Selenium nanoparticles stabilized by sweet corncob polysaccharide inhibit hypoglycemia in vitro and alleviate symptoms in type 2 diabetes mice DOI Creative Commons
Xin Wang, Jingyang Wang,

Weiye Xiu

и другие.

Journal of Functional Foods, Год журнала: 2023, Номер 112, С. 105920 - 105920

Опубликована: Дек. 5, 2023

In this investigation, we employed an oxidation–reduction method to synthesize selenium nanoparticles (SeNPs) and applied a coating of sweet corn polysaccharides (SCP) confer stability upon the SeNPs. We characterized SCP-coated SeNPs using dynamic light scattering, transmission electron microscopy, scanning X-ray photoelectron spectroscopy, diffractometry, Ultraviolet–visible spectrum, Fourier transform infrared spectroscopy. Our findings revealed that resulting possessed average particle size 127.82 nm exhibited superior inhibitory effects on α-amylase α-glucosidase when compared SCP in vitro experiments. The inhibition kinetics fluorescence quenching mechanism demonstrated action both enzymes was competitive nature, predominantly mediated by hydrophobic interactions hydrogen bonding. vivo experiments, promising hypoglycemic, hypolipidemic, antioxidant properties type 2 diabetes (T2DM) mice. Collectively, our study underscores remarkable potential ameliorating T2DM.

Язык: Английский

Synthesis, characterization and MAFLD prevention potential of Ganoderma lucidum spore polysaccharide-stabilized selenium nanoparticles DOI

Zhicheng Xiao,

Jiali Zhou,

Hanqi Chen

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 282, С. 136962 - 136962

Опубликована: Окт. 28, 2024

Язык: Английский

Процитировано

3
The efficacy of PDE5 inhibitors in diabetic patients DOI Creative Commons
Agnieszka Święcicka

Andrology, Год журнала: 2022, Номер 11(2), С. 245 - 256

Опубликована: Ноя. 11, 2022

Phosphodiesterase 5 inhibitors (PDE5i), since their introduction in the late 1990s, have proven efficacy treating several conditions, predominantly pulmonary hypertension and erectile dysfunction where they remain first-line therapeutic option. However, recent years, growing evidence from both animal human studies has emerged to suggest additional benefits of PDE5i cardiovascular metabolic disorders. This is specific interest diabetes population prevalent disease dysregulation significantly contribute increased morbidity mortality.To examine available data on non-standard, pleiotropic effects patients with mellitus.The review published background research, preclinical clinical trials.In studies, PDE5 inhibition appeared be associated reduced mortality overall improved outcomes those established disease. were also consistently found reduce albuminuria subjects diabetic nephropathy. Furthermore, a plausible effect this group medication sensory function neuropathic symptoms neuropathy as well wound healing. A decrease insulin resistance augmentation beta cell seen not been demonstrated models, appears oxidative stress some micro- macrovascular complications diabetes. trials are limited largely inconsistent, highlighting need for adequately powered, randomised-controlled cohorts order fully assess patients.

Язык: Английский

Процитировано

13
Intestinal Absorption of Nanoparticles to Reduce Oxidative Stress and Vasoconstriction for Treating Diabetic Nephropathy DOI

Chenxin Liu,

Mengxue Pang,

Qingyu Wang

и другие.

ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(3), С. 1517 - 1529

Опубликована: Фев. 20, 2024

The etiology of diabetic nephropathy (DN) is complex, and the incidence increasing year by year. patient's kidney showed oxidative stress damage, active oxygen species (ROS) content, vasoconstriction. Due to poor drug solubility low renal accumulation, current treatment regimens have not effectively alleviated glomerulopathy other damage caused DN. Therefore, it great significance explore new strategies delivery systems. Here, we constructed an oral nanodelivery system (Tel/CAN@CS-DA) that reduced Deoxycholic acid (DA)-modified nanoparticles entered into intestinal epithelial cells (Caco2 cells) via bile biomimetic pathway, then escaped from lysosomes eventually spat out cells, absorption nanoparticles. Chitosan (CS) could achieve targeting through specific binding with a giant protein receptor deliver drugs tubule (HK-2 cells). In vitro studies also proved telmisartan (Tel) canagliflozin (CAN) removed cellular reactive HK-2 cell apoptosis high glucose. in vivo model induced streptozotocin (STZ), results nanosystem only elevated AMPK expression, inhibited angiotensin II (Ang II) expression reduce level, dilated blood vessels but degree inflammation fibrosis. Overall, Tel/CAN@CS-DA multifunctional can treat DN toxicity, which provides idea for

Язык: Английский

Процитировано

2
Nanoselenium Alleviates Cadmium-Induced Cerebral Injury via Regulating Cerebral Metal Transporters and Metal-Regulatory Transcription Factor 1 DOI
Yaru Xu,

Milton Talukder,

Chenxi Li

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2023, Номер 71(25), С. 9896 - 9907

Опубликована: Июнь 12, 2023

Cadmium (Cd) is a hazardous environmental metal that poses global public health concern due to its high toxic potential. Nanoselenium (Nano-Se) nanoform of elemental Se widely used antagonize heavy toxicity owing safety margin with low doses. However, the role Nano-Se in relieving Cd-induced brain damage unclear. For this study, Cd-exposure-induced cerebral was established by using chicken model. Administration Cd significantly decreased Cd-mediated elevation ROS, MDA, and H2O2 levels as well markedly increased reduced activities antioxidant biomarkers (GPX, T-SOD, CAT, T-AOC). Accordingly, co-treatment accumulation recovered biometal imbalance, notably Zn. downregulated upregulation ZIP8, ZIP10, ZNT3, ZNT5, ZNT6 upregulated expressions ATOX1 XIAP. also mRNA MTF1 target genes MT1 MT2. Surprisingly, regulated total protein level reducing expression. Moreover, altered selenoproteins regulation after evidenced expression (GPx1-4 SelW) transport-related (SepP1 SepP2). The histopathological evaluation Nissl staining tissues supported microstructural alterations preserved normal histological architectures tissue. Overall, results research reveal may be beneficial mitigating injury brains chickens. This present study provides basis for preclinical usefulness potential therapeutic treatment neurodegeneration heavy-metal-induced neurotoxicity.

Язык: Английский

Процитировано

5
Selenium nanoparticles stabilized by sweet corncob polysaccharide inhibit hypoglycemia in vitro and alleviate symptoms in type 2 diabetes mice DOI Creative Commons
Xin Wang, Jingyang Wang,

Weiye Xiu

и другие.

Journal of Functional Foods, Год журнала: 2023, Номер 112, С. 105920 - 105920

Опубликована: Дек. 5, 2023

In this investigation, we employed an oxidation–reduction method to synthesize selenium nanoparticles (SeNPs) and applied a coating of sweet corn polysaccharides (SCP) confer stability upon the SeNPs. We characterized SCP-coated SeNPs using dynamic light scattering, transmission electron microscopy, scanning X-ray photoelectron spectroscopy, diffractometry, Ultraviolet–visible spectrum, Fourier transform infrared spectroscopy. Our findings revealed that resulting possessed average particle size 127.82 nm exhibited superior inhibitory effects on α-amylase α-glucosidase when compared SCP in vitro experiments. The inhibition kinetics fluorescence quenching mechanism demonstrated action both enzymes was competitive nature, predominantly mediated by hydrophobic interactions hydrogen bonding. vivo experiments, promising hypoglycemic, hypolipidemic, antioxidant properties type 2 diabetes (T2DM) mice. Collectively, our study underscores remarkable potential ameliorating T2DM.

Язык: Английский

Процитировано

5