Persistent immune dysregulation and metabolic alterations following SARS-CoV-2 infection DOI Creative Commons
Silvia Lucena Lage,

Katherine Bricker-Holt,

Joseph M. Rocco

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

SARS-CoV-2 can cause a variety of post-acute sequelae including Long COVID19 (LC), complex, multisystem disease characterized by broad range symptoms fatigue, cognitive impairment, and post-exertional malaise. The pathogenesis LC is incompletely understood. In this study, we performed comprehensive cellular transcriptional immunometabolic profiling within cohort that included SARS-CoV-2-naïve controls (NC, N=30) individuals with prior COVID-19 (∼4-months) who fully recovered (RC, N=38) or went on to experience COVID (N=58). Compared the naïve controls, those demonstrated profound metabolic immune alterations at proteomic, cellular, epigenetic level. Specifically, there was an enrichment in immature monocytes sustained inflammasome activation oxidative stress, elevated arachidonic acid levels, decreased tryptophan, variation frequency phenotype peripheral T-cells. Those had increased CD8 T-cell senescence distinct profile CD4 T-cells single cell RNA sequencing. Our findings support persistent dysfunction follows which may form pathophysiologic substrate for LC. suggest trials therapeutics help restore homeostasis be warranted prevent, reduce, resolve symptoms.

Language: Английский

Long COVID science, research and policy DOI Creative Commons
Ziyad Al‐Aly, Hannah Davis, Lisa McCorkell

et al.

Nature Medicine, Journal Year: 2024, Volume and Issue: 30(8), P. 2148 - 2164

Published: Aug. 1, 2024

Long COVID represents the constellation of post-acute and long-term health effects caused by SARS-CoV-2 infection; it is a complex, multisystem disorder that can affect nearly every organ system be severely disabling. The cumulative global incidence long around 400 million individuals, which estimated to have an annual economic impact approximately $1 trillion-equivalent about 1% economy. Several mechanistic pathways are implicated in COVID, including viral persistence, immune dysregulation, mitochondrial dysfunction, complement endothelial inflammation microbiome dysbiosis. devastating impacts on individual lives and, due its complexity prevalence, also has major ramifications for systems economies, even threatening progress toward achieving Sustainable Development Goals. Addressing challenge requires ambitious coordinated-but so far absent-global research policy response strategy. In this interdisciplinary review, we provide synthesis state scientific evidence assess human health, systems, economy metrics, forward-looking roadmap.

Language: Английский

Citations

130
Mechanisms of long COVID and the path toward therapeutics DOI Creative Commons

Michael J. Peluso,

Steven G. Deeks

Cell, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

42
The gut microbiome associates with phenotypic manifestations of post-acute COVID-19 syndrome DOI
Qi Su, Raphaela Iris Lau, Qin Liu

et al.

Cell Host & Microbe, Journal Year: 2024, Volume and Issue: 32(5), P. 651 - 660.e4

Published: April 23, 2024

Language: Английский

Citations

20
Characterisation, symptom pattern and symptom clusters from a retrospective cohort of Long COVID patients in primary care in Catalonia DOI Creative Commons

Gemma Torrell,

Diana Puente, Constanza Jacques‐Aviñó

et al.

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 15, 2024

Abstract Background Around 10% of people infected by SARS-COV-2 report symptoms that persist longer than 3 months. Little has been reported about sex differences in and clustering over time non-hospitalised patients primary care settings. Methods This is a descriptive study cohort mainly non-hospitalized with persistence months from the clinical onset co-creation Long Covid Catalan affected group using an online survey. Recruitment was March 2020 to June 2021. Exclusion criteria were being admitted ICU, < 18 years age not living Catalonia. We focused on 117 gathered groups performed cluster analysis first 21 days infection, at 22–60 days, ≥ Results analysed responses 905 participants (80.3% women). Median between symptom questionnaire response date 8.7 General (as fatigue) most prevalent no sex, age, or wave although its frequency decreased (from 91.8 78.3%). Dermatological (52.1% women, 28.5% men), olfactory (34.9% 20.9% men) neurocognitive (70.1% 55.8% showed greatest sex. Cluster five clusters predominance Taste & smell (24.9%) Multisystemic (26.5%) baseline _Multisystemic (34.59%) Heterogeneous (24.0%) ≥3 The more men. Menstrual stable time, while transitions occurred . Conclusions both sexes three-time cut-off points. Major observed dermatological, symptoms. increase might suggest adaptation non-specific evolution condition which can hinder detection medical appointments. A carefully collection patients’ participation research may generate useful knowledge presentation

Language: Английский

Citations

13
How to understand the overlap of long COVID, chronic fatigue syndrome/myalgic encephalomyelitis, fibromyalgia and irritable bowel syndromes DOI
Don L. Goldenberg

Seminars in Arthritis and Rheumatism, Journal Year: 2024, Volume and Issue: 67, P. 152455 - 152455

Published: May 7, 2024

Language: Английский

Citations

10
The global clinical studies of long COVID DOI
Diego Ramonfaur, Nardeen Ayad,

Peter Hong Zhi Liu

et al.

