The immunological perspective of major depressive disorder: unveiling the interactions between central and peripheral immune mechanisms

Journal of Neuroinflammation, Год журнала: 2025, Номер 22(1)

Опубликована: Янв. 19, 2025

Major depressive disorder is a prevalent mental disorder, yet its pathogenesis remains poorly understood. Accumulating evidence implicates dysregulated immune mechanisms as key contributors to disorders. This review elucidates the complex interplay between peripheral and central components underlying pathology. Peripherally, systemic inflammation, gut dysregulation, dysfunction in organs including gut, liver, spleen adipose tissue influence brain function through neural molecular pathways. Within nervous system, aberrant microglial astrocytes activation, cytokine imbalances, compromised blood-brain barrier integrity propagate neuroinflammation, disrupting neurotransmission, impairing neuroplasticity, promoting neuronal injury. The crosstalk immunity creates vicious cycle exacerbating neuropathology. Unraveling these multifaceted immune-mediated provides insights into major disorder's pathogenic basis potential biomarkers targets. Modulating both responses represent promising multidimensional therapeutic strategy.

Язык: Английский

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Efficacy of erythropoietin as a neuroprotective agent in CKD-associated cognitive dysfunction: A literature systematic review

Pharmacological Research, Год журнала: 2024, Номер 203, С. 107146 - 107146

Опубликована: Март 16, 2024

Patients with chronic kidney disease (CKD) often experience mild cognitive impairment and other neurocognitive disorders. Studies have shown that erythropoietin (EPO) its receptor neuroprotective effects in cell animal models of nervous system Recombinant human EPO (rHuEPO), commonly used to treat anemia CKD patients, could be a agent. In this systematic review, we aimed assess the published studies investigating benefits rHuEPO treatment individuals reduced function. We comprehensively searched Pubmed, Cochrane Library, Scopus, Web Science databases from 1990 2023. After selection, 24 were analyzed, considering study design, sample size, participant characteristics, intervention, main findings. The collective results these patients indicated enhances brain function, improves performance on neuropsychological tests, positively affects electroencephalography measurements. These findings suggest promising agent for managing CKD-related impairment.

Язык: Английский

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Nobiletin: a potential erythropoietin receptor activator protects renal cells against hypoxia

APOPTOSIS, Год журнала: 2025, Номер unknown

Опубликована: Янв. 4, 2025

Язык: Английский

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Exploring the mechanism of Radix Bupleuri in the treatment of depression combined with SARS-CoV-2 infection through bioinformatics, network pharmacology, molecular docking, and molecular dynamic simulation

Metabolic Brain Disease, Год журнала: 2025, Номер 40(1)

Опубликована: Янв. 17, 2025

Язык: Английский

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PKR Inhibition Prevents Neuroinflammation and Rescues Depressive-Like Behaviors via BDNF/TrkB Signaling

Journal of Neuroimmune Pharmacology, Год журнала: 2025, Номер 20(1)

Опубликована: Фев. 4, 2025

Язык: Английский

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Investigating the Potential Therapeutic Targeting of the JAK-STAT Pathway in Cerebrovascular Diseases: Opportunities and Challenges

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Март 18, 2025

Язык: Английский

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Pentoxifylline Prevents Neuroinflammation and Modifies PTEN/TrkB Signaling in an LPS-Induced Depression Model

Journal of Neuroimmune Pharmacology, Год журнала: 2025, Номер 20(1)

Опубликована: Апрель 3, 2025

Язык: Английский

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Danggui-Shaoyao San Alleviates Cognitive Impairment via Enhancing HIF-1α/EPO Axis in Vascular Dementia Rats

Journal of Ethnopharmacology, Год журнала: 2024, Номер 331, С. 118306 - 118306

Опубликована: Май 7, 2024

Язык: Английский

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Anti-Photodamage Effect of Agaricus blazei Murill Polysaccharide on UVB-Damaged HaCaT Cells

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(9), С. 4676 - 4676

Опубликована: Апрель 25, 2024

UVB radiation is known to induce photodamage the skin, disrupt skin barrier, elicit cutaneous inflammation, and accelerate aging process. Agaricus blazei Murill (ABM) an edible medicinal nutritional fungus. One of its constituents, polysaccharide (ABP), has been reported exhibit antioxidant, anti-inflammatory, anti-tumor, immunomodulatory effects, which suggests potential effects that protect against photodamage. In this study, a UVB-induced HaCaT model was established investigate reparative ABP two constituents (A1 A2). Firstly, purified polysaccharides, A1 A2, were obtained by DEAE-52 cellulose column chromatography, their physical properties chemical structures studied. A2 exhibited network-like microstructure, with molecular weights 1.5 × 104 Da 6.5 Da, respectively. The on cell proliferation, mitochondrial membrane potential, inflammatory factors also explored. results show significantly promoted enhanced suppressed expression interleukin-1β (IL-1β), interleukin-8 (IL-8), interleukin-6 (IL-6), tumor necrosis factor α (TNF-α), increased relative content filaggrin (FLG) aquaporin-3 (AQP3). down-regulated JAK-STAT signaling pathway found play role in response These findings underscore ameliorate damage.

Язык: Английский

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Homotherapy-for-heteropathy of Bupleurum Chinense DC.-Scutellaria baicalensis Georgi in treating depression and colorectal cancer: A network pharmacology and animal model approach

Journal of Ethnopharmacology, Год журнала: 2024, Номер 328, С. 118038 - 118038

Опубликована: Март 12, 2024

Bupleurum chinense DC.-Scutellaria baicalensis Georgi (BS) is a classic drug pair that has good clinical effects on depression and many tumors. However, the concurrent targeting mechanism of how aforementioned valid in two distinct diseases, not been clarified yet. The components BS were detected by LC-MS, combined with network pharmacology to explore active ingredients common its multi-pathway regulation treating CRC, validate dual using CUMS mice model orthotopic transplantation tumor CRC. Twenty-nine screened, 84 gene targets obteined, top 5 key including STAT3, PIK3R1, PIK3CA, AKT1, IL-6 identified PPI network. GO KEGG analyses revealed PI3K/AKT JAK/STAT signaling pathways might play crucial role regulating significantly modulated CUMS-induced depressive-like behavior, attenuated neuronal damage, reduced serum EPI NE levels mice. improved pathological histological changes solid tumors liver tissues inhibited metastases CT26-bearing decreased proteins' expression IL-6, p-JAK2, p-STAT3, p-PI3K, p-AKT1 hippocampal tumors, regulated IL-2, IL-10 models can exert antidepressant anti-CRC inhibiting IL-6/JAK2/STAT3 pathway proteins release inflammatory cytokines.

Язык: Английский

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