European Association of Urology Guidelines on Sexual and Reproductive Health—2021 Update: Male Sexual Dysfunction

European Urology, Год журнала: 2021, Номер 80(3), С. 333 - 357

Опубликована: Июнь 26, 2021

Язык: Английский

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Erectile dysfunction and diabetes: A melting pot of circumstances and treatments

Diabetes/Metabolism Research and Reviews, Год журнала: 2021, Номер 38(2)

Опубликована: Сен. 13, 2021

Diabetes mellitus (DM), a chronic metabolic disease characterised by elevated levels of blood glucose, is among the most common diseases. The incidence and prevalence DM have been increasing over years. complications represent serious health problem. long-term include macroangiopathy, microangiopathy neuropathy as well sexual dysfunction (SD) in both men women. Erectile (ED) has considered important SD with DM. ED approximately 3.5-fold higher than those without Common risk factors for development its sedentary lifestyle, overweight/obesity increased caloric consumption. Although lifestyle changes may help improve function, specific treatments are often needed. This study aims to review definition DM, impact treatment on and, finally, current emerging therapies patients

Язык: Английский

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Relationship Between Age, Comorbidity, and the Prevalence of Erectile Dysfunction

European Urology Focus, Год журнала: 2022, Номер 9(1), С. 162 - 167

Опубликована: Авг. 26, 2022

Язык: Английский

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Relationship between weight-adjusted-waist index and erectile dysfunction in the United State: results from NHANES 2001-2004

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Апрель 25, 2023

The purpose of this study is to examine the association between a novel adiposity parameter, weight-adjusted-waist index (WWI), and erectile dysfunction (ED).According National Health Nutrition Examination Survey (NHANES) 2001-2004, total 3884 participants were categorized as ED non-ED individuals. WWI was calculated waist circumference (WC, cm) divided by square root weight (kg). Weighted univariable multivariable logistic regression models conducted assess correlation ED. Smooth curve fitting utilized linear association. receiver operating characteristic (ROC) DeLong et al.'s test applied compare area under (AUC) value predictive power among WWI, body mass (BMI), WC for ED.WWI positively related with full adjustment [odds ratio (OR)=1.75, 95% confidence interval (95% CI): 1.32-2.32, p=0.002]. After converting categorical variable quartiles (Q1-Q4), compared Q1 highest quartile linked an obviously increased likelihood (OR=2.78, CI: 1.39-5.59. p=0.010). Subgroup analysis revealed stability independent positive relationship It shown that had stronger prediction (AUC=0.745) than BMI (AUC=0.528) (AUC=0.609). Sensitivity performed verify significantly connection stricter (OR=2.00, 1.36-2.94, p=0.003).An elevated higher risks in United State adults, observed WC.

Язык: Английский

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The management of erectile dysfunction in men with diabetes mellitus unresponsive to phosphodiesterase type 5 inhibitors

Andrology, Год журнала: 2022, Номер 11(2), С. 257 - 269

Опубликована: Авг. 5, 2022

Erectile dysfunction is associated with diabetes mellitus an estimated prevalence of 52.5% in the diabetic population. The first-line therapy for erectile phosphodiesterase type 5 inhibitors, but data suggest that men may be less responsive than non-diabetic men. Thus, other treatments, including intracavernosal injections, intraurethral prostaglandin, vacuum erection devices and penile prosthetic surgery, should considered management refractory to inhibitors. Furthermore, combination inhibitors oral treatments such as arginine or l-carnitine have synergistic effects resulting better outcomes. In addition, there are novel therapies low-intensity shockwave stem-cell therapy, which also effective targeted treatment modalities. studies can improved by targeting concurrent comorbidities metabolic diseases depression, hypertension, hypogonadism, dyslipidaemia. We present evidence-based narrative review focusing on who not responded inhibitors.Both clinicians patients aware different options

Язык: Английский

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Association of BMI with erectile dysfunction: A cross-sectional study of men from an andrology clinic

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Март 30, 2023

Abnormal body mass index (BMI) is associated with an increased risk of erectile dysfunction (ED). However, the relationship between different BMI categories and levels ED severity remains unclear. In current study, 878 men from andrology clinic in Central China were recruited. Erectile function was assessed by International Index Function (IIEF) scores. Questionnaires included questions about demographic characteristics (age, height, weight, educational status), lifestyle habits (drinking, smoking, sleep time), medical history. Logistic regression used to examine association BMI. The incidence 53.1%. significantly higher group than those non-ED ( P = 0.01). Compared normal weight group, obese had a (OR 1.97, 95% CI 1.25-3.14, 0.004), even after adjustment for potential confounders 1.78, 1.10-2.90, 0.02). Moreover, positive correlation obesity moderate/severe confirmed logistic analysis (moderate/severe ED, OR 2.71, 1.44-5.04, 0.002), adjusting 2.51 1.24-5.09, Collectively, our findings indicate ED. Clinicians could pay more attention patients maintain healthy improve function.

