Environmental Pollution, Год журнала: 2025, Номер 370, С. 125866 - 125866
Опубликована: Фев. 19, 2025
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 1841 - 1841
Опубликована: Янв. 17, 2023
Classically, superoxide anion O
Язык: Английский
Процитировано
151
Antioxidants, Год журнала: 2022, Номер 11(11), С. 2213 - 2213
Опубликована: Ноя. 8, 2022
In recent years, there has been a growing interest in the application of antioxidants food and pharmaceuticals due to their association with beneficial health effects against numerous oxidative-related human diseases. The antioxidant potential can be measured by various assays specific mechanisms action, including hydrogen atom transfer, single electron targeted scavenging activities. Understanding chemistry mechanisms, advantages, limitations methods is critical for proper selection techniques valid assessment activity samples or conditions. There are analytical available determining biological samples, plant extracts. different categorized into three main groups, such as spectrometry, chromatography, electrochemistry techniques. Among these assays, spectrophotometric considered most common technique determination sensitivity, rapidness, low cost, reproducibility. This review covers mechanism actions color changes that occur each method. Furthermore, advantages described discussed this review.
Язык: Английский
Процитировано
124
Molecules, Год журнала: 2023, Номер 28(6), С. 2536 - 2536
Опубликована: Март 10, 2023
Polyphenols are an important component of plant-derived food with a wide spectrum beneficial effects on human health. For many years, they have aroused great interest, especially due to their antioxidant properties, which used in the prevention and treatment diseases. Unfortunately, as any chemical substance, depending conditions, dose, interactions environment, it is possible for polyphenols also exert harmful effects. This review presents comprehensive current state knowledge negative impact health, describing side polyphenol intake, form supplements. The begins brief overview physiological role potential use disease prevention, followed by exerted particular situations. individual chapters discuss consequences polyphenols’ ability block iron uptake, some subpopulations can be harmful, well inhibition digestive enzymes, intestinal microbiota, polyphenolic compounds drugs, hormonal balance. Finally, prooxidative activity mutagenic, carcinogenic, genotoxic presented. According authors, there need raise public awareness about supplementation, case vulnerable subpopulations.
Язык: Английский
Процитировано
96
Biomedicines, Год журнала: 2023, Номер 11(5), С. 1388 - 1388
Опубликована: Май 8, 2023
The human gastrointestinal tract is home to a complex microbial community that plays an important role in the general well-being of entire organism. gut microbiota generates variety metabolites and thereby regulates many biological processes, such as regulation immune system. In gut, bacteria are direct contact with host. major challenge here prevent unwanted inflammatory reactions on one hand other ensure system can be activated when pathogens invade. Here REDOX equilibrium utmost importance. This controlled by either directly or indirectly via bacterial-derived metabolites. A balanced microbiome sorts for stable balance, whereas dysbiosis destabilizes this equilibrium. An imbalanced status affects disrupting intracellular signaling promoting responses. we (i) focus most common reactive oxygen species (ROS) (ii) define transition from state oxidative stress. Further, (iii) describe ROS regulating Thereafter, (iv) examine influence homeostasis how shifts pro- anti-oxidative cellular conditions suppress promote responses inflammation.
Язык: Английский
Процитировано
72
Frontiers in Microbiology, Год журнала: 2024, Номер 15
Опубликована: Фев. 14, 2024
Recent studies have indicated that gut microbiota-mediated oxidative stress is significantly associated with intestinal diseases such as colorectal cancer, ulcerative colitis, and Crohn’s disease. The level of reactive oxygen species (ROS) has been reported to increase when the microbiota dysregulated, especially several bacterial metabolites are present. Although healthy plays a vital role in defending against excessive stress, disease influenced by ROS, this process controlled immunological responses, DNA damage, inflammation. In review, we discuss relationship between from an perspective. addition, also provide summary most recent therapeutic approaches for preventing or treating modifying microbiota.
Язык: Английский
Процитировано
32
Frontiers in Endocrinology, Год журнала: 2024, Номер 15
Опубликована: Июль 15, 2024
Inflammatory bowel disease (IBD) is a chronic immune-mediated condition that affects the digestive system and includes Crohn’s (CD) ulcerative colitis (UC). Although exact etiology of IBD remains uncertain, dysfunctional immunoregulation gut believed to be main culprit. Amongst immunoregulatory factors, reactive oxygen species (ROS) nitrogen (RNS), components oxidative stress event, are produced at abnormally high levels in IBD. Their destructive effects may contribute disease’s initiation propagation, as they damage lining activate inflammatory signaling pathways, further exacerbating inflammation. Oxidative markers, such malondialdehyde (MDA), 8-hydroxy-2’-deoxyguanosine (8-OHdG), serum-free thiols (R-SH), can measured blood stool patients with These markers elevated IBD, their correlate severity disease. Thus, used not only diagnosis but also monitoring response treatment. It targeted treatment through use antioxidants, including vitamin C, E, glutathione, N-acetylcysteine. In this review, we summarize role pathophysiology its diagnostic targets, potential application antioxidant therapies manage treat
Язык: Английский
Процитировано
26
Antioxidants, Год журнала: 2024, Номер 13(5), С. 504 - 504
Опубликована: Апрель 23, 2024
Despite the significant progress in fields of biology, physiology, molecular medicine, and pharmacology; designation properties nitrogen monoxide regulation life-supporting functions organism; numerous works devoted to this molecule, there are still many open questions field. It is widely accepted that nitric oxide (•NO) a unique molecule that, despite its extremely simple structure, has wide range body, including cardiovascular system, central nervous system (CNS), reproduction, endocrine respiration, digestion, etc. Here, we systematize •NO, contributing conditions physiological norms, as well various pathological processes, mechanisms cytoprotection cytodestruction. Current experimental clinical studies contradictory describing role •NO pathogenesis diseases CNS. We describe cytoprotective action associated with expression antiapoptotic chaperone proteins mitochondrial function. The most prominent cytodestruction—the initiation nitrosative oxidative stresses, production reactive oxygen species, participation apoptosis mitosis. formation endothelial dysfunction also considered. Moreover, focus on ways pharmacological modulation nitroxidergic allow for decrease cytodestructive increase ones.
Язык: Английский
Процитировано
20
Nature Reviews Urology, Год журнала: 2024, Номер 21(7), С. 433 - 449
Опубликована: Фев. 7, 2024
Язык: Английский
Процитировано
16
Journal of Molecular Liquids, Год журнала: 2024, Номер 402, С. 124786 - 124786
Опубликована: Апрель 21, 2024
Язык: Английский
Процитировано
16
Biomedicines, Год журнала: 2021, Номер 9(10), С. 1340 - 1340
Опубликована: Сен. 28, 2021
Lactobacilli and bifidobacteria are an important part of human gut microbiota. Among numerous benefits, their antioxidant properties attracting more attention. Multiple in vivo vitro studies have demonstrated that lactobacilli bifidobacteria, along with cellular components, possess excellent capacity, which provides a certain degree protection to the body against diseases associated oxidative stress. Recently, begun be considered as new source natural antioxidants. This review summarizes current state research on various bifidobacteria. Special emphasis is given mechanisms activity these bacteria microbiota, involve bacterial cell components metabolites. also dedicated genes involved strains indicators potential Identification biomarkers microbiota great importance both for creating diagnostic systems assessing stress choosing strategies aimed at restoring normal functioning and, through it, health. In this review, practical application probiotic proven prevent considered.
Язык: Английский
Процитировано
82