Cancer biotherapy: review and prospect
Clinical and Experimental Medicine,
Год журнала:
2024,
Номер
24(1)
Опубликована: Май 27, 2024
Abstract
Malignant
tumors
pose
a
grave
threat
to
the
quality
of
human
life.
The
prevalence
malignant
in
China
is
steadily
rising.
Presently,
clinical
interventions
encompass
surgery,
radiotherapy,
and
pharmaceutical
therapy
isolation
or
combination.
Nonetheless,
these
modalities
fail
completely
eradicate
tumor
cells,
frequently
leading
metastasis
recurrence.
Conversely,
biotherapy
has
emerged
as
an
encouraging
fourth
approach
preventing
managing
owing
its
safety,
efficacy,
minimal
adverse
effects.
Currently,
range
techniques
are
employed,
including
gene
therapy,
vaccines,
monoclonal
antibody
cancer
stem
cell
cytokine
adoptive
cellular
immunotherapy.
This
study
aims
comprehensively
review
latest
developments
biological
treatments
for
tumors.
Язык: Английский
Mechanism of deamination by mycobacterial deaminase selectively targeting mutagenic bases
Nucleic Acids Research,
Год журнала:
2025,
Номер
53(6)
Опубликована: Март 20, 2025
Abstract
Nucleobase
deaminases
are
important
players
in
maintaining
a
stringent
nucleobase
pool
and
enhancing
genetic
diversity
via
judicious
base
editing.
Here,
we
delineate
the
mechanism
of
Mycobacterium
smegmatis
deaminase,
Msd,
found
predominantly
species,
that
selectively
catalyzes
deamination
mutagenic
bases.
Molecular
dynamic
studies
reveal
nature
unique
structural
insertions
cycle
between
‘closed’
‘open’
states,
enabling
zinc-assisted
by
occluding
solvent.
Corroborating
X-ray
crystallographic
biochemical
assert
appropriate
length
two
gating
loops
proper
positioning
di-proline
motif
they
harbor
paramount
to
effective
closure.
Analysis
reveals
although
both
natural
deaminases,
guanine
cytosine
operate
similar
employ
topologically
differentially
placed
elements
achieve
form.
The
comparison
shows
lack
dual-proton
shuttle,
which
renders
them
ineffective
for
bases
but
allows
target
s-triazine
scaffolds,
thereby
imparting
innate
immunity
against
these
drugs.
study
highlights
how
cytidine
deaminase
fold
play
critical
role
harnessing
evolutionary
versatility,
responsible
fidelity
reaction.
Язык: Английский
Downregulation of transforming growth factor-β2 enhances the chemosensitivity to gemcitabine with diminished metastasis in pancreatic cancers
Biomedicine & Pharmacotherapy,
Год журнала:
2025,
Номер
188, С. 118151 - 118151
Опубликована: Май 15, 2025
Язык: Английский
Exploring the association between inflammatory biomarkers and gastric cancer development: A two-sample mendelian randomization analysis.
Medicine,
Год журнала:
2024,
Номер
103(5), С. e36458 - e36458
Опубликована: Фев. 2, 2024
This
study
aimed
to
elucidate
the
potential
causative
links
between
inflammatory
biomarkers
and
gastric
cancer
risk
via
a
two-sample
Mendelian
randomization
approach.
Leveraging
genome-wide
association
(GWAS)
data,
we
conducted
analysis.
Instrumental
variable
selection
for
markers
–
namely,
tissue
factor,
monocyte
chemotactic
protein-1,
E-selectin,
interleukin
6
receptor,
fatty
acid-binding
protein
4
was
informed
by
SNP
data
from
IEU
database.
Strongly
associated
SNPs
served
as
instrumental
variables.
We
applied
suite
of
statistical
methods,
including
Inverse
Variance
Weighted
(IVW),
Median
Estimator
(WME),
MR-Egger,
mode-based
estimates,
compute
odds
ratios
(ORs)
that
articulate
impact
these
on
susceptibility.
The
IVW
method
revealed
receptor
inversely
correlated
with
progression
(OR
=
0.86,
95%
CI
0.74–0.99,
P
.03),
whereas
found
elevate
1.21,
1.05–1.39,
.03).
variables
comprised
5,
4,
7,
2,
3
respectively.
Convergent
findings
WME,
analyses
corroborated
associations.
Sensitivity
checks,
heterogeneity,
horizontal
pleiotropy
assessments,
leave-one-out
diagnostics,
affirmed
robustness
reliability
our
instruments
across
diverse
malignancy
tissues
without
substantial
bias.
Our
research
suggests
potentially
mitigates,
while
may
contribute
pathogenesis
(GC).
Unraveling
intricate
biological
interplay
inflammation
oncogenesis
offers
valuable
insights
preemptive
strategies
therapeutic
interventions
in
management.
Язык: Английский