Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi,
Год журнала:
2024,
Номер
17(1), С. 164 - 173
Опубликована: Март 27, 2024
Breast
cancer
is
a
major
global
health
problem
that
imposes
significant
social
and
economic
burden
on
individuals
societies.
Chemotherapy,
common
treatment
approach,
often
leads
to
resistance
unwanted
side
effects,
especially
in
the
advanced
stages
of
disease.
This
has
led
search
for
more
effective
less
toxic
anticancer
agents.
Lichens,
which
are
associations
fungi
algae,
gaining
attention
their
potential
therapy.
Lichens
rich
sources
secondary
metabolites
with
diverse
biological
including
anti-tumor
properties.
In
this
study,
we
summarise
combined
effects
vulpinic
acid
(VA),
lichen
acid,
doxorubicin,
chemotherapeutic
drug,
breast
MCF-7
cells.
The
results
XTT
assay
subsequent
Compsyn
analysis
showed
VA
doxorubicin
(Dox),
alone
exhibited
potent
anti-proliferative
dose-
time-dependent
manner,
interestingly,
when
used
combination,
they
produced
an
antagonistic
effect
same
line.
These
provide
first
example
study
show
what
combination
Dox
will
have
other
cell
lines.
Journal of Applied Toxicology,
Год журнала:
2023,
Номер
43(11), С. 1676 - 1685
Опубликована: Июнь 17, 2023
Lung
cancer
is
the
leading
cause
of
cancer-related
deaths
all
over
world.
Therefore,
it
has
gained
importance
in
development
new
chemotherapeutic
strategies
to
identify
anticancer
agents
with
low
side
effects,
reliable,
high
potential,
and
specific
lung
cells.
Thioredoxin
reductase
1
(TrxR1)
an
important
therapeutic
target
for
treatment
because
its
overexpression
tumor
Here,
we
aimed
examine
effect
diffractaic
acid,
a
lichen
secondary
metabolite,
A549
cells
by
comparing
commercial
drug
carboplatin
also
investigate
whether
acid
occurs
via
TrxR1-targeting.
The
IC50
value
on
was
determined
as
46.37
μg/mL
at
48
h,
had
stronger
cytotoxicity
than
qPCR
results
revealed
that
promoted
intrinsic
apoptotic
pathway
through
upregulation
BAX/BCL2
ratio
P53
gene
cells,
which
consistent
flow
cytometry
results.
Furthermore,
migration
analysis
indicated
impressively
suppressed
While
enzymatic
activity
TrxR1
inhibited
no
changes
were
seen
quantitative
expression
levels
protein.
These
findings
provide
fundamental
data
targeting
activity,
suggesting
could
be
considered
agent
therapy.
Eurasian Journal of Medicine,
Год журнала:
2023,
Номер
54(Supp1), С. S195 - S208
Опубликована: Янв. 18, 2023
Lichens
are
a
unique
group
of
organisms,
which
can
produce
compounds
that
named
secondary
metabolites
and
rarely
or
not
produced
in
other
organisms.
possess
pharmacological
actions
related
to
their
metabolites.
Our
knowledge
lichens
rapidly
increases
as
new
technologies
devices,
facilitate
the
investigation
chemical
profile
biological
activities
lichens,
introduced
become
more
readily
available.
In
addition,
methods
perspectives,
well
suggestions
for
mechanisms,
accumulate
daily.
Furthermore,
lichen
substances
stand
relatively
untapped
source
natural
products.
Accordingly,
researchers
investigate
lichen-derived
material
frequently
than
it
was
past.
This
review
focused
on
published
last
11
years
(2012-2022).
Literature
data
obtained
from
WebOfScience
PubMed
databases
using
search
keywords
revealed
anti-genotoxicity,
anticancer,
anti-microbial
activity
studies
have
constantly
been
conducted.
More
recently,
immunomodulatory
inflammation-related
took
stage.
Enzyme
inhibition
were
popular
well.
selection
based
novelty
mechanistic
insight
papers
presented.
Technology in Cancer Research & Treatment,
Год журнала:
2023,
Номер
22
Опубликована: Янв. 1, 2023
Background
According
to
previous
literatures,
plasma
thioredoxin
reductase
(TrxR)
level
was
significantly
elevated
in
various
malignant
tumors
and
serve
as
a
potential
biomarker
for
diagnosis
prognostic
prediction.
However,
there
is
little
awareness
of
the
clinical
value
TrxR
gynecologic
malignancies.
In
present
study,
we
aim
evaluate
diagnostic
accuracy
cancer
explore
its
role
treatment
surveillance.
Methods
We
retrospectively
enrolled
134
patients
with
79
benign
disease.
The
difference
activity
tumor
markers
between
two
groups
compared
using
Mann-Whitney
U
test.
By
detecting
pretreatment
post-treatment
conventional
markers,
further
assessed
change
trend
them
Wilcoxon
signed-ranks
Results
Compared
control
[5.7
(5,
6.6)
U/mL],
statistically
significant
increase
observed
group
[8.4
(7.25,
9.825)
U/mL]
(
P
<
.0001),
regardless
age
stage.
On
basis
receiver
operating
characteristic
(ROC)
curves,
found
shows
highest
efficacy
distinguishing
malignancy
disease,
an
area
under
curve
(AUC)
0.823
(95%
confidence
interval
[CI]
=
0.767-0.878),
whole
cohort.
Besides,
receiving
previously
[8
(6.5,
9)
had
decreased
relative
treatment-native
[9.9
(8.6,
10.85)
U/mL].
Furthermore,
follow-up
data
showed
that
would
be
evidently
after
courses
antitumor
therapy
which
consistent
downward
markers.
Conclusion
Collectively,
all
these
results
demonstrated
effective
parameter
concurrently
acts
promising
response
assessment.
Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi,
Год журнала:
2024,
Номер
17(1), С. 164 - 173
Опубликована: Март 27, 2024
Breast
cancer
is
a
major
global
health
problem
that
imposes
significant
social
and
economic
burden
on
individuals
societies.
Chemotherapy,
common
treatment
approach,
often
leads
to
resistance
unwanted
side
effects,
especially
in
the
advanced
stages
of
disease.
This
has
led
search
for
more
effective
less
toxic
anticancer
agents.
Lichens,
which
are
associations
fungi
algae,
gaining
attention
their
potential
therapy.
Lichens
rich
sources
secondary
metabolites
with
diverse
biological
including
anti-tumor
properties.
In
this
study,
we
summarise
combined
effects
vulpinic
acid
(VA),
lichen
acid,
doxorubicin,
chemotherapeutic
drug,
breast
MCF-7
cells.
The
results
XTT
assay
subsequent
Compsyn
analysis
showed
VA
doxorubicin
(Dox),
alone
exhibited
potent
anti-proliferative
dose-
time-dependent
manner,
interestingly,
when
used
combination,
they
produced
an
antagonistic
effect
same
line.
These
provide
first
example
study
show
what
combination
Dox
will
have
other
cell
lines.
