Roles for macrophage-polarizing interleukins in cancer immunity and immunotherapy

Cellular Oncology, Год журнала: 2022, Номер 45(3), С. 333 - 353

Опубликована: Май 19, 2022

Язык: Английский

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(Im)maturity in Tumor Ecosystem

Frontiers in Oncology, Год журнала: 2022, Номер 11

Опубликована: Янв. 25, 2022

Tumors have special features that make them distinct from their normal counterparts. Immature cells in a tumor mass and critical contributions to the tumorigenesis will open new windows toward cancer therapy. Incomplete cellular development brings versatile unique functionality ecosystem, such as what is seen for highly potential embryonic cells. There evidence maturation of certain types this ecosystem can recover sensitivity tumor. Therefore, understanding more about mechanisms contributed immaturity render therapeutic approaches Targeting be exploited supplementary current immunotherapeutic treatment schedules, immune checkpoint inhibitor (ICI) The key focus review discuss impact (im)maturity ecosystems on progression, focusing mainly cell compartment tumor, well stemness

Язык: Английский

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Epithelial-mesenchymal transition in cancer stemness and heterogeneity: updated

Medical Oncology, Год журнала: 2022, Номер 39(12)

Опубликована: Сен. 7, 2022

Язык: Английский

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HHLA2 immune-regulatory roles in cancer

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 162, С. 114639 - 114639

Опубликована: Апрель 1, 2023

Human endogenous retrovirus H long terminal repeat-associating protein 2 (HHLA2 or B7-H7) is a newly discovered B7 family member. HHLA2 aberrantly expressed in solid tumors and exerts co-stimulatory co-inhibitory activities dependent on interaction with counter receptors. represents effects upon transmembrane immunoglobulin domain containing (TMIGD2, also called CD28H), but its killer cell Ig-like receptor, three Ig domains cytoplasmic tail 3 (KIR3DL3) renders effects. TMIGD2 mainly resting naïve T cells, whereas expression of KIR3DL3 occurs activated cells. HHLA2/KIR3DL3 attenuates responses from both innate adaptive anti-tumor immunity, the activity within this axis regarded as biomarker weak prognosis cancer patients. promotes CD8+ exhaustion induces macrophage polarity toward pro-tumor M2 phenotype. diverse profile tumor stroma. Tumoral presumably higher compared programmed death-ligand 1 (PD-L1), co-expression PD-L1 indicative more severe outcomes. A suggested strategy patients HHLA2high to use monoclonal antibodies for specifically suppressing inhibitory receptor KIR3DL3, not ligand. can be target development agonistic bispecific hampering resistance death-1 (PD-1)/PD-L1 blockade therapy.

Язык: Английский

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The impact of hypoxia on extracellular vesicle secretome profile of cancer

Medical Oncology, Год журнала: 2023, Номер 40(5)

Опубликована: Март 24, 2023

Язык: Английский

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