Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Окт. 1, 2024
Язык: Английский
Drugs & Aging, Год журнала: 2024, Номер 41(5), С. 443 - 453
Опубликована: Апрель 2, 2024
Язык: Английский
Процитировано
5
Molecular Nutrition & Food Research, Год журнала: 2024, Номер 68(8)
Опубликована: Март 29, 2024
Abstract Cardiovascular diseases (CVDs) are a leading cause of global mortality and novel approaches for prevention management needed. The human gastrointestinal tract hosts diverse microbiota that is crucial in maintaining metabolic homeostasis. formulation effective probiotics, alone or combination, has been under discussion due to their impact on cardiovascular diseases. Probiotics have shown health positively. An imbalance the presence Firmicutes Bacteroidetes linked progression CVDs bile acid cholesterol metabolism. probiotics primarily help reduction plasma low‐density lipoprotein levels attenuation proinflammatory markers. These beneficial microorganisms contribute lowering produce essential short‐chain fatty acids. lipid‐regulating probiotic strains quite significant. However, only few tested potential efficacy, ambiguity exists regarding strain dosages, interactions with confounding factors, adverse effects. Hence, more comprehensive studies randomized trials needed understand mechanisms ensure health. This review assesses evidence highlights roles strain‐specific CVDs.
Язык: Английский
Процитировано
4
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Апрель 23, 2024
Abstract The angiotensin-converting enzyme 2 (ACE2) is a primary cell surface viral binding receptor for SARS-CoV-2, so finding new regulatory molecules to modulate ACE2 expression levels promising strategy against COVID-19. In the current study, we utilized islet organoids derived from human embryonic stem cells (hESCs), animal models and COVID-19 patients discover that fibroblast growth factor 7 (FGF7) enhances within islets, facilitating SARS-CoV-2 infection resulting in impaired insulin secretion. Using hESC-derived organoids, demonstrated FGF7 interacts with FGF (FGFR2) FGFR1 upregulate predominantly β cells. This upregulation increases both secretion susceptibility of infection. Inhibiting FGFR counteracts FGF7-induced upregulation, subsequently reducing replication islets. Furthermore, retrospective clinical data revealed diabetic severe symptoms exhibited elevated serum compared those mild symptoms. Finally, experiments indicated increased pancreatic levels, reduction concentrations situ. Taken together, our research offers potential by controlling FGF7, thereby protecting islets preventing progression diabetes context
Язык: Английский
Процитировано
4
Calcified Tissue International, Год журнала: 2024, Номер 115(2), С. 132 - 141
Опубликована: Июнь 3, 2024
Язык: Английский
Процитировано
4
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), Год журнала: 2025, Номер 21(2), С. 112 - 120
Опубликована: Апрель 1, 2025
Background. Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has led to widespread illness and global health challenges. While phase of infection been extensively studied, long-term effects, particularly in individuals who have recovered, remain unclear. Post-acute complications SARS-CoV-2 involves prolonged symptoms systemic disorders, including persistent inflammation, endothelial dysfunction, immune dysregulation, which often last for months. Among key factors contributing these conditions, there are pro-inflammatory cytokines, growth involved angiogenesis, hypoxia-inducible stress-related proteins, play a significant role tissue repair response modulation. The research aimed evaluate degree determine levels pro-angiogenic factors, сellular hypoxia marker HIF-1α, heat shock such as HSP60 HSP70, plasma healthy donors recovered from COVID-19, with particular focus on relationship between biomarkers anti-SARS-CoV-2 IgG titers. Materials methods. This ages 25 45 years, had COVID-19 at least 3 6 months prior beginning study. All patients were divided into groups based their inflammatory TNF-α, transcription factor NF-κB, angiogenic VEGF, PDGF FGF-2, hypoxic proteins measured enzyme-linked immunosorbent assay. Group differences analyzed using ANOVA Tukey’s test or Kruskal-Wallis Dunn’s test, presenting results median interquartile range, significance p ≤ 0.05. Results. study found parameters among donor varying There was an increase markers, TNF-α higher PDGF, FGF-2 showed distinct patterns, VEGF generally reduced, except group titers 95 ± 5 125 10 Index (S/C), where they significantly increased. notably 175 (S/C). HIF-1α also increased 75 (S/C) compared those without IgG. In contrast, HSP70 reduced all reference group, could indicate possible abnormalities mechanisms stress after COVID-19. Conclusions. Our suggest that activation, angiogenesis-related pathways crucial pathogenesis post-COVID-19 complications, underscoring need therapeutic strategies address chronic impaired recovery.
Язык: Английский
Процитировано
0
SN Comprehensive Clinical Medicine, Год журнала: 2025, Номер 7(1)
Опубликована: Апрель 24, 2025
Язык: Английский
Процитировано
0
Experimental Biology and Medicine, Год журнала: 2023, Номер 248(6), С. 532 - 540
Опубликована: Фев. 19, 2023
Heart failure (HF) is often associated with compromised physical capacity in patients. However, it unclear if established HF markers correlate the performance of patients congestive (CHF). We assessed left ventricular end-systolic dimension (LVESD) and ejection fraction (LVEF) and, parameters, including short battery (SPPB), gait speed (GS), handgrip strength (HGS) 80 CHF along 59 healthy controls. Furthermore, levels plasma galectin-3 heart-specific fatty acid binding protein (H-FABP) were measured relation to severity performance. Irrespective etiology, significantly greater LVESD lower LVEF observed versus As expected, H-FABP upregulated which accompanied by elevated zonulin inflammatory marker C-reactive (CRP). The SPPB scores, GS, HGS ischemic non-ischemic than level was inversely correlated scores (
Язык: Английский
Процитировано
8
Heliyon, Год журнала: 2023, Номер 9(9), С. e19485 - e19485
Опубликована: Авг. 25, 2023
BackgroundPostural dysfunction is a common problem in patients with Alzheimer's disease (AD) and may lead to functional dependency increasing morbidity mortality. However, the pathophysiology of postural AD remains poorly understood.ObjectivesElevated intestinal permeability an underlying contributor multiple diseases, including AD. We aimed investigate association elevated patients.Design Setting, Participants, Measurements: conducted cross-sectional, observational study on older adults, controls patients. investigated associations balance plasma zonulin, marker geriatric (n = 74) mild 71) moderate 66) used standardized physical performance battery measure supine, tandem, semi-tandem positions. also measured handgrip strength (HGS), gait speed as markers capacity.ResultsAD exhibited lower scores, HGS, higher zonulin than (all p < 0.05). Plasma levels demonstrated significant areas under curves diagnosing poor Moderate was associated capacity, (ALL P Poor scores scale were expressions inflammation, oxidative stress, muscle damage providing mechanistic link between increased patients.ConclusionThe results our show that measurement be diagnose The relevant non-ambulant and/or comatose dysfunction. Our findings highlight therapeutic potential repairing leak improve control reduce risk falls
Язык: Английский
Процитировано
8
Molecular Diagnosis & Therapy, Год журнала: 2024, Номер 28(5), С. 611 - 620
Опубликована: Июль 3, 2024
Язык: Английский
Процитировано
2
Archives of Gerontology and Geriatrics, Год журнала: 2024, Номер 127, С. 105587 - 105587
Опубликована: Июль 26, 2024
Язык: Английский
Процитировано
2