Archives of Gerontology and Geriatrics Plus,
Journal Year:
2024,
Volume and Issue:
1(3), P. 100034 - 100034
Published: May 7, 2024
The
potential
contributions
of
neuromuscular
junction
(NMJ)
degradation
to
muscle
loss
in
cancer
remain
poorly
understood.
We
investigated
the
biomarkers
NMJ
decline
patients
with
gynecological
carcinomas.
recruited
women
endometrial
(n=37,
56-73
years
old)
or
ovarian
(n=40,
55-72
carcinomas
along
age-matched
controls
(n=47,
55-71
controls,
divided
into
two
subgroups
based
on
presence
age-associated
loss,
termed
sarcopenia.
measured
plasma
c-terminal
agrin-fragment-32
(CAF22;
biomarker
loss),
neurofilament
light
chain
(NF-L;
neurodegeneration),
handgrip
strength
(HGS),
appendicular
skeletal
mass
index
(AMMI),
and
short
physical
performance
battery
(SPPB;
marker
capacity).
Patients
exhibits
low
HGS,
AMMI,
SPPB
higher
NF-L
levels
than
(all
p<0.05).
found
a
modest
elevation
CAF22
but
not
sarcopenia
was
associated
further
levels.
Higher
carcinoma
stages
were
both
groups
patients.
Collectively,
may
have
contribution
strategies
counter
target
intrinsic
changes
within
independent
NMJ.
Abstract
Cardiovascular
diseases
(CVDs)
are
a
leading
cause
of
global
mortality
and
novel
approaches
for
prevention
management
needed.
The
human
gastrointestinal
tract
hosts
diverse
microbiota
that
is
crucial
in
maintaining
metabolic
homeostasis.
formulation
effective
probiotics,
alone
or
combination,
has
been
under
discussion
due
to
their
impact
on
cardiovascular
diseases.
Probiotics
have
shown
health
positively.
An
imbalance
the
presence
Firmicutes
Bacteroidetes
linked
progression
CVDs
bile
acid
cholesterol
metabolism.
probiotics
primarily
help
reduction
plasma
low‐density
lipoprotein
levels
attenuation
proinflammatory
markers.
These
beneficial
microorganisms
contribute
lowering
produce
essential
short‐chain
fatty
acids.
lipid‐regulating
probiotic
strains
quite
significant.
However,
only
few
tested
potential
efficacy,
ambiguity
exists
regarding
strain
dosages,
interactions
with
confounding
factors,
adverse
effects.
Hence,
more
comprehensive
studies
randomized
trials
needed
understand
mechanisms
ensure
health.
This
review
assesses
evidence
highlights
roles
strain‐specific
CVDs.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: April 23, 2024
Abstract
The
angiotensin-converting
enzyme
2
(ACE2)
is
a
primary
cell
surface
viral
binding
receptor
for
SARS-CoV-2,
so
finding
new
regulatory
molecules
to
modulate
ACE2
expression
levels
promising
strategy
against
COVID-19.
In
the
current
study,
we
utilized
islet
organoids
derived
from
human
embryonic
stem
cells
(hESCs),
animal
models
and
COVID-19
patients
discover
that
fibroblast
growth
factor
7
(FGF7)
enhances
within
islets,
facilitating
SARS-CoV-2
infection
resulting
in
impaired
insulin
secretion.
Using
hESC-derived
organoids,
demonstrated
FGF7
interacts
with
FGF
(FGFR2)
FGFR1
upregulate
predominantly
β
cells.
This
upregulation
increases
both
secretion
susceptibility
of
infection.
Inhibiting
FGFR
counteracts
FGF7-induced
upregulation,
subsequently
reducing
replication
islets.
Furthermore,
retrospective
clinical
data
revealed
diabetic
severe
symptoms
exhibited
elevated
serum
compared
those
mild
symptoms.
Finally,
experiments
indicated
increased
pancreatic
levels,
reduction
concentrations
situ.
Taken
together,
our
research
offers
potential
by
controlling
FGF7,
thereby
protecting
islets
preventing
progression
diabetes
context
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine),
Journal Year:
2025,
Volume and Issue:
21(2), P. 112 - 120
Published: April 1, 2025
Background.
Coronavirus
disease
2019
(COVID-19),
caused
by
the
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
infection,
has
led
to
widespread
illness
and
global
health
challenges.
While
phase
of
infection
been
extensively
studied,
long-term
effects,
particularly
in
individuals
who
have
recovered,
remain
unclear.
Post-acute
complications
SARS-CoV-2
involves
prolonged
symptoms
systemic
disorders,
including
persistent
inflammation,
endothelial
dysfunction,
immune
dysregulation,
which
often
last
for
months.
