International Journal of Life Science and Pharma Research,
Год журнала:
2023,
Номер
unknown
Опубликована: Ноя. 1, 2023
Rheumatoid
arthritis
(RA)
is
a
chronic
autoimmune
disorder
characterized
by
inflammation
and
damage
to
joints
andtissues.
While
previous
reviews
exist,
there
still
needs
be
more
in
understanding
risk
factors,
diagnostic
methods,
treatmentoptions.
This
review
aims
fill
these
gaps
providing
comprehensive
overview
of
recent
advancements
the
field.
To
addressthe
limitations
reviews,
this
article
incorporates
updated
information
on
including
influence
ofenvironmental
factors
industrialized
nations.
It
highlights
significance
early
RA
diagnosis
emphasizes
utility
ofdynamic
contrast-enhanced
magnetic
resonance
imaging
(DCE-MRI)
for
effective
disease
management.
Moreover,
reviewintroduces
innovative
nanotechnology-based
treatment
approaches
RA.
explores
potential
gold
nanoparticles,
carbonnanotubes,
polymer-based
nanomedicine,
nanoliposomes
targeting
specific
inflammatory
sites
improving
treatmenteffectiveness.
present
an
up-to-date
analysis
RA,
bridging
literature
byintroducing
novel
techniques
exploring
emerging
modalities.
By
synthesizing
current
knowledge
andoutlining
future
research
prospects,
advance
rheumatoid
arthritis.Additionally,
discusses
systemic
complications
associated
with
such
as
vasculitis
Feltysyndrome.
also
sheds
light
long-term
consequences
untreated
need
joint
replacementsurgery
(arthroplasty)
splenectomy.
aspects,
enhance
theholistic
guide
toward
improved
management
patient
outcomes.
Open Access Rheumatology Research and Reviews,
Год журнала:
2023,
Номер
Volume 15, С. 173 - 180
Опубликована: Сен. 1, 2023
Background:
Rheumatic
diseases
encompass
a
diverse
group
of
autoimmune
disorders
that
affect
the
joints
and
connective
tissues.
The
red
blood
cell
distribution
width
(RDW)
has
been
widely
investigated
as
an
inflammatory
marker.
This
scoping
review
aimed
to
explore
potential
utility
RDW
inexpensive
marker
for
disease
activity
in
patients
with
rheumatic
diseases.
By
summarizing
available
evidence,
we
determine
whether
can
serve
reliable
accessible
indicator
these
patients.
Methods:
A
comprehensive
search
was
systematically
performed
across
electronic
databases,
encompassing
PubMed,
Embase,
Web
Science.
Studies
have
explored
relationship
between
Data
extraction
focused
on
study
characteristics,
methodologies,
findings
related
Results:
After
removing
duplicates,
initial
yielded
25
relevant
studies.
These
studies
encompassed
variety
diseases,
rheumatoid
arthritis
being
most
frequently
studied
condition.
association
assessed
by
using
various
indices
clinical
parameters.
While
some
reported
significant
correlation
elevated
activity,
others
inconclusive
results.
Conclusion:
From
this
review,
concluded
is
evaluation
promising
readily
marker;
however,
its
assessing
conditions
warrants
more
rigorous
investigation
through
well-designed
prospective
Keywords:
width,
RDW,
marker,
Foods,
Год журнала:
2024,
Номер
13(6), С. 919 - 919
Опубликована: Март 18, 2024
Dietary
protein
supplementation
has
emerged
as
a
promising
strategy
in
combating
sarcopenia.
Furthermore,
searching
for
alternatives
of
animal
proteins
been
hot
topic.
The
present
study
aimed
to
investigate
the
effects
zein
peptides
on
C2C12
myoblasts
and
explore
their
potential
molecular
mechanisms.
proliferative,
cell
cycle,
anti-apoptotic
activities
were
evaluated.
Peptidomics
analysis
transcriptome
sequencing
employed
structure-activity
relationship
underlying
results
indicated
that
(0.05–0.2
mg/mL)
exerted
significant
proliferation-promoting
impact
cells,
via
increasing
viability
by
33.37
42.39%.
significantly
increased
S
phase
proportion
decreased
apoptosis
rate
from
34.08%
(model
group)
28.96%
cells.
In
addition,
exhibited
pronounced
effect
Zein
are
abundant
branch-chain
amino
acids,
especially
leucine.