Язык: Английский

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Investigating a novel surrogate indicator of adipose accumulation in relation to erectile dysfunction

Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)

Опубликована: Май 13, 2024

Abstract Introduction Although previous studies have linked obesity and erectile dysfunction, the novel surrogate indicators of adipose accumulation are more essential dependable factors to consider. Therefore, primary objective current investigation was examine clarify association between metabolic score for visceral fat (METS-VF) dysfunction. Methods Firstly, multivariate logistic regression analysis, smoothed curve fitting, threshold effect analysis were employed investigate METS-VF Mediation also performed evaluate mediating role homocysteine inflammation. After that, subgroup carried out stability correlation with dysfunction in various population settings. Furthermore, area under receiver operating characteristic (ROC) eXtreme Gradient Boosting (XGBoost) algorithm utilized assess capability identifying comparison other four obesity-related Results adjusting all confounding factors, strongly favourablely correlated With each additional unit rise METS-VF, prevalence increased by 141%. A J-shaped relationship discovered through fitting. Marital status, physical activity, smoking status can potentially modify this association. This finding ROC suggests that had a powerful capacity (AUC = 0.7351). Homocysteine inflammation mediated 4.24% 2.81%, respectively. Conclusion The findings suggest be considered indicator

Язык: Английский

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Erectile Dysfunction as an Obesity-Related Condition in Elderly Men with Coronary Artery Disease

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(7), С. 2087 - 2087

Опубликована: Апрель 3, 2024

Background: This cross-sectional study aimed to investigate the prevalence of erectile dysfunction (ED) in elderly men with overweight or obesity and coronary artery disease. Methods: Patients recruited cardiac rehabilitation centers post-myocardial infarction provided demographic anthropomorphic data. ED was assessed using abbreviated International Index Erectile Function 5 (IIEF-5) Questionnaire. Results: The included 661 a mean age 67.3 ± 5.57 years, BMI 27.9 3.6 m/kg2, waist circumference 98.9 10.23 cm. Over 90% experienced ED, similar proportions across categories. development ≥100 cm had 3.74 times higher odds (OR 3.74; 95% CI: 1.0-13.7; p = 0.04) than <100 Men moderate-to-severe severe were older compared those without these disorders (67.1 5.29 vs. 65.3 4.35; 0.23). Conclusions: disease surpasses 90%. An increased body weight raises risk proving be more reliable predictor this BMI. Physicians are encouraged screen patients cardiovascular for address enhance overall health.

Язык: Английский

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The global burden of erectile dysfunction and its associated risk factors in diabetic patients: an umbrella reviews

BMC Public Health, Год журнала: 2024, Номер 24(1)

Опубликована: Окт. 14, 2024

Abstract Background Erectile dysfunction is no longer a whisper in the shadows; it’s rising tide threatening sexual health of millions men different regions. In cases diabetes, condition worsens and has potent cocktail physical psychological distress, chipping away at men’s confidence, self-esteem, mental health. This worrying trend shows signs slowing down, with projections claiming staggering 322 million globally could be affected near future. urgent issue demands immediate attention action. Thus, this umbrella review intended to estimate current burden erectile associated risk factors among diabetic patients global context. Methods Following PRISMA guidelines, we searched for relevant studies PubMed, Embase, Scopus, Web Science, Cochrane Database Systematic Reviews, Google Scholar. These reported prevalence patients. The quality included was assessed using Assessment Multiple Reviews 2 tool. To pooled dysfunction, employed weighted inverse variance random-effects model. We further conducted subgroup analyses, heterogeneity publication bias, performed sensitivity analyses strengthen robustness our findings. Prediction intervals were also calculated range within which future observations will likely fall. all statistical significance declared P- value < 0.05. Results review, total 108 030 male dysfunction. 65.8% (95CI: 58.3 − 73.3%), while Africa it 62.9% 46.1–79.7). Age (> 40 years) (AOR = 1.95, 95CI: 1.03–3.24), DM duration 10years) 1.90,95CI: 1.16–2.65), peripheral vascular disease 2.74, 1.42–4.06) BMI 30 kg/m2) 1.07,95CI: 1.01–1.20) identified as patient. Conclusion high (ED) alarming, an estimated two-thirds experiencing condition. findings underscore significant ED faced by emphasize need issue. includes promoting early screening population ensuring access appropriate treatment support.

Язык: Английский

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Advanced hydrogels: New expectation for the repair of organic erectile dysfunction

Materials Today Bio, Год журнала: 2023, Номер 19, С. 100588 - 100588

Опубликована: Фев. 20, 2023

Organic erectile dysfunction (ED) is a type of sexual disorder in men that usually associated with illness, surgical injury, normal aging and has high incidence across the globe. And essence penile erection neurovascular event regulated by combination factors. Nerve vascular injury are main causes dysfunction. Currently, treatment options for ED include phosphodiesterase 5 inhibitors (PDE5Is), intracorporeal injections vacuum devices (VEDs), which ineffective. Therefore, it essential to find an emerging, non-invasive effective ED. The histopathological damage causing can be improved or even reversed hydrogels, contrast current therapies. Hydrogels have many advantages, they synthesized from various raw materials different properties, possess definite composition, good biocompatibility biodegradability. These advantages make hydrogels drug carrier. In this review, we began overview underlying mechanisms organic dysfunction, discussed dilemmas existing treatments ED, described unique hydrogel over other approaches. Then emphasizing progress research on

Язык: Английский

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