Chronic kidney disease

Nature Reviews Disease Primers, Год журнала: 2025, Номер 11(1)

Опубликована: Янв. 30, 2025

Язык: Английский

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Kidney fibrosis: Emerging diagnostic and therapeutic strategies

Molecular Aspects of Medicine, Год журнала: 2023, Номер 93, С. 101206 - 101206

Опубликована: Авг. 3, 2023

Язык: Английский

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Polyploid tubular cells: a shortcut to stress adaptation

Kidney International, Год журнала: 2024, Номер 105(4), С. 709 - 716

Опубликована: Янв. 9, 2024

Tubular epithelial cells (TC) compose the majority of kidney parenchyma and play fundamental roles in maintaining homeostasis. Like other tissues, mostly immature TC with progenitor capabilities are able to replace lost during injury via clonal expansion differentiation. In contrast, differentiated lack this capacity. However, as is frequently exposed toxic injuries, evolution positively selected a response program that endows maintain residual function injury. Recently, we others have described polyploidization TC, mechanism augment remnant after an by rapid hypertrophy. Polyploidy condition characterized more than two complete sets chromosomes. Polyploid often display increased functional capacity generally resilient stress evidenced being conserved across many plants eukaryote species from flies mammals. Here, discuss occurrence polyploidy different contexts conditions how integrates into existing concepts cell responses Collectively, aim at stimulating acquisition novel knowledge field well accelerating translation basic clinical sphere.

Язык: Английский

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Cell death‑related molecules and targets in the progression of urolithiasis (Review)

International Journal of Molecular Medicine, Год журнала: 2024, Номер 53(6)

Опубликована: Апрель 22, 2024

Urolithiasis is a high‑incidence disease caused by calcium oxalate (mainly), uric acid, phosphate, struvite, apatite, cystine and other stones. The development of kidney stones closely related to renal tubule cell damage crystal adhesion aggregation. Cell death, comprising the core steps damage, can be classified into various types (i.e., apoptosis, ferroptosis, necroptosis pyroptosis). Different types, concentrations, morphologies sizes cause tubular via regulation different forms death. Oxidative stress high or concentrations considered precursor variety In addition, complex crosstalk exists among numerous signaling pathways their key molecules in metabolic disorder, tricarboxylic acid cycle‑related molecules, such as citrate succinate, are death inhibition stone development. However, literature review associations between development, metabolism currently lacking, at least best our knowledge. Thus, present summarizes major advances understanding regulated urolithiasis progression.

Язык: Английский

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CKD therapy to improve outcomes of immune-mediated glomerular diseases

Nephrology Dialysis Transplantation, Год журнала: 2023, Номер 38(Supplement_2), С. ii50 - ii57

Опубликована: Май 22, 2023

ABSTRACT The management of immunoglobulin A nephropathy, membranous lupus nephritis, anti-neutrophil cytoplasmic antibody–associated vasculitis, C3 glomerulonephritis, autoimmune podocytopathies and other immune-mediated glomerular disorders is focused on two major treatment goals, preventing overall mortality the loss kidney function. Since minimizing irreversible damage best serves both must focus central pathomechanisms function decline, i.e., controlling underlying immune disease process (e.g. with immunotherapies) non-immune mechanisms chronic (CKD) progression. Here we review pathophysiology these CKD progression discuss non-drug drug interventions to attenuate in disorders. Non-pharmacological include reducing salt intake, normalizing body weight, avoiding superimposed injuries, smoking cessation regular physical activity. Approved inhibitors renin–angiotensin–aldosterone system sodium–glucose cotransporter-2. Numerous additional drugs improve care are currently being tested clinical trials. how when use different scenarios diseases.