International Journal of Infectious Diseases, Journal Year: 2024, Volume and Issue: 146, P. 107105 - 107105

Published: May 22, 2024

Language: Английский

Citations

10
Plasma exchange therapy for the post COVID-19 condition: a phase II, double-blind, placebo-controlled, randomized trial DOI Creative Commons
Sergio España-Cueto, Cora Loste,

Gemma Lladós

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 24, 2025

Language: Английский

Citations

2
Gender differences in symptomatology, socio-demographic information and quality of life in Spanish population with long COVID condition: a cross-sectional study DOI Creative Commons
Irene Marcilla-Toribio, Maria Leopolda Moratalla-Cebrián, Blanca Notario‐Pacheco

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: March 21, 2024

Introduction Long COVID patients experience a decrease in their quality of life due to the symptomatology produced by disease. It is also important understand how long affects both men and women. The objective this study examine impact on Spanish adults from gender perspective. Methods An observational cross-sectional was carried out. Participants were able complete an online questionnaire using platform. A sample 206 people participated study. Results 80.6% women with mean age 46.51 (±8.28) 19.4% 48.03 (±9.50). medium score PAC19-QoL test 141.47 (±24.96) segmented gender, 141.65 (±23.95) for 140.82 (±28.66) men. most common symptoms muscle joint pain (94.6%), fatigue (94.0%), discomfort (92.2%), difficulty concentrating (91.0%), memory loss (88.6%). For included (97.5%) occupying first position, (92.0%), (90.0%), mood disturbances (87.5%). chi-square showed statistical significance ( p &lt; 0.005) socio-demographic information, scores, intensities. Conclusion This shows that there are differences way experienced.

Language: Английский

Citations

7
Longitudinal Progression of Patients with Long COVID Treated in a Post-COVID Clinic: A Cross-Sectional Survey DOI Creative Commons
Ryan T. Hurt,

Siddhant Yadav,

Darrell R. Schroeder

et al.

Journal of Primary Care & Community Health, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 1, 2024

In addition to the morbidity and mortality associated with acute infection, COVID-19 has been persistent symptoms (>30 days), often referred as Long COVID (LC). LC cluster into phenotypes, resembling conditions such fibromyalgia, postural orthostatic tachycardiac syndrome (POTS), myalgic encephalomyelitis/chronic fatigue (ME/CFS). clinics have established best address needs of patients continuity care. We developed a cross-sectional survey assess treatment response through our Clinic (LCC).

Language: Английский

Citations

7
Altered brain perfusion and oxygen levels relate to sleepiness and attention in post‐COVID syndrome DOI Creative Commons
Claudia Chien, J. Heine, Ahmed A. Khalil

et al.

Annals of Clinical and Translational Neurology, Journal Year: 2024, Volume and Issue: 11(8), P. 2016 - 2029

Published: June 14, 2024

Abstract Objective Persisting neurological symptoms after COVID‐19 affect up to 10% of patients and can manifest in fatigue cognitive complaints. Based on recent evidence, we evaluated whether cerebral hemodynamic changes contribute post‐COVID syndrome (PCS). Methods Using resting‐state functional magnetic resonance imaging, investigated brain perfusion oxygen level estimates 47 (44.4 ± 11.6 years; F:M = 38:9) individually matched healthy control participants. Group differences were calculated using two‐sample t ‐tests. Multivariable linear regression was used for associations each regional measure with cognition sleepiness measures. Exploratory hazard ratios metric clinical Results Patients presented high levels (79%) daytime (45%). We found widespread decreased levels, most evident the white matter (false discovery rate adjusted‐ p ‐value ( ‐ FDR ) 0.038) cortical grey 0.015). Brain did not differ between However, delayed patient caudate nucleus associated better executive function 0.008). Delayed hippocampus a reduced risk (hazard ratio HR 0.07, 0.037 0.06, 0.034). Decreased putamen poor outcome 0.22, 0.019). Meanwhile, lower thalamic higher 6.29, 0.017). Interpretation Our findings blood suggest increased metabolism PCS, which potentially holds compensatory function. These related symptom severity, possibly representing metabolic adaptations.

Language: Английский

Citations

6