Transcriptomics
revealed
can
promote
proliferation,
accelerate
improve
synthesis
muscle
cells
through
mTORC1
mTORC2
signaling
pathways.
The Yale Journal of Biology and Medicine,
Год журнала:
2024,
Номер
97(3), С. 399 - 413
Опубликована: Сен. 30, 2024
:
The
musculoskeletal
system,
due
to
inherent
structure
and
function,
lends
itself
contributing
toward
joint
pain,
whether
from
inflammatory
disorders
such
as
rheumatoid
arthritis,
degenerative
diseases
osteoarthritis,
or
trauma
causing
soft
tissue
injury.
Administration
of
peptides
for
treatment
pain
inflammation
is
an
emerging
line
therapy
that
seeks
offer
therapeutic
benefits
while
remaining
safe
relatively
non-invasive.
Asian Journal of Pharmaceutical Sciences,
Год журнала:
2024,
Номер
20(1), С. 101012 - 101012
Опубликована: Дек. 20, 2024
Arthritis
is
an
inflammatory
joint
disorder
that
progressively
impairs
function
and
diminishes
quality
of
life.
Conventional
therapies
often
prove
ineffective,
as
oral
administration
lacks
specificity,
resulting
in
off-target
side
effects
like
hepatotoxicity
GIT-related
issues.
Intravenous
causes
systemic
effects.
The
characteristic
joint-localized
symptoms
such
pain,
stiffness,
inflammation
make
the
localized
drug
delivery
suitable
for
managing
arthritis.
Topical/transdermal/intra-articular
routes
have
become
viable
options
treating
However,
challenges
with
those
include
skin
barrier
cartilage
impermeability.
Additionally,
conventional
intra-articular
also
leads
to
rapid
clearance
drugs
from
synovial
tissue.
To
circumvent
these
limitations,
researchers
developed
nanocarriers
enhance
permeability
through
cartilage,
influencing
action.
Gel-based
nanoengineered
therapy
employs
a
gel
matrix
incorporate
drug-encapsulated
nanocarriers.
This
approach
combines
benefits
gels
therapeutic
improve
patient
compliance.
review
emphasizes
deep
insights
into
using
diverse
gel-based
novel
nanocarriers,
exploring
their
various
applications
embedded
hyaluronic
acid
(biopolymer)-based
gels,
carbopol-based
others.
Furthermore,
this
discusses
influence
nanocarrier
pharmacokinetics
on
localization
manipulation
macrophages
mediated
by
ELVIS
(extravasation
leaky
vasculature
cell-mediated
sequestration)
effect
associated
arthritis
advantageous
delivery.
Simply
put,
refers
extravasation
vasculatures,
which
finally
results
accumulation
cavity.
International Journal of Life Science and Pharma Research,
Год журнала:
2023,
Номер
unknown
Опубликована: Ноя. 1, 2023
Rheumatoid
arthritis
(RA)
is
a
chronic
autoimmune
disorder
characterized
by
inflammation
and
damage
to
joints
andtissues.
While
previous
reviews
exist,
there
still
needs
be
more
in
understanding
risk
factors,
diagnostic
methods,
treatmentoptions.
This
review
aims
fill
these
gaps
providing
comprehensive
overview
of
recent
advancements
the
field.
To
addressthe
limitations
reviews,
this
article
incorporates
updated
information
on
including
influence
ofenvironmental
factors
industrialized
nations.
It
highlights
significance
early
RA
diagnosis
emphasizes
utility
ofdynamic
contrast-enhanced
magnetic
resonance
imaging
(DCE-MRI)
for
effective
disease
management.
Moreover,
reviewintroduces
innovative
nanotechnology-based
treatment
approaches
RA.
explores
potential
gold
nanoparticles,
carbonnanotubes,
polymer-based
nanomedicine,
nanoliposomes
targeting
specific
inflammatory
sites
improving
treatmenteffectiveness.
present
an
up-to-date
analysis
RA,
bridging
literature
byintroducing
novel
techniques
exploring
emerging
modalities.
By
synthesizing
current
knowledge
andoutlining
future
research
prospects,
advance
rheumatoid
arthritis.Additionally,
discusses
systemic
complications
associated
with
such
as
vasculitis
Feltysyndrome.
also
sheds
light
long-term
consequences
untreated
need
joint
replacementsurgery
(arthroplasty)
splenectomy.
aspects,
enhance
theholistic
guide
toward
improved
management
patient
outcomes.