Язык: Английский

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Animal models to study cognitive impairment of chronic kidney disease

AJP Renal Physiology, Год журнала: 2024, Номер 326(6), С. F894 - F916

Опубликована: Апрель 18, 2024

Mild cognitive impairment (MCI) is common in people with chronic kidney disease (CKD), and its prevalence increases progressive loss of function. MCI characterized by a decline performance greater than expected for an individual age education level but minimal instrumental activities daily living. Deterioration can affect one or several domains (attention, memory, executive functions, language, perceptual motor social cognition). Given the increasing disease, more CKD will also develop causing enormous burden these individuals, their relatives, society. However, underlying pathomechanisms are poorly understood, current therapies mostly aim at supporting patients lives. This illustrates urgent need to elucidate pathogenesis potential therapeutic targets test novel appropriate preclinical models. Here, we outline necessary criteria experimental modeling disorders CKD. We discuss use mice, rats, zebrafish as model systems present valuable techniques through which function be assessed this setting. Our objective enable researchers overcome hurdles accelerate research aimed improving therapy MCI.

Язык: Английский

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Recovery of Water Homeostasis in Adenine-Induced Kidney Disease Is Mediated by Increased AQP2 Membrane Targeting

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(6), С. 3447 - 3447

Опубликована: Март 19, 2024

Chronic kidney disease (CKD) represents a major public health burden with increasing prevalence. Current therapies focus on delaying CKD progression, underscoring the need for innovative treatments. This necessitates animal models that accurately reflect human pathologies, particularly studying potential reversibility and regenerative mechanisms, which are often hindered by progressive irreversible nature of most models. In this study, was induced in mice using 0.2% adenine-enriched diet 4 weeks, followed recovery period 1 or 2 weeks. The aim to characterize impact adenine feeding function injury as well water salt homeostasis throughout progression recovery. is characterized impaired renal function, tubular injury, inflammation, fibrosis. A significant decrease urine osmolality, coupled diminished aquaporin-2 (AQP2) expression membrane targeting, observed after treatment. Intriguingly, these parameters exhibited substantial increase two-week period. Despite functional improvements, only partial reversal damage, fibrosis were period, indicating inclusion molecular structural needed more complete monitoring status.

Язык: Английский

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Role of endoplasmic reticulum stress and autophagy in the transition from acute kidney injury to chronic kidney disease

Journal of Cellular Physiology, Год журнала: 2022, Номер 238(1), С. 82 - 93

Опубликована: Ноя. 21, 2022

Abstract Acute kidney injury (AKI) and chronic disease (CKD) are global health concerns with increasing rates in morbidity mortality. Transition from AKI‐to‐CKD is common requires awareness the management of AKI survivors. transition a main risk factor for development cardiovascular progression to end‐stage disease. The mechanisms driving being explored identify potential molecular cellular targets renoprotective drug interventions. Endoplasmic reticulum (ER) stress autophagy involved process transition. Excessive ER results persistent activation unfolded protein response, which an underneath cause cell death. Moreover, modulates vice‐versa. Autophagy degradation defensive mechanism protecting cells malfunction. However, underlying pathological this interplay context still unclear. In review, we discuss crosstalk between AKI, transition, CKD progression. addition, explore possible therapeutic that can regulate prevent improve long‐term prognosis

Язык: Английский

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Decoding pathology: the role of computational pathology in research and diagnostics

Pflügers Archiv - European Journal of Physiology, Год журнала: 2024, Номер unknown

Опубликована: Авг. 3, 2024

Abstract Traditional histopathology, characterized by manual quantifications and assessments, faces challenges such as low-throughput inter-observer variability that hinder the introduction of precision medicine in pathology diagnostics research. The advent digital allowed computational pathology, a discipline leverages methods, especially based on deep learning (DL) techniques, to analyze histopathology specimens. A growing body research shows impressive performances DL-based models for multitude tasks, mutation prediction, large-scale pathomics analyses, or prognosis prediction. New approaches integrate multimodal data sources increasingly rely multi-purpose foundation models. This review provides an introductory overview advancements discusses their implications future diagnostics.

Язык: Английский

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The Role of Platelet-Derived Growth Factor in Focal Segmental Glomerulosclerosis

Journal of the American Society of Nephrology, Год журнала: 2022, Номер 34(2), С. 241 - 257

Опубликована: Ноя. 9, 2022

FSGS is the final common pathway to nephron loss in most forms of severe or progressive glomerular injury. Although podocyte injury initiates FSGS, parietal epithelial cells (PECs) are main effectors. Because PDGF takes part fibrotic processes, we hypothesized that ligand PDGF-B and its receptor PDGFR- β participate origin progression FSGS.

Язык: Английский

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