Biomolecules,
Год журнала:
2023,
Номер
13(2), С. 255 - 255
Опубликована: Янв. 30, 2023
A
high-fat
diet
is
one
of
the
causative
factors
obesity.
The
dietary
profile
fatty
acids
also
an
important
variable
in
developing
obesity,
as
saturated
are
more
obesogenic
than
monounsaturated
and
polyunsaturated
acids.
Overweight
obesity
inseparably
connected
with
excess
adipose
tissue
body,
characterized
by
hypertrophy
hyperplasia
fat
cells,
which
increases
risk
metabolic
syndrome.
Changes
observed
within
hypertrophic
adipocytes
result
elevated
oxidative
stress,
unfolded
protein
accumulation,
increased
endoplasmic
reticulum
(ER)
stress.
One
processes
involved
preservation
cellular
homeostasis
autophagy,
defined
intracellular
lysosome-dependent
degradation
system
that
serves
to
recycle
available
macromolecules
eliminate
damaged
organelles.
In
activation
autophagy
process
appears
be
regulated
different
types
This
review
describes
role
summarizes
current
understanding
effects
unsaturated
modulation
adipocytes.
Nutrients,
Год журнала:
2020,
Номер
12(8), С. 2393 - 2393
Опубликована: Авг. 10, 2020
The
prevention
and
treatment
of
obesity
is
primary
based
on
the
follow-up
a
healthy
lifestyle,
which
includes
diet
with
an
important
presence
bioactive
compounds
such
as
polyphenols.
For
many
years,
health
benefits
polyphenols
have
been
attributed
to
their
anti-oxidant
capacity
free
radical
scavengers.
More
recently
it
has
described
that
activate
other
cell-signaling
pathways
are
not
related
ROS
production
but
rather
involved
in
metabolic
regulation.
In
this
review,
we
summarized
current
knowledge
field
by
focusing
effects
flavonoids.
Flavonoids
widely
distributed
plant
kingdom
where
they
used
for
growing
defensing.
They
structurally
characterized
two
benzene
rings
heterocyclic
pyrone
ring
oxidation
saturation
status
flavonoids
grouped
seven
different
subclasses.
present
work
focused
describing
molecular
mechanisms
underlying
impact
obesity-related
diseases.
We
each
group
liver,
white
brown
adipose
tissue
central
nervous
system
signaling
them.
Diseases,
Год журнала:
2021,
Номер
9(3), С. 45 - 45
Опубликована: Июнь 23, 2021
Current
research
in
medicine
several
parts
of
the
world
has
attempted
to
establish
a
link
between
occurrence
neurodegenerative
pathologies,
microbiota
dysbiosis,
and
incidence
obesity.
The
body’s
response
different
physicochemical
factors
also
been
influenced
by
proper
assimilation
bioactive
compounds
contained
food
that
is
ingested.
Oxidative
stress
one
major
directly
affects
functioning
human
microbiota.
reaction
this
imbalance
crucial
progression
inflammatory
processes,
which
are
based
on
molecular
mechanisms.
Microbial
dysbiosis
can
result
possibly
permanent
alteration
physiological
response.
This
review
aims
highlight
recent
contributions
made
alleviating
degenerative
diseases,
especially
for
pathologies
rising
prevalence
We
discuss
significance
both
modulation
possible
alleviations
modulatory
function.
argue
pre-
probiotics
(including
phenolic
stimulating
favorable
strain
from
microbiota)
an
effective
alternative
support
pattern’s
over
time
attenuation
indirect
causes
determine
dysbiosis.
Molecular
aspects
presented
modulating
role
following
use
probiotics.
Cells,
Год журнала:
2022,
Номер
11(16), С. 2529 - 2529
Опубликована: Авг. 16, 2022
Neurological
diseases,
including
Parkinson’s
disease
(PD),
Alzheimer’s
(AD),
Huntington’s
(HD),
stroke,
cerebral
infarction,
ischemia-reperfusion
injury,
depression
and,
stress,
have
high
incidence
and
morbidity
often
lead
to
disability.
However,
there
is
no
particularly
effective
medication
against
them.
Therefore,
finding
drugs
with
a
suitable
efficacy,
low
toxicity
manageable
effects
improve
the
quality
of
life
patients
an
urgent
problem.
Ginsenoside
Rg1
(Rg1)
main
active
component
ginseng
has
variety
pharmacological
effects.
