Food and Chemical Toxicology,
Год журнала:
2025,
Номер
unknown, С. 115572 - 115572
Опубликована: Май 1, 2025
Exposure
to
4-vinylcyclohexene
diepoxide
(VCD)
has
been
associated
reproductive
toxicity,
However,
the
dynamic
ovarian
function
alterations
over
time
in
rats
and
underlying
mechanisms
remain
unclear.
This
study
investigated
effects
of
VCD
on
female
Sprague-Dawley
(SD)
25,
60
135
days
after
injection
discovered
related
mechanisms.
Our
results
showed
that
had
little
ovotoxicity
25th
day,
as
no
significant
changes
were
observed
except
for
reduction
preantral
follicles.
60th
day
135th
exhibited
irregular
estrous
cycles,
abnormal
serum
sex
hormone
levels,
morphological
damage,
decreased
primordial
follicles,
increased
atretic
We
further
found
might
exert
by
decreasing
antioxidant
enzyme
inhibiting
Kelch-like
ECH-associated
protein
1
(KEAP1)/nuclear
factor
erythroid
2-related
2
(NRF2)
PTEN-induced
putative
kinase
(PINK1)/E3
ubiquitin
ligase
(Parkin)
signaling
pathway.
Interestingly,
KEAP1/NRF2
PINK1/Parking
pathway
activated.
provided
a
wider
application
using
laboratory
rodents
model
failure
highlighted
VCD-induced
was
linked
regulation
PINK1/Parkin
pathways.
Journal of Ovarian Research,
Год журнала:
2024,
Номер
17(1)
Опубликована: Май 31, 2024
Abstract
In
women
who
are
getting
older,
the
quantity
and
quality
of
their
follicles
or
oocytes
decline.
This
is
characterized
by
decreased
ovarian
reserve
function
(DOR),
fewer
remaining
oocytes,
lower
oocytes.
As
more
choose
to
delay
childbirth,
decline
in
fertility
associated
with
age
has
become
a
significant
concern
for
modern
women.
The
oocyte
key
indicator
aging.
Many
studies
suggest
that
age-related
changes
energy
metabolism
may
impact
quality.
Changes
affect
adenosine
5'-triphosphate
(ATP)
production,
but
how
related
products
proteins
influence
remains
largely
unknown.
review
focuses
on
aging
its
potential
quality,
as
well
therapeutic
strategies
partially
metabolism.
research
aims
enhance
our
understanding
metabolism,
identification
biomarkers
treatment
methods.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(14), С. 7544 - 7544
Опубликована: Июль 9, 2024
Ferroptosis
is
a
type
of
nonapoptotic
cell
death
that
characteristically
caused
by
phospholipid
peroxidation
promoted
radical
reactions
involving
iron.
Researchers
have
identified
many
the
protein
factors
are
encoded
genes
promote
ferroptosis.
Glutathione
peroxidase
4
(GPX4)
key
enzyme
protects
phospholipids
from
and
suppresses
ferroptosis
in
glutathione-dependent
manner.
Thus,
dysregulation
involved
cysteine
and/or
glutathione
metabolism
closely
associated
with
From
perspective
dynamics,
actively
proliferating
cells
more
prone
to
than
quiescent
cells,
which
suggests
species
generated
during
oxygen-involved
responsible
for
lipid
peroxidation.
Herein,
we
discuss
initial
events
dominantly
occur
process
energy
metabolism,
association
deficiency.
Accordingly,
tricarboxylic
acid
cycle
coupled
respiratory
chain
mitochondria
main
subjects
here,
this
likely
source
both
electrons
free
Since
not
only
carbohydrates,
but
also
amino
acids,
especially
glutamate,
major
substrates
central
dealing
nitrogen
derived
groups
contributes
subject
discussion.
International Journal of Biological Sciences,
Год журнала:
2025,
Номер
21(4), С. 1837 - 1851
Опубликована: Фев. 10, 2025
Radiotherapy
is
the
primary
treatment
for
nasopharyngeal
carcinoma
(NPC);
nonetheless,
radioresistance
remains
leading
cause
of
localized
recurrence.
Our
study
demonstrates
a
significant
increase
in
N6-methyladenosine
(m6A)
methylase
METTL3
NPC
and
other
tumors.
Mechanistically,
acts
as
an
m6A
methylase,
enhancing
modification
solute
carrier
family
7
member
11
(SLC7A11)
transcript,
which
increases
its
stability
expression,
thereby
inhibiting
radiation-induced
ferroptosis
ultimately
inducing
NPC.
Furthermore,
silencing
SLC7A11
or
employing
inducer
Erastin
negated
promoting
effect
on
cell
radioresistance.
These
findings
suggest
that
could
be
novel
therapeutic
target
overcoming
radiotherapy
resistance
Antioxidants,
Год журнала:
2024,
Номер
13(5), С. 597 - 597
Опубликована: Май 13, 2024
Oxidative
stress
occurs
when
there
is
an
imbalance
between
the
production
of
reactive
oxygen
species
(ROS)
and
body’s
antioxidant
defenses.
It
poses
a
significant
threat
to
physiological
function
reproductive
cells.
Factors
such
as
xenobiotics
heat
can
worsen
this
stress,
leading
cellular
damage
apoptosis,
ultimately
decreasing
efficiency.
The
nuclear
factor
erythroid
2–related
2
(Nrf2)
signaling
pathway
plays
crucial
role
in
defending
against
oxidative
protecting
cells
via
enhancing
responses.
Dysregulation
Nrf2
has
been
associated
with
infertility
suboptimal
performance
mammals.
Recent
advancements
therapeutic
interventions
have
underscored
critical
mitigating
restoring
functional
integrity
In
narrative
review,
we
delineate
harmful
effects
xenobiotic-induced
on
explain
how
provides
protection
these
challenges.
studies
shown
that
activating
using
various
bioactive
compounds
ameliorate
distress
apoptosis
mammalian
By
comprehensively
analyzing
existing
literature,
propose
key
target
for
caused
by
exposure
xenobiotic
stress.
Additionally,
based
synthesis
findings,
discuss
potential
therapies
focused
improve
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Окт. 15, 2024
Spermidine
(SPD)
is
an
intermediate
compound
in
the
polyamine
metabolism
which
takes
critical
part
a
variety
of
cellular
processes.
In
particular,
it
has
been
reported
to
exert
anti-aging
effects,
suppress
age-related
diseases,
and
extend
lifespan
across
species.
However,
whether
favorable
influence
on
quality
postovulatory
aged
oocytes
remains
elusive.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(15), С. 8355 - 8355
Опубликована: Июль 30, 2024
During
the
development
of
animal
organs,
various
adverse
stimuli
or
toxic
environments
can
induce
oxidative
stress
and
delay
ovarian
development.
Paeoniflorin
(PF),
main
active
ingredient
traditional
Chinese
herb