Among
key
factors
contributing
these
conditions,
there
are
pro-inflammatory
cytokines,
growth
involved
angiogenesis,
hypoxia-inducible
stress-related
proteins,
play
a
significant
role
tissue
repair
response
modulation.
The
research
aimed
evaluate
degree
determine
levels
pro-angiogenic
factors,
сellular
hypoxia
marker
HIF-1α,
heat
shock
such
as
HSP60
HSP70,
plasma
healthy
donors
recovered
from
COVID-19,
with
particular
focus
on
relationship
between
biomarkers
anti-SARS-CoV-2
IgG
titers.
Materials
methods.
This
ages
25
45
years,
had
COVID-19
at
least
3
6
months
prior
beginning
study.
All
patients
were
divided
into
groups
based
their
inflammatory
TNF-α,
transcription
factor
NF-κB,
angiogenic
VEGF,
PDGF
FGF-2,
hypoxic
proteins
measured
enzyme-linked
immunosorbent
assay.
Group
differences
analyzed
using
ANOVA
Tukey’s
test
or
Kruskal-Wallis
Dunn’s
test,
presenting
results
median
interquartile
range,
significance
p
≤
0.05.
Results.
study
found
parameters
among
donor
varying
There
was
an
increase
markers,
TNF-α
higher
PDGF,
FGF-2
showed
distinct
patterns,
VEGF
generally
reduced,
except
group
titers
95
±
5
125
10
Index
(S/C),
where
they
significantly
increased.
notably
175
(S/C).
HIF-1α
also
increased
75
(S/C)
compared
those
without
IgG.
In
contrast,
HSP70
reduced
all
reference
group,
could
indicate
possible
abnormalities
mechanisms
stress
after
COVID-19.
Conclusions.
Our
suggest
that
activation,
angiogenesis-related
pathways
crucial
pathogenesis
post-COVID-19
complications,
underscoring
need
therapeutic
strategies
address
chronic
impaired
recovery.
Experimental Biology and Medicine,
Journal Year:
2023,
Volume and Issue:
248(6), P. 532 - 540
Published: Feb. 19, 2023
Heart
failure
(HF)
is
often
associated
with
compromised
physical
capacity
in
patients.
However,
it
unclear
if
established
HF
markers
correlate
the
performance
of
patients
congestive
(CHF).
We
assessed
left
ventricular
end-systolic
dimension
(LVESD)
and
ejection
fraction
(LVEF)
and,
parameters,
including
short
battery
(SPPB),
gait
speed
(GS),
handgrip
strength
(HGS)
80
CHF
along
59
healthy
controls.
Furthermore,
levels
plasma
galectin-3
heart-specific
fatty
acid
binding
protein
(H-FABP)
were
measured
relation
to
severity
performance.
Irrespective
etiology,
significantly
greater
LVESD
lower
LVEF
observed
versus
As
expected,
H-FABP
upregulated
which
accompanied
by
elevated
zonulin
inflammatory
marker
C-reactive
(CRP).
The
SPPB
scores,
GS,
HGS
ischemic
non-ischemic
than
level
was
inversely
correlated
scores
(
Heliyon,
Journal Year:
2023,
Volume and Issue:
9(9), P. e19485 - e19485
Published: Aug. 25, 2023
BackgroundPostural
dysfunction
is
a
common
problem
in
patients
with
Alzheimer's
disease
(AD)
and
may
lead
to
functional
dependency
increasing
morbidity
mortality.
However,
the
pathophysiology
of
postural
AD
remains
poorly
understood.ObjectivesElevated
intestinal
permeability
an
underlying
contributor
multiple
diseases,
including
AD.
We
aimed
investigate
association
elevated
patients.Design
Setting,
Participants,
Measurements:
conducted
cross-sectional,
observational
study
on
older
adults,
controls
patients.
investigated
associations
balance
plasma
zonulin,
marker
geriatric
(n
=
74)
mild
71)
moderate
66)
used
standardized
physical
performance
battery
measure
supine,
tandem,
semi-tandem
positions.
also
measured
handgrip
strength
(HGS),
gait
speed
as
markers
capacity.ResultsAD
exhibited
lower
scores,
HGS,
higher
zonulin
than
(all
p
<
0.05).
Plasma
levels
demonstrated
significant
areas
under
curves
diagnosing
poor
Moderate
was
associated
capacity,
(ALL
P
Poor
scores
scale
were
expressions
inflammation,
oxidative
stress,
muscle
damage
providing
mechanistic
link
between
increased
patients.ConclusionThe
results
our
show
that
measurement
be
diagnose
The
relevant
non-ambulant
and/or
comatose
dysfunction.
Our
findings
highlight
therapeutic
potential
repairing
leak
improve
control
reduce
risk
falls
