International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(20), С. 15330 - 15330
Опубликована: Окт. 18, 2023
Ovarian
aging
and
disease-related
decline
in
fertility
are
challenging
medical
economic
issues
with
an
increasing
prevalence.
Polyamines
a
class
of
polycationic
alkylamines
widely
distributed
mammals.
They
small
molecules
essential
for
cell
growth
development.
alleviate
ovarian
through
various
biological
processes,
including
reproductive
hormone
synthesis,
metabolism,
programmed
death,
etc.
However,
abnormal
increase
polyamine
levels
can
lead
to
damage
promote
the
development
disease.
Therefore,
polyamines
have
long
been
considered
potential
therapeutic
targets
disease,
but
their
regulatory
roles
ovary
deserve
further
investigation.
This
review
discusses
mechanisms
by
which
ameliorate
human
disease
different
such
as
autophagy
oxidative
stress,
develop
safe
effective
targeted
therapy
strategies
diseases.
Drug Design Development and Therapy,
Год журнала:
2025,
Номер
Volume 19, С. 4481 - 4500
Опубликована: Май 1, 2025
This
study
aimed
to
evaluate
the
therapeutic
potential
of
YS-10,
a
novel
flavonoid
derivative
icariside
II
(ICA
II),
and
explore
its
mechanism
action
in
diabetic
rat
model
erectile
dysfunction
(DMED).
Twenty-four
male
Sprague-Dawley
rats
were
divided
into
four
groups:
control,
DMED,
DMED
+
ICA
(2.5
mg/kg/day),
YS-10
mg/kg/day).
Treatments
lasted
for
4
weeks
followed
by
3-day
washout.
Erectile
function
was
assessed,
penile
tissues
analyzed
histology,
immunohistochemistry,
ELISA,
Western
blot.
In
vitro,
primary
corpus
cavernosum
endothelial
cells
(CCECs)
treated
with
advanced
glycation
end
products
(AGEs),
Fer-1
(ferroptosis
inhibitor),
or
ML385
(Nrf2
inhibitor)
oxidative
stress
ferroptosis.
vivo,
both
mg/kg/day)
significantly
improved
rats,
increased
smooth
muscle
content,
reduced
collagen
deposition,
enhanced
marker
(CD31)
expression
tissue
(p
<
0.01
vs
group).
The
maximum
ICP/MAP
ratio
markers
similarly
restored
treatment
groups,
no
significant
difference
between
>
0.05).
reversed
AGEs-induced
injury
ferroptosis
(CCECs),
upregulated
GPX4,
downregulated
ACSL4,
ROS
lipid
peroxidation,
comparable
effects
inhibitor
Fer-1.
also
promoted
Nrf2
nuclear
translocation
elevated
HO-1
expression.
Molecular
docking,
immunofluorescence,
blotconfirmed
interaction
Nrf2/HO-1/GPX4
signaling
pathway.
improves
reducing
inhibiting
via
activation
At
2.5
mg/kg/day,
effective,
well-tolerated,
showed
efficacy
II.
These
findings
support
as
promising
candidate
diabetes-related
therapy.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Май 29, 2025
The
depletion
of
ovarian
reserve
is
a
major
factor
contributing
to
the
decline
in
female
fertility.
It
characterized
by
simultaneous
reduction
quantity
and
quality
oocytes
follicular
pools.
cyclic
recruitment
primordial
follicles
preservation
oocyte
involve
complex
tightly
regulated
biological
processes.
Granulosa
cells,
which
surround
oocytes,
play
pivotal
role
development
determination
fate.
Programmed
cell
death
(PCD),
genetically
process
elimination,
key
regulation
dynamics.
Emerging
evidence
suggests
that
natural
products
derived
from
medicinal
plants,
dietary
components,
animals,
microorganisms
may
modulate
PCD
granulosa
cells
through
various
molecular
mechanisms
signaling
pathways.
These
have
demonstrated
preliminary
effects
delaying
aging
preserving
preclinical
models.
This
review
discusses
roles
underlying
forms
diminished
reserve,
while
summarizing
current
findings
on
influence
protect
function.
insights
contribute
future
novel,
targeted
strategies
aimed
at
reproductive
potential.
Food and Chemical Toxicology,
Год журнала:
2025,
Номер
unknown, С. 115572 - 115572
Опубликована: Май 1, 2025
Exposure
to
4-vinylcyclohexene
diepoxide
(VCD)
has
been
associated
reproductive
toxicity,
However,
the
dynamic
ovarian
function
alterations
over
time
in
rats
and
underlying
mechanisms
remain
unclear.
This
study
investigated
effects
of
VCD
on
female
Sprague-Dawley
(SD)
25,
60
135
days
after
injection
discovered
related
mechanisms.
Our
results
showed
that
had
little
ovotoxicity
25th
day,
as
no
significant
changes
were
observed
except
for
reduction
preantral
follicles.
60th
day
135th
exhibited
irregular
estrous
cycles,
abnormal
serum
sex
hormone
levels,
morphological
damage,
decreased
primordial
follicles,
increased
atretic
We
further
found
might
exert
by
decreasing
antioxidant
enzyme
inhibiting
Kelch-like
ECH-associated
protein
1
(KEAP1)/nuclear
factor
erythroid
2-related
2
(NRF2)
PTEN-induced
putative
kinase
(PINK1)/E3
ubiquitin
ligase
(Parkin)
signaling
pathway.
Interestingly,
KEAP1/NRF2
PINK1/Parking
pathway
activated.
provided
a
wider
application
using
laboratory
rodents
model
failure
highlighted
VCD-induced
was
linked
regulation
PINK1/Parkin
pathways.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(20), С. 15330 - 15330
Опубликована: Окт. 18, 2023
Ovarian
aging
and
disease-related
decline
in
fertility
are
challenging
medical
economic
issues
with
an
increasing
prevalence.
Polyamines
a
class
of
polycationic
alkylamines
widely
distributed
mammals.
They
small
molecules
essential
for
cell
growth
development.
alleviate
ovarian
through
various
biological
processes,
including
reproductive
hormone
synthesis,
metabolism,
programmed
death,
etc.
However,
abnormal
increase
polyamine
levels
can
lead
to
damage
promote
the
development
disease.
Therefore,
polyamines
have
long
been
considered
potential
therapeutic
targets
disease,
but
their
regulatory
roles
ovary
deserve
further
investigation.
This
review
discusses
mechanisms
by
which
ameliorate
human
disease
different
such
as
autophagy
oxidative
stress,
develop
safe
effective
targeted
therapy
strategies
diseases.
