medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 17, 2025
SARS-CoV-2
can
cause
a
variety
of
post-acute
sequelae
including
Long
COVID19
(LC),
complex,
multisystem
disease
characterized
by
broad
range
symptoms
fatigue,
cognitive
impairment,
and
post-exertional
malaise.
The
pathogenesis
LC
is
incompletely
understood.
In
this
study,
we
performed
comprehensive
cellular
transcriptional
immunometabolic
profiling
within
cohort
that
included
SARS-CoV-2-naïve
controls
(NC,
N=30)
individuals
with
prior
COVID-19
(∼4-months)
who
fully
recovered
(RC,
N=38)
or
went
on
to
experience
COVID
(N=58).
Compared
the
naïve
controls,
those
demonstrated
profound
metabolic
immune
alterations
at
proteomic,
cellular,
epigenetic
level.
Specifically,
there
was
an
enrichment
in
immature
monocytes
sustained
inflammasome
activation
oxidative
stress,
elevated
arachidonic
acid
levels,
decreased
tryptophan,
variation
frequency
phenotype
peripheral
T-cells.
Those
had
increased
CD8
T-cell
senescence
distinct
profile
CD4
T-cells
single
cell
RNA
sequencing.
Our
findings
support
persistent
dysfunction
follows
which
may
form
pathophysiologic
substrate
for
LC.
suggest
trials
therapeutics
help
restore
homeostasis
be
warranted
prevent,
reduce,
resolve
symptoms.
Nature Medicine,
Год журнала:
2024,
Номер
30(8), С. 2148 - 2164
Опубликована: Авг. 1, 2024
Long
COVID
represents
the
constellation
of
post-acute
and
long-term
health
effects
caused
by
SARS-CoV-2
infection;
it
is
a
complex,
multisystem
disorder
that
can
affect
nearly
every
organ
system
be
severely
disabling.
The
cumulative
global
incidence
long
around
400
million
individuals,
which
estimated
to
have
an
annual
economic
impact
approximately
$1
trillion-equivalent
about
1%
economy.
Several
mechanistic
pathways
are
implicated
in
COVID,
including
viral
persistence,
immune
dysregulation,
mitochondrial
dysfunction,
complement
endothelial
inflammation
microbiome
dysbiosis.
devastating
impacts
on
individual
lives
and,
due
its
complexity
prevalence,
also
has
major
ramifications
for
systems
economies,
even
threatening
progress
toward
achieving
Sustainable
Development
Goals.
Addressing
challenge
requires
ambitious
coordinated-but
so
far
absent-global
research
policy
response
strategy.
In
this
interdisciplinary
review,
we
provide
synthesis
state
scientific
evidence
assess
human
health,
systems,
economy
metrics,
forward-looking
roadmap.
BMC Infectious Diseases,
Год журнала:
2024,
Номер
24(1)
Опубликована: Янв. 15, 2024
Abstract
Background
Around
10%
of
people
infected
by
SARS-COV-2
report
symptoms
that
persist
longer
than
3
months.
Little
has
been
reported
about
sex
differences
in
and
clustering
over
time
non-hospitalised
patients
primary
care
settings.
Methods
This
is
a
descriptive
study
cohort
mainly
non-hospitalized
with
persistence
months
from
the
clinical
onset
co-creation
Long
Covid
Catalan
affected
group
using
an
online
survey.
Recruitment
was
March
2020
to
June
2021.
Exclusion
criteria
were
being
admitted
ICU,
<
18
years
age
not
living
Catalonia.
We
focused
on
117
gathered
groups
performed
cluster
analysis
first
21
days
infection,
at
22–60
days,
≥
Results
analysed
responses
905
participants
(80.3%
women).
Median
between
symptom
questionnaire
response
date
8.7
General
(as
fatigue)
most
prevalent
no
sex,
age,
or
wave
although
its
frequency
decreased
(from
91.8
78.3%).
Dermatological
(52.1%
women,
28.5%
men),
olfactory
(34.9%
20.9%
men)
neurocognitive
(70.1%
55.8%
showed
greatest
sex.
Cluster
five
clusters
predominance
Taste
&
smell
(24.9%)
Multisystemic
(26.5%)
baseline
_Multisystemic
(34.59%)
Heterogeneous
(24.0%)
≥3
The
more
men.
