This
systematic
review
explores
integration
various
extracts
and
bioactive
compounds
into
nano
gels,
highlighting
their
improved
properties
application.
Key
include
tobacco
stem
nanogels
demonstrating
stability
rapid
contraction,
neem
silk
fibroin
hydrogels
accelerating
regeneration,
curcumin
nanosuspension-based
enhancing
contraction
rates.
Additional
formulations,
such
as
Sansevieria
trifasciata
emodin-based
double
network
hydrogels,
showed
substantial
reductions
size
increased
cell
proliferation.
The
incorporation
like
Bletilla
striata,
curcumin,
calendula,
Hibiscus
rosa-sinensis
further
exhibited
coagulation,
antioxidant
effects,
fibroblast
highlights
promising
future
biomedical
applications,
offering
a
synergistic
approach
that
combines
benefits
traditional
medicine
with
advanced
nanotechnology.
