Toxics,
Journal Year:
2024,
Volume and Issue:
12(8), P. 531 - 531
Published: July 23, 2024
Nanoplastics
(NPs)
cause
serious
contamination
of
drinking
water
and
potential
damage
to
human
health.
This
study
aimed
investigate
the
effects
NPs
with
different
particle
sizes
concentrations
on
reproductive
function
male
mice.
In
this
study,
free
exposure
was
used
expose
BALB/C
mice
PS-NPs
(20
nm,
200
1000
nm)
at
0.1
mg/L,
1
5
mg/L
for
4
months.
The
assessed
after
exposure,
fecal
blood
samples
were
collected
macrogenomics
metabolomics.
results
showed
that
resulted
in
reduced
testicular
organ
coefficients,
decreased
sperm
quality,
altered
tissue
structure,
disturbed
sex
hormone
levels,
abnormal
levels
inflammatory
factors
oxidative
stress.
Furthermore,
found
NP
affected
alteration
gut
communities
metabolic
pathways
related
reproduction,
such
as
Clostridium
glutathione
metabolism.
Importantly,
we
an
effect
size
function.
future,
more
attention
should
be
paid
smaller
NPs.
Cardiovascular Diagnosis and Therapy,
Journal Year:
2024,
Volume and Issue:
14(4), P. 576 - 588
Published: Aug. 1, 2024
Heart
failure
(HF)
remains
one
of
the
most
common
events
in
progression
hypertension.
Magnoflorine
(MNF)
has
been
shown
beneficial
effects
on
cardiovascular
system.
However,
action
MNF
angiotensin
(Ang)
II-induced
cardiac
remodeling
and
its
underlying
mechanisms
have
not
yet
characterised.
Here,
we
assessed
development
hypertension-related
HF.
Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Dec. 8, 2024
Abstract
Background
Granulosa
cell
(GC)
apoptosis,
ferroptosis,
and
other
programmed
death
processes
are
markers
of
follicular
aging.
Quercetin
has
been
shown
to
reduce
however,
its
effects
on
ferroptosis
in
poultry
remains
unexplored.
Our
preliminary
study
identified
aging
ovaries.
Therefore,
the
present
study,
540-day-old
Mountain
Plum-blossom
chickens
were
fed
with
quercetin
supplementation
at
varying
doses
(0.2,
0.4,
0.6
g/kg),
examined
molecular
GC
using
an
vitro
Erastin-induced
model.
Results
The
results
showed
that
significantly
increased
egg
production,
which
confirmed
potential
alleviate
chicken
ovarian
tissue.
experiment
revealed
Fer-1
(positive
control)
mitigated
GCs.
Further,
transcriptome
analysis
modulated
key
genes
such
as
acyl-CoA
synthetase
long-chain
family
member
4
(
ACSL4
),
solute
carrier
7
11
SLC7A11
transferrin
receptor
TFRC
involved
regulation.
further
also
reduced
apoptosis
inflammation
by
modulating
expression
proteins
related
inflammatory
factors
(NF-κB,
TNF-α,
IL-6,
IL-10).
Conclusion
Taken
together,
improves
production
performance
mitigates
hens,
inhibits
inflammation,
These
findings
protective
role
tissue
cellular
mechanisms
against
detrimental
production.
Graphical
Toxics,
Journal Year:
2024,
Volume and Issue:
12(8), P. 531 - 531
Published: July 23, 2024
Nanoplastics
(NPs)
cause
serious
contamination
of
drinking
water
and
potential
damage
to
human
health.
This
study
aimed
investigate
the
effects
NPs
with
different
particle
sizes
concentrations
on
reproductive
function
male
mice.
In
this
study,
free
exposure
was
used
expose
BALB/C
mice
PS-NPs
(20
nm,
200
1000
nm)
at
0.1
mg/L,
1
5
mg/L
for
4
months.
The
assessed
after
exposure,
fecal
blood
samples
were
collected
macrogenomics
metabolomics.
results
showed
that
resulted
in
reduced
testicular
organ
coefficients,
decreased
sperm
quality,
altered
tissue
structure,
disturbed
sex
hormone
levels,
abnormal
levels
inflammatory
factors
oxidative
stress.
Furthermore,
found
NP
affected
alteration
gut
communities
metabolic
pathways
related
reproduction,
such
as
Clostridium
glutathione
metabolism.
Importantly,
we
an
effect
size
function.
future,
more
attention
should
be
paid
smaller
NPs.
