Journal of Agricultural and Food Chemistry,
Год журнала:
2022,
Номер
70(3), С. 711 - 735
Опубликована: Янв. 4, 2022
Owing
to
their
minimal
side
effects
and
effective
protection
from
oxidative
stress,
inflammation,
malignant
growth,
natural
polysaccharides
(NPs)
are
a
potential
adjuvant
therapy
for
several
diseases
caused
by
intestinal
barrier
injury
(IBI).
More
studies
accumulating
on
the
protective
of
NPs
with
respect
IBI,
but
underlying
mechanisms
remain
unclear.
Thus,
this
review
aims
represent
current
that
investigate
IBI
directly
maintaining
epithelial
integrity
(inhibiting
regulating
inflammatory
cytokine
expression,
increasing
tight
junction
protein
expression)
indirectly
immunity
microbiota.
Furthermore,
development
briefly
introduced,
structure–activity
relationships
discussed.
Potential
developments
challenges
associated
exhibiting
against
have
also
been
highlighted
guide
application
in
treatment
IBI.
Diabetes Metabolic Syndrome and Obesity,
Год журнала:
2019,
Номер
Volume 12, С. 2221 - 2236
Опубликована: Окт. 1, 2019
Abstract:
Westernized
populations
are
plagued
by
a
plethora
of
chronic
non-infectious
degenerative
diseases,
termed
as
"civilization
diseases",
like
obesity,
diabetes,
cardiovascular
cancer,
autoimmune
Alzheimer's
disease
and
many
more,
diseases
which
rare
or
virtually
absent
in
hunter-gatherers
other
non-westernized
populations.
There
is
growing
awareness
that
the
cause
this
amazing
discrepancy
lies
profound
changes
diet
lifestyle
during
recent
human
history.
This
paper
shows
transition
from
Paleolithic
nutrition
to
Western
diets,
along
with
lack
corresponding
genetic
adaptations,
significant
distortions
fine-tuned
metabolism
has
evolved
over
millions
years
evolution
adaptation
diets.
With
increasing
spread
worldwide,
overweight
civilization
also
rapidly
developing
countries.
It
suggested
diet-related
key
developmental
process
include
an
increased
production
reactive
oxygen
species
oxidative
stress,
development
hyperinsulinemia
insulin
resistance,
low-grade
inflammation
abnormal
activation
sympathetic
nervous
system
renin-angiotensin
system,
all
play
pivotal
roles
civilization.
In
addition,
epigenetic
fetal
programming
important
role.
The
pathomechanism
able
explain
well-known
but
not
completely
understood
close
relationship
between
obesity
wide
range
comorbidities,
type
2
diabetes
mellitus,
disease,
etc.,
same
etiopathology.
Changing
our
accordance
makeup,
including
physical
activity,
may
help
prevent
limit
these
diseases.
Keywords:
metabolic
syndrome,
hypersecretion,
paleolithic
diet,
pathogenesis
Free Radical Biology and Medicine,
Год журнала:
2022,
Номер
184, С. 114 - 134
Опубликована: Апрель 7, 2022
Type
2
diabetes
(T2DM)
is
a
persistent
metabolic
disorder
rising
rapidly
worldwide.
It
characterized
by
pancreatic
insulin
resistance
and
β-cell
dysfunction.
Hyperglycemia
induced
reactive
oxygen
species
(ROS)
production
oxidative
stress
are
correlated
with
the
pathogenesis
progression
of
this
disease.
To
counteract
harmful
effects
ROS,
endogenous
antioxidants
body
or
exogenous
neutralise
it
maintain
bodily
homeostasis.
Under
hyperglycemic
conditions,
imbalance
between
cellular
antioxidant
system
ROS
results
in
stress,
which
subsequently
development
diabetes.
These
produced
endoplasmic
reticulum,
phagocytic
cells
peroxisomes,
mitochondrial
electron
transport
chain
(ETC)
playing
pivotal
role.
The
exacerbated
can
directly
cause
structural
functional
modifications
proteins,
lipids
nucleic
acids.
also
modulates
several
intracellular
signaling
pathways
that
lead
to
impairment
function.
In
addition,
hyperglycemia-induced
contributes
micro-
macro-vascular
diabetic
complications.
Various
in-vivo
in-vitro
studies
have
demonstrated
anti-oxidative
natural
products
their
derived
bioactive
compounds.
However,
there
conflicting
clinical
evidence
on
beneficial
these
therapies
prevention.
This
review
article
focused
multifaceted
role
caused
overproduction
related
complications
possible
antioxidative
therapeutic
strategies
targeting
Journal of Experimental & Clinical Cancer Research,
Год журнала:
2018,
Номер
37(1)
Опубликована: Апрель 23, 2018
Radioresistance
is
a
major
factor
leading
to
the
failure
of
radiotherapy
and
poor
prognosis
in
tumor
patients.
Following
application
radiotherapy,
activity
various
metabolic
pathways
considerably
changes,
which
may
result
development
resistance
radiation.
Here,
we
discussed
relationships
between
radioresistance
mitochondrial
glucose
pathways,
aiming
elucidate
interplay
cell
metabolism
resistance.
In
this
review,
additionally
summarized
potential
therapeutic
targets
pathways.
