Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Ноя. 19, 2024
Heart
failure
(HF)
and
cancer
share
common
risk
factors
pathophysiological
mechanisms,
including
fibrosis.
Identifying
biomarkers
therapeutic
targets
for
both
conditions
is
crucial.
RNA
sequencing
data
from
HF
patients
were
analyzed
to
identify
12
genes
associated
with
myocardial
Validation
was
performed
using
public
datasets,
functional
enrichment
analyses
conducted.
Gene
expression
patterns
prognostic
value
in
various
cancers
assessed.
Fibromodulin
(FMOD),
Periostin
(POSTN),
Latent
Transforming
Growth
Factor
Beta
Binding
Protein
2
(LTBP2),
Collagen
Type
I
Alpha
1
Chain
(COL1A1),
VIII
(COL8A1),
Asporin
(ASPN),
Hemoglobin
Subunit
(HBB)
showed
significant
dysregulation
heart
tissues
implicated
multiple
types.
Pan-cancer
analysis
revealed
associations
between
these
prognosis.
Correlations
cancer-associated
fibroblasts
also
observed.
FMOD,
POSTN,
LTBP2,
COL1A1,
COL8A1,
ASPN,
HBB
are
potential
fibrotic
microenvironments.
Targeting
fibrosis
may
offer
novel
approaches.
Further
validation
mechanistic
studies
needed.
This
study
contributes
understanding
at
the
molecular
level
suggests
personalized
treatment
strategies.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
174, С. 116500 - 116500
Опубликована: Март 30, 2024
Chrysin
is
a
natural
flavonoid
with
powerful
neuroprotective
capacity.
Cerebral
ischemia/reperfusion
injury
(CIRI)
associated
oxidative
stress
and
ferroptosis.
Hypoxia-inducible
factor
1α
(HIF-1α)
ceruloplasmin
(CP)
are
the
critical
targets
for
oxidation
reactions
iron
transport.
But
regulatory
mechanism
between
them
still
unclear.
Transient
middle
cerebral
artery
occlusion
(tMCAO)
model
in
rats
oxygen
glucose
deprivation/re-oxygenation
(OGD/R)
PC12
cells
were
applied.
Pathological
tissue
staining
biochemical
kit
used
to
evaluate
effect
of
chrysin.
The
relationship
HIF-1α
CP
was
verified
by
transcriptomics,
qRT-PCR
Western
blot.
In
CIRI,
HIF-1α/CP
loop
discovered
be
pathway
CIRI
led
activation
nuclear
translocation
HIF-1α,
which
promoted
transcription
translation,
downstream
Inhibition
had
opposite
on
ferroptosis
regulation.
Overexpression
increased
expression
nevertheless,
inhibited
alleviated
CIRI.
Silencing
elevation
nucleus
aggravated
Mechanistically,
chrysin
restrained
translocation,
thereby
inhibiting
turn
reduced
mitigated
Our
results
highlight
restrains
through
loop.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
175, С. 116793 - 116793
Опубликована: Май 21, 2024
High-altitude
myocardial
injury
(HAMI)
represents
a
critical
form
of
altitude
illness
for
which
effective
drug
therapies
are
generally
lacking.
Notoginsenoside
R1,
prominent
constituent
derived
from
Panax
notoginseng,
has
demonstrated
various
cardioprotective
properties
in
models
ischemia/reperfusion
injury,
sepsis-induced
cardiomyopathy,
cardiac
fibrosis,
and
injury.
The
potential
utility
notoginsenoside
R1
the
management
HAMI
warrants
prompt
investigation.
Following
successful
construction
model,
series
experimental
analyses
were
conducted
to
assess
effects
at
dosages
50
mg/Kg
100
mg/Kg.
results
indicated
that
exhibited
protective
against
hypoxic
by
reducing
levels
CK,
CK-MB,
LDH,
BNP,
leading
improved
function
decreased
incidence
arrhythmias.
Furthermore,
was
found
enhance
Nrf2
nuclear
translocation,
subsequently
regulating
SLC7A11/GPX4/HO-1
pathway
iron
metabolism
mitigate
ferroptosis,
thereby
mitigating
inflammation
oxidative
stress
induced
high-altitude
conditions.
In
addition,
application
ML385
confirmed
involvement
translocation
therapeutic
approach
HAMI.
Collectively,
advantageous
impacts
on
have
been
linked
suppression
ferroptosis
via
signaling.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
174, С. 116529 - 116529
Опубликована: Апрель 2, 2024
Myocardial
infarction
(MI)
is
the
primary
cause
of
cardiac
mortality.
Esculentoside
A
(EsA),
a
triterpenoid
saponin,
has
anti-inflammatory
and
antioxidant
activities.
However,
its
effect
on
MI
remains
unknown.
In
this
study,
protective
mechanisms
EsA
against
were
investigated.
significantly
alleviated
hypoxia-induced
HL-1
cell
injury,
including
increasing
viability,
inhibiting
reactive
oxygen
species
(ROS)
production,
mitochondrial
membrane
potential
(MMP)
lactate
dehydrogenase
(LDH)
leakage.
mouse
model
by
left
coronary
artery
(LAD)
ligating,
obviously
restored
serum
levels
creatine
kinase
isoenzymes
(CK-MB),
troponin
I
(cTnI),
superoxide
dismutase
(SOD)
malondialdehyde
(MDA).
addition,
cardioprotective
was
further
confirmed
infarct
size,
electrocardiogram
echocardiography.
Mechanistically,
targeted
binding
relationship
between
C-X-C
motif
chemokine
receptor
2
(CXCR2)
predicted
molecular
docking
dynamics,
validated
small
molecule
pull-down
surface
plasmon
resonance
tests.
inhibited
CXCR2
level
both
in
vitro
vivo,
correspondingly
oxidative
stress
suppressing
NOX1
NOX2
relieved
inflammation
through
p65
p-p65.
It
demonstrated
that
could
play
role
targeting
CXCR2.
abolished
combination
with
overexpression
vivo.
This
study
revealed
showed
excellent
activities
to
alleviate
MI.
may
function
as
novel
inhibitor
potent
candidate
for
prevention
intervention
future.
