Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Дек. 19, 2024
Radiotherapy
(RT)
is
a
primary
clinical
approach
for
cancer
treatment,
but
its
efficacy
often
hindered
by
various
challenges,
especially
radiation
resistance,
which
greatly
compromises
the
therapeutic
effectiveness
of
RT.
Mitochondria,
central
to
cellular
energy
metabolism
and
regulation
cell
death,
play
critical
role
in
mechanisms
radioresistance.
In
this
context,
cuproptosis,
novel
copper-induced
mitochondria-respiratory-dependent
death
pathway,
offers
promising
avenue
radiosensitization.
study,
an
innovative
theranostic
nanoplatform
was
designed
induce
cuproptosis
synergy
with
low-dose
therapy
(LDRT,
i.e.,
0.5–2
Gy)
treatment
situ
hepatocellular
carcinoma
(HCC).
This
aims
reverse
hypoxic
tumor
microenvironment,
promoting
shift
from
glycolysis
oxidative
phosphorylation
(OXPHOS),
thereby
enhancing
sensitivity
cuproptosis.
Concurrently,
Fenton-like
reaction
ensures
sustained
supply
copper
depletion
glutathione
(GSH),
inducing
disrupting
mitochondrial
function,
interrupting
supply.
strategy
effectively
overcomes
radioresistance
enhances
against
tumors.
conclusion,
study
elucidates
intricate
interactions
among
hypoxia
reversal,
metabolic
reprogramming,
radiosensitization,
particularly
context
treating
carcinoma,
providing
paradigm
radiotherapy.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
177, С. 117100 - 117100
Опубликована: Июль 15, 2024
Gastric
cancer
(GC)
is
the
fifth
most
prevalent
type
of
in
whole
world.
Cuproptosis
discovered
as
a
programmed
cell
death
pathway
and
connected
to
cells'
growth
death,
well
tumorigenesis.
The
relationship
between
cuproptosis
GC
still
elusive.
Two
aspects
this
study
will
elaborate
immunotherapy
biomarkers
GC.
Notably,
herein
review
intended
highlight
what
has
been
accomplished
regarding
for
diagnosis,
immunotherapy,
prognosis
aim
offer
potential
directions
strategies
future
research
inside
Environmental Science Nano,
Год журнала:
2024,
Номер
11(10), С. 4089 - 4101
Опубликована: Янв. 1, 2024
Our
work
suggested
that
cuproptosis
serves
as
a
key
toxic
mechanism
of
CuO
NPs,
damaging
mitochondria
to
induce
ferroptosis
by
disrupting
mitochondrial
membrane
lipid
synthesis.
Biological Trace Element Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 23, 2024
High
invasiveness
mesothelioma
is
a
malignant
tumor
of
the
peritoneum
or
pleura.
The
effect
cuproptosis
on
(MESO)
still
unknown,
though.
Cancer
Genome
Atlas
(TCGA)
and
Gene
Expression
Omnibus
(GEO)
datasets
were
used
to
identify
differential
genes
linked
in
mesothelioma.
Multigene
features
then
created
assess
course
disease.
Use
single-cell
data
vitro
validation
uncover
crucial
gene
regulation
mechanisms.
In
MESO,
we
found
nine
differentially
expressed
cuproptosis.
Using
univariate
Cox
LASSO
regression
techniques,
3-gene
feature
(P
<
0.05)
was
created,
showing
good
predictive
potential
for
survival
time.
According
risk
score,
patients
low-risk
subset
had
considerably
greater
rate
than
those
high-risk
=
0).
similar
pattern
prediction
performance
are
also
seen
queue.
findings
drug
sensitivity
research
indicate
that
patients,
vinblastine,
paclitaxel,
gefitinib,
erlotinib
sensitive
medications
0.05).
Classical
monocytes
identified
as
core
cells
connected
by
CellChat
results.
SLC31A1
implicated
positive
M2
macrophage
polarization,
according
cell
subtype
analysis
confirmation.
Genes
have
major
influence
immunity
can
predict
how
MESO
will
progress.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 9, 2025
Copper
is
an
essential
micronutrient
involved
in
various
physiological
processes
cell
types.