In
this
review,
we
focused
on
therapeutic
potential
for
improving
neurological
diseases.
We
introduce
mechanisms
in
apoptosis,
neuroinflammation,
microRNA
(miRNA)
family,
mitogen-activated
protein
kinase
(MAPK)
oxidative
nuclear
factor-κB
(NF-κB),
learning
memory
addition,
can
also
diseases
through
interaction
different
signal
pathways.
The
purpose
review
explore
more
in-depth
ideas
clinical
treatment
(including
PD,
AD,
HD,
ischemia–reperfusion
depression,
stress).
expected
become
new
method
Frontiers in Neuroscience,
Год журнала:
2023,
Номер
17
Опубликована: Фев. 15, 2023
Since
the
mid-20th
century,
Western
societies
have
considered
productivity
and
economic
outcomes
are
more
important
than
focusing
on
people's
health
wellbeing.
This
focus
has
created
lifestyles
with
high
stress
levels,
associated
overconsumption
of
unhealthy
foods
little
exercise,
which
negatively
affect
lives,
subsequently
lead
to
development
pathologies,
including
neurodegenerative
psychiatric
disorders.
Prioritizing
a
healthy
lifestyle
maintain
wellbeing
may
slow
onset
or
reduce
severity
pathologies.
It
is
win-win
for
everyone;
individuals.
A
balanced
increasingly
being
adopted
globally,
many
doctors
encouraging
meditation
prescribing
non-pharmaceutical
interventions
treat
depression.
In
disorders,
inflammatory
response
system
brain
(neuroinflammation)
activated.
Many
risks
factors
now
known
be
linked
neuroinflammation
such
as
stress,
pollution,
saturated
trans
fat
diet.
On
other
hand,
studies
habits
anti-inflammatory
products
lower
levels
reduced
risk
Sharing
protective
critical
so
that
individuals
can
make
informed
choices
promote
positive
aging
throughout
their
lifespan.
Most
strategies
manage
diseases
palliative
because
neurodegeneration
been
progressing
silently
decades
before
symptoms
appear.
Here,
we
preventing
by
adopting
an
integrated
"healthy"
approach.
review
summarizes
role
Antioxidants,
Год журнала:
2023,
Номер
12(6), С. 1172 - 1172
Опубликована: Май 29, 2023
Obesity
is
a
major
risk
factor
for
several
metabolic
diseases,
including
type
2
diabetes,
hyperlipidemia,
cardiovascular
and
brain
disorders.
Growing
evidence
suggests
the
importance
of
inter-organ
communication
progression
obesity
subsequent
onset
related
This
review
provides
broad
overview
pathophysiological
processes
that
from
adipose
tissue
dysfunction
leading
to
altered
multi-tissue
crosstalk
relevant
regulating
energy
homeostasis
etiology
obesity.
First,
comprehensive
description
role
was
reported.
Then,
attention
turned
toward
unhealthy
expansion
tissue,
low-grade
inflammatory
state,
inflexibility,
mitochondrial
as
root
causes
systemic
alterations.
In
addition,
short
spot
devoted
iron
deficiency
in
obese
conditions
hepcidin–ferroportin
relationship
management
this
issue.
Finally,
different
classes
bioactive
food
components
were
described
with
perspective
enhance
their
potential
preventive
therapeutic
use
against
obesity-related
diseases.
Aging and Disease,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Aging
in
the
healthy
brain
is
characterized
by
a
low-grade,
chronic,
and
sterile
inflammatory
process
known
as
neuroinflammaging.
This
condition,
mainly
consisting
an
up-regulation
of
response
at
level,
contributes
to
pathogenesis
age-related
neurodegenerative
disorders.
Development
this
proinflammatory
state
involves
interaction
between
genetic
environmental
factors,
able
induce
epigenetic
modifications.
Indeed,
exposure
compounds,
drugs,
infections,
can
contribute
modifications
DNA
methylome,
histone
fold
proteins,
nucleosome
positioning,
leading
modulation
neuroinflammatory
responses.
Furthermore,
some
modifiers,
which
combine
interact
during
life
course,
modeling
epigenome
dynamics
sustain,
or
dampen
phenotype.