Menstrual
stable
time,
while
transitions
occurred
.
Conclusions
both
sexes
three-time
cut-off
points.
Major
observed
dermatological,
symptoms.
increase
might
suggest
adaptation
non-specific
evolution
condition
which
can
hinder
detection
medical
appointments.
A
carefully
collection
patients’
participation
research
may
generate
useful
knowledge
presentation
Frontiers in Public Health,
Год журнала:
2024,
Номер
12
Опубликована: Март 21, 2024
Introduction
Long
COVID
patients
experience
a
decrease
in
their
quality
of
life
due
to
the
symptomatology
produced
by
disease.
It
is
also
important
understand
how
long
affects
both
men
and
women.
The
objective
this
study
examine
impact
on
Spanish
adults
from
gender
perspective.
Methods
An
observational
cross-sectional
was
carried
out.
Participants
were
able
complete
an
online
questionnaire
using
platform.
A
sample
206
people
participated
study.
Results
80.6%
women
with
mean
age
46.51
(±8.28)
19.4%
48.03
(±9.50).
medium
score
PAC19-QoL
test
141.47
(±24.96)
segmented
gender,
141.65
(±23.95)
for
140.82
(±28.66)
men.
most
common
symptoms
muscle
joint
pain
(94.6%),
fatigue
(94.0%),
discomfort
(92.2%),
difficulty
concentrating
(91.0%),
memory
loss
(88.6%).
For
included
(97.5%)
occupying
first
position,
(92.0%),
(90.0%),
mood
disturbances
(87.5%).
chi-square
showed
statistical
significance
(
p
<
0.005)
socio-demographic
information,
scores,
intensities.
Conclusion
This
shows
that
there
are
differences
way
experienced.
Journal of Primary Care & Community Health,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 1, 2024
In
addition
to
the
morbidity
and
mortality
associated
with
acute
infection,
COVID-19
has
been
persistent
symptoms
(>30
days),
often
referred
as
Long
COVID
(LC).
LC
cluster
into
phenotypes,
resembling
conditions
such
fibromyalgia,
postural
orthostatic
tachycardiac
syndrome
(POTS),
myalgic
encephalomyelitis/chronic
fatigue
(ME/CFS).
clinics
have
established
best
address
needs
of
patients
continuity
care.
We
developed
a
cross-sectional
survey
assess
treatment
response
through
our
Clinic
(LCC).
Annals of Clinical and Translational Neurology,
Год журнала:
2024,
Номер
11(8), С. 2016 - 2029
Опубликована: Июнь 14, 2024
Abstract
Objective
Persisting
neurological
symptoms
after
COVID‐19
affect
up
to
10%
of
patients
and
can
manifest
in
fatigue
cognitive
complaints.
Based
on
recent
evidence,
we
evaluated
whether
cerebral
hemodynamic
changes
contribute
post‐COVID
syndrome
(PCS).
Methods
Using
resting‐state
functional
magnetic
resonance
imaging,
investigated
brain
perfusion
oxygen
level
estimates
47
(44.4
±
11.6
years;
F:M
=
38:9)
individually
matched
healthy
control
participants.
Group
differences
were
calculated
using
two‐sample
t
‐tests.
Multivariable
linear
regression
was
used
for
associations
each
regional
measure
with
cognition
sleepiness
measures.
Exploratory
hazard
ratios
metric
clinical
Results
Patients
presented
high
levels
(79%)
daytime
(45%).
We
found
widespread
decreased
levels,
most
evident
the
white
matter
(false
discovery
rate
adjusted‐
p
‐value
(
‐
FDR
)
0.038)
cortical
grey
0.015).
Brain
did
not
differ
between
However,
delayed
patient
caudate
nucleus
associated
better
executive
function
0.008).
Delayed
hippocampus
a
reduced
risk
(hazard
ratio
HR
0.07,
0.037
0.06,
0.034).
Decreased
putamen
poor
outcome
0.22,
0.019).
Meanwhile,
lower
thalamic
higher
6.29,
0.017).
Interpretation
Our
findings
blood
suggest
increased
metabolism
PCS,
which
potentially
holds
compensatory
function.
These
related
symptom
severity,
possibly
representing
metabolic
adaptations.