Consequently,
dysregulation
of
copper
homeostasis-either
excessive
or
deficient-can
lead
to
pathological
changes,
such
as
heart
failure
(HF).
Recently,
a
new
type
copper-dependent
death
known
cuproptosis
has
drawn
increasing
attention
the
impact
dyshomeostasis
on
HF.
Notably,
was
associated
with
occurrence
Hence,
this
review
aimed
investigate
biological
uptake,
transport,
excretion,
and
storage
at
both
cellular
systemic
levels
terms
HF,
along
underlying
mechanisms
action.
Additionally,
role
its
related
mitochondrial
dysfunction
HF
pathogenesis
analyzed.
Finally,
we
reviewed
therapeutic
potential
current
drugs
that
target
metabolism
for
treating
Overall,
conclusions
revealed
copper-based
therapies
development
strategies
treatment
Animals,
Год журнала:
2025,
Номер
15(2), С. 184 - 184
Опубликована: Янв. 11, 2025
This
experiment
investigated
the
effects
of
dietary
supplementation
with
nano-composites
copper
and
carbon
(NCCC)
on
antioxidants,
immune
functions,
cecum
microbiota
weaned
Ira
white
rabbits.
A
total
240
35-day-old
rabbits
were
randomly
allocated
to
five
treatments
(n
=
6
per
treatment,
each
replicate
consisted
eight
rabbits)
that
included
control
group
(CON)
a
basal
diet,
SAL
60
mg/kg
salinomycin
(SAL)
in
addition
NCCC
I,
II,
III
groups,
which
supplemented
50,
100,
200
NCCC,
respectively,
diet.
The
test
lasted
for
28
d.
results
showed
increased
liver
Cu/Zn-SOD
content
up-regulated
gene
expression
(p
<
0.05),
while
also
reducing
MDA
enhancing
antioxidant
capacity
Moreover,
diet
reduced
IL-6
down-regulated
relative
IL-1β
genes
jejunum
0.05).
In
addition,
metagenomic
analysis
16
S
rRNA
significant
differences
cecal
microbial
structure
compared
CON,
II
groups
Firmicutes
Bacteroidetes
dominant
phyla
microorganisms
groups.
genera
unidentified
Eubacteriaceae,
unclassified
Lachnospiraceae,
Christensenellaceae,
Ruminococcus.
Furthermore,
abundance
Ruminococcus
I
was
lower
than
CON
summary,
our
could
enhance
liver,
alleviate
intestinal
inflammation,
regulate
flora,
improving
health
Cells,
Год журнала:
2025,
Номер
14(3), С. 199 - 199
Опубликована: Янв. 29, 2025
Cuproptosis
is
a
novel
cell
death
dependent
on
mitochondrial
respiration
and
regulated
by
copper.
While
the
study
of
it
mainly
focused
tumor
therapy,
in
present
study,
two
key
cuproptosis-related
genes,
ferredoxin
(FDX1)
dihydrolipoamide
S-acetyltransferase
(DLAT)
homologs
(designated
as
CgFDX1
CgDLAT),
were
identified
from
Crassostrea
gigas.
has
Fer2
domain
with
2Fe-2S
cluster
forming
unique
ferredoxin.
CgDLAT
composed
biotin_lipoyl
domain,
an
E3-binding
2-oxoacid_dh
domain.
mRNA
expressed
all
examined
tissues.
After
elesclomol
treatment,
both
protein
expressions
them
reduced
hemocytes.
The
mortality
rate
hemocytes
increased
significantly,
accompanied
noticeable
adhesive
abnormalities
heightened
secretion
after
treatment.
Additionally,
accumulation
or
depletion
actin
was
observed
integrity
double
membrane
structure
mitochondria
compromised,
organization
cristae
disrupted.
contents
copper,
malondialdehyde
(MDA),
pyruvic
acid
mitoSOX
well
ratio
cells
low
potential
significantly
upon
treatment
content
citric
decreased
significantly.
These
findings
suggest
presence
cuproptosis
oysters
its
activation
mechanism
relatively
conserved
evolution.