The
aim
review
summarize
current
knowledge
about
neuroinflammaging
with
particular
focus
on
mechanisms
underlying
onset
progression
cascades
central
nervous
system;
furthermore,
we
describe
diagnostic
biomarkers
that
may
increase
accuracy
help
tailor
therapeutic
strategies
patients
diseases.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Апрель 12, 2024
Abstract
Neurodegenerative
diseases
(NDDs)
such
as
Alzheimer’s
disease,
Parkinson’s
and
amyotrophic
lateral
sclerosis
epitomize
a
class
of
insidious
relentless
neurological
conditions
that
are
difficult
to
cure.
Conventional
therapeutic
regimens
often
fail
due
the
late
onset
symptoms,
which
occurs
well
after
irreversible
neurodegeneration
has
begun.
The
integrity
blood-brain
barrier
(BBB)
further
impedes
efficacious
drug
delivery
central
nervous
system,
presenting
formidable
challenge
in
pharmacological
treatment
NDDs.
Recent
scientific
inquiries
have
shifted
focus
toward
peripheral
biological
systems,
investigating
their
influence
on
neuropathology
through
lens
extracellular
vesicles
(EVs).
These
vesicles,
distinguished
by
ability
breach
BBB,
emerging
dual
operatives
context
NDDs,
both
conveyors
pathogenic
entities
prospective
vectors
for
agents.
This
review
critically
summarizes
burgeoning
evidence
role
extracerebral
EVs,
particularly
those
originating
from
bone,
adipose
tissue,
gut
microbiota,
modulating
brain
pathophysiology.
It
underscores
duplicity
potential
EVs
modulators
disease
progression
suggests
novel
vehicles
targeted
delivery,
positing
transformative
impact
future
landscape
NDD
strategies.
Search
strategy
A
comprehensive
literature
search
was
conducted
using
PubMed,
Web
Science,
Scopus
January
2000
December
2023.
combined
following
terms
Boolean
operators:
“neurodegenerative
disease”
OR
“Alzheimer’s
“Parkinson’s
“Amyotrophic
sclerosis”
AND
“extracellular
vesicles”
“exosomes”
“outer
membrane
“drug
systems”
“blood-brain
barrier”.
MeSH
were
employed
when
searching
PubMed
refine
results.
Studies
included
if
they
published
English,
involved
human
subjects,
focused
origins
specifically
association
with
related
osteoporosis,
metabolic
syndrome,
dysbiosis.
Articles
excluded
did
not
address
NDDs
or
discuss
applications.
titles
abstracts
retrieved
articles
screened
dual-review
process
ensure
relevance
accuracy.
reference
lists
selected
also
examined
identify
additional
relevant
studies.
Current Alzheimer Research,
Год журнала:
2020,
Номер
16(14), С. 1254 - 1268
Опубликована: Янв. 3, 2020
Objective:
The
aim
of
this
study
is
to
assess
the
association
between
midlife
risk
factors
and
dementia.
Methods:
PubMed
Cochrane
library
were
systematically
searched
on
May
24,
2018,
retrieve
prospective
cohort
studies.
summary
Relative
Risk
(RR)
95%
Confidence
Interval
(CI)
calculated
by
random-effect
model
explore
Sensitivity
analysis
meta-regression
conducted
source
heterogeneity.
Publication
bias
was
examined
using
Begg's
Egger's
tests.
Results:
Thirty-four
studies
included,
among
which
24
eligible
for
metaanalysis.
A
total
159,594
non-demented
adults
enrolled
at
baseline
before
65
years
13,540
people
diagnosed
with
dementia
after
follow-up.
pooled
results
revealed
that
five
could
significantly
increase
41
78%,
including
obesity
(RR,
1.78;
CI:
1.31-2.41),
diabetes
mellitus
1.69;
1.38-2.07),
current
smoking
1.61;
95%,
1.32-1.95),
hypercholesterolemia
1.57;
1.19-2.07),
hypertension
(borderline
blood
pressure
RR,
1.41;
1.23-1.62
high
Systolic
Blood
Pressure
(SBP)
1.72;
1.25-2.37).
However,
sensitivity
analyses
found
SBP
not
reliable,
need
be
confirmed
more
high-quality
No
influences
due
publication
revealed.
In
systematic
review,
another
three
(hyperhomocysteinemia,
psychological
stress,
heavy
drinking)
associated
elevated
risk.
addition,
physical
exercise,
a
healthy
diet,
hormone
therapy
in
middle
age
reduction
Conclusions:
Middle-aged
obesity,
diabetes,
hypertension,
or
hypercholesterolemia,
smokers
are
higher
developing
later
life.