The
aim
review
was
provide
theoretical
basis
relevant
references,
lead
improvement
sensitivity
prolong
survival
cancer
Antioxidants,
Год журнала:
2021,
Номер
10(2), С. 201 - 201
Опубликована: Янв. 30, 2021
Accumulating
evidence
shows
that
oxidative
stress
plays
an
essential
role
in
the
pathogenesis
and
progression
of
many
diseases.
The
imbalance
between
production
reactive
oxygen
species
(ROS)
antioxidant
systems
has
been
extensively
studied
pulmonary,
neurodegenerative
cardiovascular
disorders;
however,
its
contribution
is
still
debated
gastrointestinal
disorders.
Evidence
suggests
affects
motility
obesity,
post-infectious
disorders
by
favoring
smooth
muscle
phenotypic
switch
toward
a
synthetic
phenotype.
aim
this
review
to
gain
insight
into
played
pathologies
(GIT),
involvement
ROS
signaling
underlying
muscular
alterations
tract
(GIT).
In
addition,
potential
therapeutic
strategies
based
on
use
antioxidants
for
treatment
inflammatory
diseases
are
reviewed
discussed.
Although
substantial
progress
made
identifying
new
techniques
capable
assessing
presence
humans,
biochemical-molecular
mechanisms
GIT
mucosal
not
yet
well
defined.
Therefore,
further
studies
needed
clarify
through
which
stress-related
can
contribute
alteration
mucosa
order
devise
effective
preventive
curative
strategies.
Oxidative Medicine and Cellular Longevity,
Год журнала:
2019,
Номер
2019, С. 1 - 19
Опубликована: Май 5, 2019
Metabolic
syndrome
(MS)
represents
worldwide
public
health
issue
characterized
by
a
set
of
cardiovascular
risk
factors
including
obesity,
diabetes,
dyslipidemia,
hypertension,
and
impaired
glucose
tolerance.
The
link
between
the
MS
associated
diseases
is
represented
oxidative
stress
(OS)
intracellular
redox
imbalance,
both
caused
persistence
chronic
inflammatory
conditions
that
characterize
MS.
increase
in
oxidizing
species
formation
has
been
accepted
as
major
underlying
mechanism
for
mitochondrial
dysfunction,
accumulation
protein
lipid
oxidation
products,
impairment
antioxidant
systems.
These
modifications
are
recognized
relevant
OS
biomarkers
potentially
able
to
(i)
clarify
role
reactive
oxygen
nitrogen
etiology
MS,
(ii)
contribute
diagnosis/evaluation
disease's
severity,
(iii)
evaluate
utility
possible
therapeutic
strategies
based
on
natural
antioxidants.
therapies
indeed
could
be
counteract
systemic
well
mitochondrial-derived
OS,
enhance
endogenous
defenses,
alleviate
symptoms,
(iv)
prevent
complications
linked
MS-derived
diseases.
focus
this
review
summarize
current
knowledge
about
development
metabolic
alterations
characterizing
with
particular
regard
occurrence
OS-correlated
biomarkers,
use
Nutrients,
Год журнала:
2019,
Номер
11(6), С. 1356 - 1356
Опубликована: Июнь 16, 2019
Glycine
is
the
proteinogenic
amino-acid
of
lowest
molecular
weight,
harboring
a
hydrogen
atom
as
side-chain.
In
addition
to
being
building-block
for
proteins,
glycine
also
required
multiple
metabolic
pathways,
such
glutathione
synthesis
and
regulation
one-carbon
metabolism.
Although
generally
viewed
non-essential
amino-acid,
because
it
can
be
endogenously
synthesized
certain
extent,
has
been
suggested
conditionally
essential
amino
acid.
disorders
associated
with
obesity,
type
2
diabetes
(T2DM),
non-alcoholic
fatty
liver
disease
(NAFLDs),
lower
circulating
levels
have
consistently
observed,
clinical
studies
suggest
existence
beneficial
effects
induced
by
supplementation.
The
present
review
aims
at
synthesizing
recent
advances
in
metabolism,
pinpointing
its
main
identifying
causes
leading
deficiency—especially
obesity
disorders—and
evaluating
potential
benefits
increasing
availability
curb
progression
obesity-related
disturbances.
This
study
focuses
on
importance
diet,
gut
microbiota,
metabolism
determining
disorders.
Signal Transduction and Targeted Therapy,
Год журнала:
2021,
Номер
6(1)
Опубликована: Ноя. 10, 2021
Exosomes
play
a
role
as
mediators
of
cell-to-cell
communication,
thus
exhibiting
pleiotropic
activities
to
homeostasis
regulation.
Exosomal
non-coding
RNAs
(ncRNAs),
mainly
microRNAs
(miRNAs),
long
(lncRNAs),
and
circular
(circRNAs),
are
closely
related
variety
biological
functional
aspects
human
health.
When
the
exosomal
ncRNAs
undergo
tissue-specific
changes
due
diverse
internal
or
external
disorders,
they
can
cause
tissue
dysfunction,
aging,
diseases.
In
this
review,
we
comprehensively
discuss
underlying
regulatory
mechanisms
exosomes
in
addition,
explore
current
knowledge
on
roles
miRNAs,
lncRNAs,
circRNAs
health
diseases,
including
cancers,
metabolic
neurodegenerative
cardiovascular
autoimmune
infectious
determine
their
potential
implication
biomarker
identification
therapeutic
exploration.
