Scientific Reports,
Год журнала:
2023,
Номер
13(1)
Опубликована: Июль 14, 2023
The
present
study
attempts
to
treat
S.
aureus-induced
soft
skin
infections
using
a
combinatorial
therapy
with
an
antibiotic,
Ciprofloxacin
(CIP),
and
efflux
pump
inhibitor
5-Nitro-2-(3-phenylpropoxy)
pyridine
(5-NPPP)
through
smart
hydrogel
delivery
system.
aims
reduce
the
increasing
rates
of
antimicrobial
resistance;
therefore,
molecule
is
synthesized
delivered
along
antibiotic
re-sensitize
pathogen
towards
antibiotics
infections.
CIP-loaded
polyvinyl
alcohol
(PVA)
hydrogels
at
varying
concentrations
were
fabricated
optimized
by
chemical
cross-linking
process,
which
exhibited
sustained
drug
release
for
5
days.
compound
5-NPPP
loaded
provided
linear
2
days,
necessitating
need
development
polymeric
nanoparticles
alter
pattern.
Eudragit
RSPO
prepared
modified
nanoprecipitation-solvent
evaporation
method,
showed
optimum
average
particle
size
230-280
nm
>
90%
entrapment
efficiency.
PVA
provide
predetermined
synergistic
effect.
selected
7%
dual
drugs
evaluated
Balb/c
mice
models
induced
aureus
results
in
vivo
studies
evidence
that
non-toxic
reduced
bacterial
load
causing
re-sensitization
antibiotics,
could
initiate
re-epithelization.
research
concluded
CIP
be
ideal
promising
system
treating
Current Pharmaceutical Design,
Год журнала:
2024,
Номер
30(32), С. 2550 - 2561
Опубликована: Июль 25, 2024
Psoriasis
(Pso)
is
an
autoimmune
inflammatory
skin
disease
characterized
by
red
plaques
covered
in
silver
scales.
The
existing
treatments
provide
limited
benefits
and
are
associated
with
certain
drawbacks
which
limit
their
use.
Thus,
there
a
need
to
explore
more
options
that
highly
target-specific
minimal
side
effects.
Researchers
have
thoroughly
investigated
the
use
of
herbal
drugs
for
therapeutic
potential.
Preclinical
studies
demonstrate
phytochemicals
such
as
curcumin,
psoralen,
dithranol
antipsoriatic
These
phytoconstituents
inhibit
signalling
pathways,
interleukin
(IL)
23/Th17
axis
IL-36
loop
involved
pathogenesis
Pso.
down-regulate
pro-inflammatory
cytokines
like
IL-17
tumor
necrosis
factor
(TNF)-α.
However,
application
clinical
settings
due
poor
bioavailability
access
target
sites.
Combining
modern
delivery
platforms
nanocarriers
can
address
these
shortcomings
improve
efficacy.
This
review
explores
potential
remedies
substitute
conventional
therapies,
emphasizing
trials
conducted
medicines.
paper
supported
discussion
on
liposomes,
niosomes,
emulsomes,
ethosomes,
nanostructured
lipid
carriers,
nanoemulsions,
dendrimers
used
deliver
ABSTRACT
Potential
therapies
for
wound
management
remain
one
of
the
most
challenging
affairs
to
date.
Biopolymer
hydrogels
possess
inherent
properties
that
facilitate
healing
damaged
tissue
by
creating
a
supportive
and
hydrated
environment.
Chitosan/fibroin
were
formulated
with
poly
(vinyl
pyrrolidone)
cross‐linked
using
3‐aminopropyl
(diethoxy)
methylsilane
(APDEMS)
aforementioned
function.
The
characterized
through
Fourier
transform
infrared
spectroscopy,
thermogravimetric
analysis,
scanning
electron
microscopy,
their
swelling
response
was
observed
variety
solvents.
Additionally,
investigated
biomedical
applications.
As
amount
fibroin
added
increased,
ratio
decreased.
analysis
chorioallantoic
membrane
(CAM)
assay
revealed
higher
concentrations
in
hydrogel
directly
correlated
increased
angiogenesis.
intragroup
comparison
showed
vascular
number
CPF5
group
significantly
(
p
≤
0.05)
compared
other
groups.
efficiency
prepared
rate
reduction
(99.06%)
remarkably
high
greater
content
against
control
(67.03%).
Histological
findings
wounded
tissues
corroborate
abovementioned
results,
showing
dense
fibrous
connective
control.
results
this
work
provide
thorough
preclinical
evidence
chitosan‐fibroin
biopolymers
are
involved
enhanced
angiogenesis
growing
chicks
speed
up
mice
without
any
obvious
toxicity.
Molecular Pharmaceutics,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 29, 2024
Phytochemicals,
which
are
predominantly
found
in
plants,
hold
substantial
medicinal
value.
Despite
their
potential,
challenges
such
as
poor
oral
bioavailability
and
instability
the
gastrointestinal
tract
have
limited
therapeutic
use.
Traditional
intra/transdermal
drug
delivery
systems
offer
some
advantages
over
administration
but
still
suffer
from
issues
penetration
depth,
slow
release
rates,
inconsistent
absorption.
In
contrast,
microneedles
(MNs)
represent
a
significant
advancement
by
providing
precise
control
phytochemical
enhanced
capabilities.
By
circumventing
skin
barriers,
MNs
directly
access
dermal
layers
rich
blood
vessels
lymphatics,
thus
facilitating
efficient
delivery.
This
review
extensively
discusses
obstacles
of
traditional
benefits
routes
with
particular
focus
on
transformative
potential
for
explores
complexities
delivering
phytochemicals
through
routes,
development
types
innovative
tools,
optimal
design
properties
effective
Additionally,
this
examines
versatile
applications
MN-mediated
delivery,
including
its
role
administering
phytophotosensitizers
photodynamic
therapy,
concludes
insights
into
relevant
patents
future
perspectives.
Scientific Reports,
Год журнала:
2023,
Номер
13(1)
Опубликована: Июль 14, 2023
The
present
study
attempts
to
treat
S.
aureus-induced
soft
skin
infections
using
a
combinatorial
therapy
with
an
antibiotic,
Ciprofloxacin
(CIP),
and
efflux
pump
inhibitor
5-Nitro-2-(3-phenylpropoxy)
pyridine
(5-NPPP)
through
smart
hydrogel
delivery
system.
aims
reduce
the
increasing
rates
of
antimicrobial
resistance;
therefore,
molecule
is
synthesized
delivered
along
antibiotic
re-sensitize
pathogen
towards
antibiotics
infections.
CIP-loaded
polyvinyl
alcohol
(PVA)
hydrogels
at
varying
concentrations
were
fabricated
optimized
by
chemical
cross-linking
process,
which
exhibited
sustained
drug
release
for
5
days.
compound
5-NPPP
loaded
provided
linear
2
days,
necessitating
need
development
polymeric
nanoparticles
alter
pattern.
Eudragit
RSPO
prepared
modified
nanoprecipitation-solvent
evaporation
method,
showed
optimum
average
particle
size
230-280
nm
>
90%
entrapment
efficiency.
PVA
provide
predetermined
synergistic
effect.
selected
7%
dual
drugs
evaluated
Balb/c
mice
models
induced
aureus
results
in
vivo
studies
evidence
that
non-toxic
reduced
bacterial
load
causing
re-sensitization
antibiotics,
could
initiate
re-epithelization.
research
concluded
CIP
be
ideal
promising
system
treating
